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| 1 | 高剂量利福平、莫西沙星和SQ109治疗肺结核:一项多组别、多阶段的随机对照试验显示文摘背景 结核病是世界传染病死亡的第一杀手,目前结核病治疗仍需要至少6个月的疗程,本临床试验旨在研究更短,更安全的敏感性结核病治疗方案. | Boeree MJ Heinrich N Aarnoutse R 申晓娜 孙勤 | 2017 | 中国防痨杂志2017，39，7： | 23 |
| 2 | Immunobiology and immunotherapy of HCC:spotlight on innate and innate-like immune cells显示文摘Immune-based therapies such as immune checkpoint inhibitors have revolutionized the systemic treatment of various cancer types.The therapeutic application of monoclonal antibodies targeting inhibitory pathways such as programmed cell death-1(PD-1)/programmed cell death ligand 1(PD-L1)and CTLA-4 to cells of the adaptive immune system has recently been shown to generate meaningful improvement in the clinical outcome of hepatocellular carcinoma(HCC).Nevertheless,current immunotherapeutic approaches induce durable responses in only a subset of HCC patients.Since immunologic mechanisms such as chronic inflammation due to chronic viral hepatitis or alcoholic and nonalcoholic fatty liver disease play a crucial role in the initiation,development,and progression of HCC,it is important to understand the underlying mechanisms shaping the unique tumor microenvironment of liver cancer.The liver is an immunologic organ with large populations of innate and innate-like immune cells and is exposed to bacterial,viral,and fungal antigens through the gut-liver axis.Here,we summarize and highlight the role of these cells in liver cancer and propose strategies to therapeutically target them.We also discuss current immunotherapeutic strategies in HCC and outline recent advances in our understanding of how the therapeutic potential of these agents might be enhanced. | Benjamin Ruf Bernd Heinrich Tim F.Greten | 2021 | Cellular & Molecular Immunology2021，18，1： | 18 |
| 3 | Long-term follow-up after complete ablation of Barrett's esophagus with argon plasma coagulation显示文摘AIM: To report the long-term outcome of patients after complete ablation of non-neoplastic Barrett's esophagus (BE) with respect to BE relapse and development of intraepithelial neoplasia or esophageal adenocarcinoma.METHODS: In 70 patients with histologically proven nonneoplastic BE, complete BE ablation was achieved by argon plasma coagulation (APC) and high-dose proton pump inhibitor therapy (120 mg omeprazole daily). Sixty-six patients (94.4%) underwent further surveillance endoscopy. At each surveillance endoscopy four-quadrant biopsies were taken from the neo-squamous epithelium at 2 cm intervals depending on the pre-treatment length of BE mucosa beginning at the neo-Z-line, and from any endoscopically suspicious lesion.RESULTS: The median follow-up of 66 patients was 51 mo (range 9-85 mo) giving a total of 280.5 patient years.A mean of 6 biopsies were taken during surveillance endoscopies. In 13 patients (19.7%) tongues or islands suspicious for BE were found during endoscopy. In 8 of these patients (12.1%) non-neoplastic BE relapse was confirmed histologically giving a histological relapse rate of 3% per year. In none of the patients, intraepithelial neoplasia nor an esophageal adenocarcinoma was detected.Logistic regression analysis identified endoscopic detection of islands or tongues as the only positive predictor of BE relapse (P = 0.0004).CONCLUSION: The long-term relapse rate of nonneoplastic BE following complete ablation with high-power APC is low (3% per year). | Ahmed Madisch Stephan Miehike Ekkehard Bayerdoerffer Birgit Wiedemann David Antos Anke Sievert Michael Vieth Manfred Stolte Heinrich Schulz | 2005 | World Journal of Gastroenterology2005，11，8： | 14 |
| 4 | CCD器件空间滤波在微粒运动速度检测上的应用显示文摘本文报道了基于空间滤波法对变加速运动物体表面运动速度进行实时测量的实验研究。采用 CCD线阵同时作为空间滤波器和光电转换器件。由 CCD线阵实现的差分栅式空间滤波器不仅消除了零频分量对低速运动测量的不利影响 ,而且导致了一种快速动态累加采样方法。实验结果表明 ,这一方法可对变加速物体运动速度进行实时测量 。 | 董正超 Klaus Michel Swen Bergeler Klaus Christofori Heinrich Krambeer | 2000 | 仪器仪表学报2000，21，2： | 9 |
| 5 | ON CAUCHY-POMPEIU FORMULA FOR FUNCTIONS WITH VALUES IN A UNIVERSAL CLIFFORD ALGEBRA显示文摘This paper obtains the Cauchy-Pompeiu formula on certain distinguishedboundary for functions with values in a universal Clifford algebra. This formula is just anextension of the Cauchy's integral formula obtained in [11]. | Heinrich Begehr 张忠祥 杜金元 | 2003 | Acta Mathematica Scientia2003，23，1： | 8 |
| 6 | The first dinosaur tracksite from Xinjiang, NW China (Middle Jurassic Sanjianfang Formation, Turpan Basin)──a preliminary report显示文摘A new dinosaur tracksite was discovered in a steeply inclined sandstone layer of the Middle Jurassic Sanjianfang Formation in the Shanshan area of the Turpan Basin. The site is the first record of dinosaur footprints from Xinjiang Province in northwestern China. More than 150 tridactyl theropod dinosaur footprints are preserved as positive hyporeliefs on the lower bedding plane of a fine-grained sandstone body. Most of the footprints are isolated and appear to be randomly distributed. Some show well defined phalangeal pads, heels and rarely indistinct impressions of the distal part of the metatarsus. Two distinct morphotypes are present: a larger type with relatively broad pads shows similarities to Changpeipus and Megalosauripus, and a slightly smaller, slender and gracile type which is similar to Grallator, Eubrontes and Anchisauripus. In both morphotypes, digit III is the longest with a length between 11.4 and 33.6 cm. A single imprint shows prominent scratches, probably formed during slipping of the track maker. | Oliver WINCS Rico SCHELLHORN Heinrich MALLISON Ben THUY Wenhao WU Ge SUN | 2007 | Global Geology2007，10，2： | 8 |
| 7 | 高通量透析膜蛋白质通透性的研究显示文摘目的评估高通量透析膜的蛋白质通透性。方法所有的透析模式均设为单纯超滤,在应用不同的透析膜透析时于透析器的出液口留取滤出液标本,同时进行蛋白质浓度测定和十二烷基硫酸钠-聚丙烯酰氨凝胶电泳(SDS-PAGE)作蛋白质电泳分析。SDS-PAGE采用银染色的方法并根据Melzer的方法作了改良,结果应用激光吸光度测定仪进行条带分析。结果透析膜滤出液中蛋白质条带与经肾小球膜滤出的蛋白质相似,含IgG、转铁蛋白、视黄醇结合蛋白和β2-微球蛋白。由于不同的透析膜的分子截留量、电荷和吸附能力不同,其蛋白质条带的分布亦不同。随着透析的进行,所有膜的通透性都逐渐下降。结论高通量透析膜的蛋白质通透性与肾小球滤过膜相似,但受孔径、表面所带电荷、吸附能力和透析时间的影响而发生改变。与人体的肾小球滤过膜不同,随着透析的进行,透析膜的蛋白质通透性下降。 | 徐筱琪 Siegfried Stiller Helmut Mann 钱家麒 Heinrich Melzer | 2005 | 中华肾脏病杂志2005，21，9： | 6 |
| 8 | 金属标准物质中杂质的辉光放电质谱法溯源分析显示文摘标准物质定值分析的溯源性要求比常规分析高很多。在常规分析中,有证标准物质(CRM)可用于校准以及建立可溯源性。尽管与标准物质生产和认定相关的ISO导则并没有十分明确地提到校准,但众多标准物质生产者在定值分析时却不接受基准标准物质用于校准。这些要求制约了标准物质定值方法的使用,因为这些方法可以采用已知高纯度的标准物质、化学计量法及已知高纯度标准物质的混合物进行校准。有效的固体取样技术,例如通常使用的块状标准物质进行校准的辉光放电质谱法(GD-MS)或火花源发射光谱法(spark-OES),似乎不太适合定值分析。尤其是固体样品中痕量元素分析测定的有力工具辉光放电质谱法,除金属杂质外,使用特定气体混合物,这种方法也可以分析相关的非金属杂质如硫和磷。我们开发了一种可以使用已知高纯度的标准物质混合物和化学计量法的校准方法,这种校准方法同样可用于辉光放电质谱法。与溶液中基体匹配技术类似,此校准方法基于掺杂的粉末压片。本文还结合铜和钢标准物质的定值分析结果进行了陈述。 | RECKNAGEL Sebastian KIPPHARDT Heinrich LANGE Britta HOPPE Marion | 2012 | 冶金分析2012，32，2： | 6 |
| 9 | ^99Tc^m-MIBI心肌灌注显像及^18F-FDG PET心肌代谢显像探测左心室室壁瘤心肌存活性的临床价值显示文摘目的评估^99锝^18-甲氧基异腈(^99Tc^m-MIBI)单光子发射计算机断层(SPECT)心肌灌注显像及^18F-脱氧葡萄糖(FDG)正电子发射断层(PET)心肌代谢显像探测左心室室壁瘤(室壁瘤)心肌存活性的临床价值。方法46例确诊为室壁瘤合并左心功能不全[左心射血分数(LVEF)36%±7%],行^99Tc^m-MIBI SPECT+^18 F-FDGPET显像,并接受血运重建术的患者,随访(80±27)个月。根据室壁瘤是否有存活心肌[灌注一代谢不匹配分(MMS)≥2.0分]以及是否行室壁瘤切除术,将患者分为4个小组:室壁瘤无存活心肌(A组):血运重建术为A1组(n=8),血运重建术+瘤切除术为A2组(n=15);室壁瘤有存活心肌(B组):血运重建术为B1组(n=10),血运重建术+瘤切除术为B2组(n=13)。结果A1、A2、B1、B24个组心脏事件发生率分别为25%(2/8),40%(6/15),20%(2/10)和31%(4/13)(P〉0.05)。除A1组外,其他各组的术后左心功能均得到明显改善(P〈0.05)。多因素logistic回归分析筛选出与术后LVEF改善相关的独立影响因素,为左心室的MMS(OR=2.34,95%CI1.08—5.06,P〈0.05),非室壁瘤部位的心肌灌注分(OR=0.24,95%CI 0.07~0.85,P〈0.05)和远端血管病变(OR=0.008,95%CI 0.001~0.560,P〈0.05)。结论室壁瘤接受血运重建术的患者,长期预后良好。室壁瘤部位有存活心肌的患者,单纯的血运重建术也可以明显改善左心功能,且与心肌存活的量相关。 | 张晓丽 刘秀杰 胡盛寿 Thomas Schindler 田月琴 高润霖 吴清玉 魏红星 杨秀滨 王浩 何作祥 Heinrich R.Schelbert | 2008 | 中华心血管病杂志2008，36，11： | 5 |
| 10 | Influence of liquid layers on energy absorption during particle impact显示文摘The influence of the thickness of a covering liquid layer and its viscosity as well as the impact velocity on energy loss during the normal impact on a flat steel wall of spherical granules with a liquid layer was studied. Free-fall experiments were performed to obtain the restitution coefficient of elastic–plastic Al2O3 granules by impact on the liquid layer, using aqueous solutions of hydroxypropyl methylcellulose with different concentrations for variation of viscosity (1–300 mPa s). In the presence of a liquid layer, increase of liquid viscosity decreases the restitution coefficient and the minimum thickness of the liquid layer at which the granule sticks to the wall. The measured restitution coefficients were compared with experiments performed without liquid layer. In contrast to the dry restitution coefficient, due to viscous losses at lower impact velocity, higher energy dissipation was obtained. A rational explanation for the effects obtained was given by results of numerically solved force and energy balances for a granule impact on a liquid layer on the wall. The model takes into account forces acting on the granule including viscous, surface tension, capillary, contact, drag, buoyancy and gravitational forces. Good agreement between simulations and experiments has been achieved. | Sergiy Antonyuk Stefan Heinrich Niels Deen Hans Kuipers | 2009 | Particuology2009，7，4： | 5 |
| 11 | Gastrointestinal stromal tumour显示文摘 | Rubin BP Heinrich MC Corless CL | | 0，，9574： | 5 |
| 12 | DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination显示文摘 | Weihua Qin Patricia Wolf Nan Liu Stephanie Link Martha Smets Federica La Mastra Ignasi Forne Garwin Pichler David Horl Karin Fellinger Fabio Spada Ian Marc Bonapace Axel Imhof Hartmann Harz Heinrich Leonhardt | 2015 | Cell Research2015，25，8： | 5 |
| 13 | ^18F-FDG PET心肌代谢显像对左心室室壁瘤患者长期预后的价值显示文摘目的评估^18F-脱氧葡萄糖(FDG)PET心肌代谢显像对左心室室壁瘤患者长期预后的价值。方法对70例左心室室壁瘤患者[超声心动图示左心室射血分数(LVEF)为(36±8)%]行“Tc”.甲氧基异丁基异腈(MIBI)SPECT心肌灌注显像和“F—FDG PET—心肌代谢显像,对经冠状动脉造影确诊的左心室室壁瘤患者进行随访,计算室壁瘤部位、非室壁瘤部位以及左心室心肌灌注和代谢积分,以及灌注-代谢不匹配分(MMS)。MMS≥2.0为心肌存活。室壁瘤部位心肌不存活者中,药物治疗为组1,手术治疗为组2;室壁瘤部位心肌存活者中,药物治疗为组3,手术治疗为组4。心源性死亡和心脏事件为随访终点。以Kaplan—Meier方法获得生存曲线,并用Log—rank法比较率的差异。结果组1至组4患者例数分别为14,23,10和23例。随访1~105(72±32)个月,16例患者发生心源性死亡。组3的心源性年死亡率为11.6%,高于组4的1.5%(Х^2=12.87,P〈0.0001),也高于组1的4.8%(Х^2=4.13,P〈0.05)和组2的2.2%(Х^2=10.46,P=0.001)。Cox回归多因素分析显示室壁瘤部位的MMS[风险比(HR)1.40,95%可信区间(CI)为1.11~1.75,P=0.003]和血运重建术(HR 0.35,95%CI为0.18~0.69,P=0.002)是预测心源性死亡的独立危险因子。结论“F—FDG PET心肌代谢显像和^99Tc^m-MIBI SPECT心肌灌注显像对于室壁瘤患者的饴疗方案制定及长期预后估测有重要意义。 | 张晓丽 刘秀杰 胡盛寿 Thomas H.Schindler 田月琴 高润霖 吴清玉 魏红星 杨秀滨 王浩 何作祥 Heinrich R.Schelbert | 2008 | 中华核医学杂志2008，28，6： | 5 |
| 14 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 15 | Coefficient of restitution for particles impacting on wet surfaces: An improved experimental approach显示文摘 | B. Cunger V. Salikov S. Heinrich S. Antonyuk V.S. Sutkar N.G. Deen J.A.M. Kuipers | 2016 | Particuology2016，14，2： | 4 |
| 16 | Product design based on discrete particle modeling of a fluidized bed granulator显示文摘Fluidized bed agglomeration is a process commonly used to construct powdered food or pharmaceutical products to improve their instant properties. This works analyzes the influence of a wide range of operating parameters(i.e., fluidization air flow rate, temperature, and liquid injection rate) on growth rate, process stability, and product particle structure. Different granulator configurations(i.e., top spray,Wurster coater, spouted bed) are compared using identical process parameters. The impacts of both process variables and granulator geometry on the fluidization regime, the particle and collision dynamics, and the resulting product structure and corresponding properties are studied in detailed simulations using a discrete particle model(DPM) and lab-scale agglomeration experiments with amorphous dextrose syrup(DE21). The combination of numerical and experimental results allows to correlate the kinetics of microscale particle interactions and the final product properties(i.e., agglomerate structure and strength). In conclusion, detailed DPM simulations are proven as a valuable tool for knowledge-based product design. | Lennart Fries Sergiy Antonyuk Stefan Heinrich Gerhard Niederreiter Stefan Palzer | 2014 | Particuology2014，12，1： | 4 |
| 17 | Geochemistry of Sinian tillites from Hunan Province, South China——A test of the Snowball Earth hypothesis显示文摘A glaciomarine succession of Neoproterozoic age (between 748~584 Ma) is widespread on the Yangtze Platform, South China. The deposition took place during an intermediate to low paleolatitude position of the Yangtze Platform. The Snowball Earth hypothesis offers an explanation for the occurrence of low-latitude tillites in general. It is based on records obtained of deposits underlying and overlying the tillites. In contrast, we focused on the tillites themselves by using geochemistry to obtain detailed information about the conditions during the glaciation. Of particular interest are environmental conditions, which are closely related to the climate development. Additionally, stable isotope geochemistry was used for a paleoclimate interpretation. The geochemical results of the Sinian glacial succession on the Yangtze Platform are compared to the predictions made by the Snowball Earth hypothesis. | Nicole DOBRZINSKI Heinrich BAHLBURG Harald STRAUSS | 2003 | Progress in Natural Science:Materials International2003，13，11： | 3 |
| 18 | 关于高产母猪饲养管理及饲粮的几个问题显示文摘近些年来,母猪的繁殖性能已经得到很大程度地提高。目前,养殖发达国家的PSY已经超过30头。母猪如此高产,养猪生产者如何保障其泌乳的质和量?饲养管理能否跟上?饲喂策略和饲粮的组成是否相匹配?原文作者对上述问题进行了简单论述。 | Heinrich Kleine Klausing Gelamin Wildeshausen 张振玲(编译) | 2020 | 养猪2020，，2： | 3 |
| 19 | Surfel-based surface modeling for robotic belt grinding simulation显示文摘The new free-form surface modelling technology for robotic belt grinding simulation presented in this paper is based on discrete surfel elements generated from the surface approximation point set and can facilitate the simulation implementation. A local process model exploits the advantage of surfel representation to compute the material removal rate and the final surface grinding error can be easily carried out. With the help of this system, robot programmers can improve the path planning and predict potential problems by visualizing the manufacturing process. | REN Xiang-yang MUELLER Heinrich KUHLENKOETTER Bernd | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，7： | 3 |
| 20 | DICER-like Proteins and Their Role in Plant-herbivore Interactions in Nicotiana attenuata显示文摘DICER-like (DCL) proteins produce small RNAs that silence genes involved in development and defenses against viruses and pathogens. Which DCLs participate in plant-herbivore interactions remains unstudied. We identified and stably silenced four distinct DCL genes by RNAi in Nicotiana attenuata (Torrey ex. Watson), a model for the study of plant-herbivore interactions. Silencing DCL1 expression was lethal. Manduca sexta larvae performed significantly better on ir-dcl3 and ir-dcl4 plants, but not on ir-dcl2 plants compared to wild type plants. Phytohormones, defense metabolites and microarray analyses revealed that when DCL3 and DCL4 were silenced separately, herbivore resistance traits were regulated in distinctly different ways. Crossing of the lines revealed complex interactions in the patterns of regulation. Single ir-dcl4 and double ir-dcl2 ir-dcl3 plants were impaired in JA accumulation, while JA- Ile was increased in ir-dcl3 plants. Ir-dcl3 and ir-dcl4 plants were impaired in nicotine accumulation; silencing DCL2 in combination with either DCL3 or DCL4 restored nicotine levels to those of WT. Trypsin proteinase inhibitor activity and transcripts were only silenced in ir-dcl3 plants. We conclude that DCL2/3/4 interact in a complex manner to regulate anti-herbivore defenses and that these interactions significantly complicate the already challenging task of understanding smRNA function in the regulation of biotic interactions. | Tohir Ahmadovich Bozorov Shree Prakash Pandey Son Truong Dinh Sang-Gyu Kim Maria Heinrich Klaus Gase Ian T. Baldwin | 2012 | Journal of Integrative Plant Biology2012，54，3： | 3 |
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