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| 1 | Preparation of thalidomide nano-flakes by supercritical antisolvent with enhanced mass transfer显示文摘Thalidomide treats multiple myeloma and protracts life-span of patient, but its bioavailability is limited as it is poorly water soluble. Thalidomide nano-flakes are produced to improve the drug dissolution rate. Two nanoflake production methods are utilized for a comparative study:a supercritical antisolvent (SAS) method and a supercritical antisolvent with enhanced mass transfer (SAS-EM). SAS-EM utilizes ultrasonication to improve dispersion upon injection within the supercritical carbon dioxide. Comparative study of SAS and SAS-EM thalidomide confirmed that the application of ultrasonication improved the micro/nano particles produced by SAS. The effects of ultrasound power on the formation of thalidomide particles are examined. The particle size and morphology were characterized by SEM. The thalidomide nano-flakes produced by SAS-EM were smaller than the particles produced by SAS. Dissolution rates of the produced particles, evaluated by HPLC, demonstrated an increase in the thalidomide dissolution rate for the SAS-EM produced particles. The polymorphs and crystallinity of thalidomide particles (flakes) were observed by FTIR and XRD. In this research, the supercritical processing significantly modified the crystal formation of thalidomide from an original state of a β-polymorph to the amorphous state β-polymorph after supercritical processing. | HeyangJin Melinda Hemingway Ram B. Gupta Fei Xia Yaping Zhao | 2012 | Particuology2012，10，1： | 5 |
| 2 | 公共健康、养生条件与旅游发展:旅游目的地品牌化的机会显示文摘1引言随着世界各地旅游目的地竞争的加剧,不论其地理位置和类型(如城市、农村、海滨),旅游目的地面临的探寻新的变化形式以使其在拥挤的市场中仍然保持脱颖而出的压力一直在增加①。正如摩根(Morgan)、普里查德(Pritchard)和普莱德(Pride)指出的那样,"在一个重信息。 | Alan Fyall Heather Hartwell Ann Hemingway 徐婉倩 | 2013 | 旅游学刊2013，28，2： | 5 |
| 3 | Insecticide Resistance in Insect Vectors of Human Disease显示文摘 | Janet Hemingway Hilary Ranson | 2000 | Annual Review of Entomology2000，，： | 4 |
| 4 | 传病蚊媒对杀虫剂抗性的遗传学显示文摘对杀虫剂抗性遗传学的早期研究表明,单个有显著表型效应的半显性基因与抗性有关。生物化学研究还确定了由这些基因编码的少量酶和神经结构蛋白。近年来,已能通过测定基因型的频率来探索抗性机制。大部分有显著表型效应的抗性基因的分子生物学研究正在进行之中,经扩增的致倦库蚊的酯酶B1基因已得到克隆。作者评述了蚊类杀虫剂抗性遗传学研究的一些新进展。 | Hemingway J 陈伟 | 1993 | 国外医学(寄生虫病分册)1993，20，3： | 3 |
| 5 | 介电测井新技术与应用显示文摘介电测井仪通过地层电磁波测量能分析淡水环境储层,识别可流动油气。介电测井数据资料对分析稠油储层特别有用。一种新型仪器通过长时间的应用,正将新的生机带入介电测井技术。这一切都得益于最近开发的、用于评价碳酸盐岩结构和泥质对砂岩影响的频散技术。 | Romulo Carmona Eric Decoster Jim Hemingway Mehdi Hizem Laurent Mosse Tarek Rizk Dale Julander Jeffrey Little Tom McDonald Jonathan Mude | 2013 | 国外测井技术2013，，5： | 3 |
| 6 | 高分辨率能谱测井——识别复杂矿物(二)显示文摘中子诱发俘获能谱测井仪能够测量井下岩石中特定元素的含量。岩石物理师可根据这些测量数据得出矿物、岩性和地层骨架等性质。早期能谱测井仪的能谱灵敏度不足以获取总有机碳数据,而总有机碳是认识非常规资源远景区的重要测量数据。一种新的测井仪器可提供总碳测量,据此可确定有机碳含量。该仪器在识别复杂岩性方面有着前所未有的精度。 | Manuel Aboud Rob Badry Jim Grau Susan Herron FaridHamichi Jack Horkowitz James Hemingway Robin MacDonald Pablo Saldungaray Don Stachiw Northern Cross Christian Stoller Princeston Junction Richard E.Williams | 2015 | 国外测井技术2015，0，1： | 2 |
| 7 | Managers’ Personal Values as Drivers of Corporate Social Responsibility显示文摘 | Christine A. Hemingway Patrick W. Maclagan | 2004 | Journal of Business Ethics2004，，1： | 2 |
| 8 | Arm position and blood pressure measurement显示文摘 | Guss DA Abdelnur D | 2004 | Annals of Internal Medicine2004，140，： | 1 |
| 9 | Thermal degradation of terpenes:Camphene,Δ3-Carene,Limonene and α-Terpinene显示文摘 | Gerald W Mcgraw Richard W Hemingway Leonard L Ingram JR | | 0，，： | 1 |
| 10 | Circumfeterential mucosectmy(stapled haemorrhoidectomy)versus conventional haemorrhoidectomy:randomized controlledtrial显示文摘 | ROWSELL M BELLO M HEMINGWAY D M | 2000 | Lancet2000，355，9206： | 1 |
| 11 | Specialist investigation of obscure gastrointestinal bleeding显示文摘 | Thompson JN Salem RR Hemingway APo | 1987 | Gut1987，28，： | 1 |
| 12 | Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock显示文摘 | Pathan N Hemingway CA Alizadeh AA | 2004 | Lancet2004，363，9404： | 1 |
| 13 | Prognostic significance of elevated endothelin-1 levels in patients with colorectal cancer显示文摘 | Arun C London NJ Hemingway DM | 2004 | Int J Biol Markers2004，19，1： | 1 |
| 14 | For condensed tanninresourced adducts in laminating adhesives 显示文摘 | KREIBICH R E HEMINGWAY R W | 1985 | Forest Pro J1985，35，3： | 1 |
| 15 | British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children显示文摘 | Thwaites G Fisher M Hemingway C | 2009 | Infect2009，59，： | 1 |
| 16 | Human gene for physical performance 显示文摘 | Montgomery H E Marshall R Hemingway H | 1998 | Nature1998，21，5： | 1 |
| 17 | Human gene for physical performance显示文摘 | Montgomery HE Marshall R Hemingway H | 1998 | Nature1998，393，： | 1 |
| 18 | Endothelin-1 is a novel prognostic factor in non-small cell lung cancer显示文摘 | Arun C De Catris M Hemingway DM | 2004 | Int J Biol Markers2004，19，4： | 1 |
| 19 | PCR-based methods for the detection of L1014 kdr mutation in Anopheles culicifacies sensu lato 显示文摘 | Singh OP Bali P Hemingway J | 2009 | Malar J2009，8，： | 1 |
| 20 | Percutaneous needle biopsy of the lung 显示文摘 | Allison D J Hemingway AP | 1981 | Br Med J Clin Res Ed1981，282，6267： | 1 |
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