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| 1 | Neutrophil extracellular traps in the intestinal mucosa of Eimeria-infected animals显示文摘Objective:To investigate the presence of neutrophil extracellular traps(NETs) in vivo by analysing intestinal sections from experimentally Eimeria bovis-and naturally Eimeria arloingi-infected animals.Methods:Intestinal samples of Eimeria arloingi-and Eimeria bovis-infected animals were analysed by using immunohistochemical and fluorescence approach by using monoclonal antibodies.Results:Classical NET components were confirmed by co-localization of extracellular DNA being decorated with neutrophil elastase and histones in Eimeria-infected tissue samples.Here,extrusion of NETs was exclusively detected in intestinal polymorphonuclear neutrophils infiltrating Eimeria-infected sites.In vivo NETs were either found in close proximity or in direct contact to different Eimeria stages suggesting a stage-independent process.NETs were also found within the gut lumen driven by polymorphonuclear neutrophils that were contacting released oocysts.Conclusions:We postulate that NETs might play an important role in innate defence reactions in coccidiosis therefore significantly altering the outcome of infection. | Tamara Munoz-Caro Liliana Machado Ribeiro da Silva Zaida Renteria-Solis Anja Taubert Carlos Hermosilla | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，4： | 2 |
| 2 | Primary infection of goats with Eimeria ninakohlyakimovae does not provide protective immunity against high challenge infections显示文摘 | A. Ruiz M.C. Mu?oz J.M. Molina C. Hermosilla F. Rodríguez M. Andrada S. Martín A.Guedes D. Pérez L. Matos A.M. López A. Taubert | 2013 | Small Ruminant Research2013，，1： | 1 |
| 3 | Fluorescent Eimeria bovis sporozoites and meront stages in vitro:a helpful tool to study parasite-host cell interactions显示文摘 | Hermosilla C Stamm I Taubert A | 2008 | Parasitol Res2008，102，4： | 1 |
| 4 | Clustering Panel Data via Perturbed Adaptive Simulated Annealing and Genetic Algorithms显示文摘 | Bonzo D C Hermosilla A Y | 2002 | Advances in Complex Systems2002，，4： | 1 |
| 5 | Experimental and numerical investigation of the thermal effects during hydrogen charging in packed bed storage tank 显示文摘 | MOMEN G HERMOSILLA G MICHAU A | 2009 | International Journal of Heat and Mass Transfer2009，52，56： | 1 |
| 6 | Optimizing the treatment of landfill leachate by conventional Fenton and photo-Fenton processes显示文摘 | Hermosilla D Cortijo M Huang C P | 2009 | Science of the Total Environment2009，，407： | 1 |
| 7 | Eimeria bovis: An update on parasite–host cell interactions显示文摘 | Carlos Hermosilla Antonio Ruiz Anja Taubert | 2012 | International Journal of Medical Microbiology . 2012 (4-5)2012，，4： | 1 |
| 8 | Non-linear Fourth-order image interpolation for subpixel edge detection and localization显示文摘 | Hermosilla T Bermejo E Balaguer A | | 0，，09： | 1 |
| 9 | Clustering panel data via perturbed adaptive simulated annealing and genetic algorithms显示文摘 | Bonzo D C Hermosilla A Y | 2002 | Advances in Complex Sytems2002，，4： | 1 |
| 10 | Definition of a compre- hensive set of texture semivariogram features and their evaluation for object- oriented image classification显示文摘 | Balaguer A Ruiz L A Hermosilla T | 2010 | Computers and Geo- sciences2010，36，2： | 1 |
| 11 | Using semivariogram indices to analyse heterogeneity in spatial patterns in remotely sensed images 显示文摘 | Balaguer B A Ruiz L A Hermosilla T | 2013 | Computers and Geosciences2013，50，： | 1 |
| 12 | Optimization of conventional Fenton and ultraviolet-assisted oxidation processes for the treatment of reverse osmosis retentate from a paper mill显示文摘 | HERMOSILLA D MERAYO N ORDOlqEZ R | 2012 | Waste Manage2012，32，6： | 1 |
| 13 | Non-linear fourth-order image interpolation for subpixel edge detection and localization显示文摘 | HERMOSILLA T BERMEJO E BALAGUER A | 2008 | Image and Vision Computing2008，26，9： | 1 |
| 14 | Formation and regeneration of Phaffia rhodozyma protoplasts 显示文摘 | Hermosilla G Leon R Martinez C | 1995 | Boletin Micrologico1995，10，： | 1 |
| 15 | Use of subcutaneous tocilizumab to prepare intravenous solutions for COVID-19 emergency shortage:Comparative analytical study of physicochemical quality attributes显示文摘COVID-19,a disease caused by the novel coronavirus SARS-Co V-2,has produced a serious emergency for global public health,placing enormous stress on national health systems in many countries.Several studies suggest that cytokine storms(interleukins)may play an important role in severe cases of COVID-19.Neutralizing key inflammatory factors in cytokine release syndrome(CRS)could therefore be of great value in reducing the mortality rate.Tocilizumab(TCZ)in its intravenous(IV)form of administration-Ro Actemra?20 mg/m L(Roche)-is indicated for treatment of severe CRS patients.Preliminary investigations have concluded that inhibition of IL-6 with TCZ appears to be efficacious and safe,with several ongoing clinical trials.This has led to a huge increase in demand for IV TCZ for treating severe COVID-19 patients in hospitals,which has resulted in drug shortages.Here,we present a comparability study assessing the main critical physicochemical attributes of TCZ solutions used for infusion,at 6 mg/m L and 4 mg/m L,prepared from Ro Actemra?20 mg/m L(IV form)and from Ro Actemra?162 mg(0.9 m L solution pre-filled syringe,subcutaneous(SC)form),to evaluate the use of the latter for preparing clinical solutions required for IV administration,so that in a situation of shortage of the IV medicine,the SC form could be used to prepare the solutions for IV delivery of TCZ.It is important to remember that during the current pandemic all the medicines are used off-label,since none of them has yet been approved for the treatment of COVID-19. | Natalia Navas Jesús Hermosilla Anabel Torrente-Lopez Jose Hernandez-Jimenez Jose Cabeza Raquel Perez-Roblesa Antonio Salmeron-García | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 1 |
| 16 | Hydrogen storage by adsorption on activated carbon: investigation of the thermal effects during the charging process 显示文摘 | HERMOSILLA - LARA G MOMEN G MARTY P H | 2007 | International Journal of Hydrogen Energy2007，32，1011： | 1 |
| 17 | Genetics and electrophoretic karyotyping of wild-type and astaxanthin mutant strains of Phaffia rhodozyma显示文摘 | Víctor Cifuentes Germán Hermosilla Claudio Martínez Ruben León Guido Pincheira Antonio Jiménez | 1997 | Antonie van Leeuwenhoek1997，，2： | 1 |
| 18 | The application of advanced oxidation technologies to the treatment of effluents from the pulp and paper industry:a review显示文摘 | Hermosilla D Merayo N Gasco A | 2015 | Environmental Science and Pollution Research January2015，22，1： | 1 |
| 19 | Overexpression of phosphorylated 4E-BP1 predicts for tumor recurrence and reduced survival in cervical carcinoma treated with postoperative radiotherapy显示文摘 | Benavente S Verges R Hermosilla E | 2009 | Int J Radiat Oncol Biol Phys2009，75，5： | 1 |
| 20 | Evaluation of automatic building detec- tion approaches combining high resolution images and LiDAR data显示文摘 | Hermosilla T | 2011 | Remote Sensing2011，3，6： | 1 |
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