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| 1 | Reelin induces EphB activation显示文摘进功能的 neuronal 网络的新生的神经原的集成在 neuronal 进程和与另外的神经原的 synaptic 接触的形成的发展中的大脑,生长和树枝状要求房间的移植到他们的最后的位置。在协调区别事件的这个复杂序列的信号之中的一个中央播放器是分泌 glycoprotein Reelin,它也调制 synaptic 粘性,学习并且在成年大脑的记忆形成。到 ApoER2 和 VLDL 受体的 Reelin 有约束力, LDL 受体家庭的二个成员,开始包含细胞内部的细胞质的适配器蛋白质 Disabled-1 的酷氨酸 phosphorylation 的发信号的串联,它指向 neuronal 细胞骨架并且最终控制在整个发展中的大脑放神经原。然而, Reelin 信号与另外的调停受体的发信号串联交往调整大脑开发和粘性的不同方面,是可能的。EphB 酷氨酸 kinases 经由通过 ephrin B transmembrane 蛋白质的双向发信号调整房间粘附和排斥依赖者过程。这里,我们证明 Reelin 绑在 EphB transmembrane 蛋白质的细胞外的领域,导致受体聚类和向前在神经原发信号的 EphB 的激活,独立于“古典”的 Reelin 受体, ApoER2 和 VLDLR。因此,鼠标缺乏 EphB1 和 EphB2 显示 CA3 海马趾的金字塔形的神经原的一个放的缺点,类似于那在 Reelin 缺乏的鼠标,和这房间迁居,缺点取决于 EphB 蛋白质的 kinase 活动。一起,我们的数据为在向前发信号的 Reelin 和 EphB 之间的信号集成提供生物化学、功能的证据。 | Elisabeth Bouche Mario I Romero-Ortega Mark Henkemeyer Timothy Catchpole Jost Leemhuis Michael Frotscher Petra May Joachim Herz Hans H Bock | 2013 | Cell Research2013，23，4： | 5 |
| 2 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 3 | BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model显示文摘 | Herz U Gerhold K GruberC | | 0，，： | 2 |
| 4 | Hydrochlorination of acetylene using a supported gold catalyst: A study of the reaction mechanism显示文摘 | Marco Conte Albert F. Carley Clare Heirene David J. Willock Peter Johnston Andrew A. Herzing Christopher J. Kiely Graham J. Hutchings | 2007 | Journal of Catalysis2007，，2： | 2 |
| 5 | Hydrochlorination of acetylene using supported bimetallic Au-based catalysts显示文摘 | Marco Conte Albert F. Carley Gary Attard Andrew A. Herzing Christopher J. Kiely Graham J. Hutchings | 2008 | Journal of Catalysis2008，，1： | 2 |
| 6 | Electron-Hole Diffusion Lengths Exceeding 1 Micrometer in an Organometal Trihalide Perovskite Absorber显示文摘 | Samuel D. Stranks Giles E. Eperon Giulia Grancini Christopher Menelaou Marcelo J. P. Alcocer Tomas Leijtens Laura M. Herz Annamaria Petrozza Henry J. Snaith | 2013 | Science2013，，6156： | 2 |
| 7 | Prognostic significance of precordial ST segment depression on admission electrocardiogram in patients with inferior wall myocardial infarction显示文摘 | Birnbaum Y Herz I Sclarousky S | 1996 | J Am Coll Cardiol1996，28，2： | 1 |
| 8 | Air emissions from foundries: a current survey of literature, suppliers and foundrymen 显示文摘 | McKinley M D Jefcoat I A Herz W J | 1993 | American Foundry Society Transactions1993，101，： | 1 |
| 9 | New electrocardio-graphic criteria for predicting either the right or left circumflex artery as the culprit coronary artery in inferior wall acute myocardial infarction显示文摘 | Assali AR Adler Y | 1997 | Am J Cardiol1997，80，10： | 1 |
| 10 | Implications of inferior ST-segment depression in anterior acute myocardial infarction: electrocardiographic and angiographic correlation显示文摘 | Bimbaum Y Solodky A Herz I | 1994 | Am Heart J1994，127，： | 1 |
| 11 | TGF - β regulates airway responses via T cell 显示文摘 | Sehramm C Herz U Podlech J | 2003 | J Immunol2003，170，： | 1 |
| 12 | Opioids and opioid receptors mediating antinociception at various levels of the neuraxis 显示文摘 | Herz A Millan MJ | 1990 | Physiol Bohemoslov1990，39，5： | 1 |
| 13 | Atrial natriuretic peptide levels after different types of inferior wall myocardial infarction 显示文摘 | Assali A Gilad I Herz I | 1997 | Clin Cardiol1997，20，8： | 1 |
| 14 | Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats显示文摘 | Blasig J Herz A Einhold k | 1973 | Psychopharmacologia1973，33，： | 1 |
| 15 | Structures and functions of multiligand lipoprotein receptor:Macrophage scavenger receptors and LDL receptor- related protein (LRP)显示文摘 | Krieger M Herz J | 1994 | Annu Rev Biochem1994，63，5： | 1 |
| 16 | Airway exposure to bacterial superantigen (SEB) induces lymphocyte-dependent airway inflammation associated with increased airway responsiveness--a model for non-allergic asthma显示文摘 | Herz U Ruckert R Wollenhaupt K | 1999 | Eur J Immunol1999，29，： | 1 |
| 17 | Environmental exposure to endotoxin and its relation to asthma in school-age children显示文摘 | Braun-Fahrlander C Riedler J Herz U | 2002 | N Engl J Med2002，347，： | 1 |
| 18 | ST segment depression in lateral limb leads in inferior wall acute myocardial infarction,implications regarding the culprit artery and the site of obstruction显示文摘 | Hasdai D Birnbaum Y Herz I | 1995 | Eur Heart J1995，16，11： | 1 |
| 19 | Integration of endocytosis and signal transduction by lipoprotein receptors 显示文摘 | Bock HH Herz J | 2003 | Sci STKE2003，176，： | 1 |
| 20 | Dihydroflavonols and other flavonoids of Eupatorium species 显示文摘 | Herz W Gibaja S Bhat S V | 1972 | Phytochemistry1972，11，11： | 1 |
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