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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | A probabilistic reasoning-based decision support system for selecting remediation technologies for petroleum-contaminated sites 显示文摘 | HE L CHAN C W HUANG G H ZENG G M | 2006 | Expert Systems with Applications2006，30，4： | 1 |
| 3 | One new control model for beam instabilites显示文摘 | He D H | 1999 | Particle Accelerators1999，28，： | 1 |
| 4 | Binding of puerarin to human serum albumin:a spectroscopic analysis and molecular docking显示文摘 | HE Y WANG Y W TANG L F LIU H CHEN W ZHENG Z L ZOU G L | 2008 | J Fluoresc2008，18，2： | 1 |
| 5 | Factors affecting the filter paper method for total and matric suction measurements显示文摘 | LEONG E C HE L RAHARDJO H | 2002 | Geotechnieal Testing Journal2002，25，3： | 1 |
| 6 | Thermal stability of recorded information at high densities显示文摘 | Charap S H Lu P L He Y J | 1997 | IEEE Trans Magn1997，33，1： | 1 |
| 7 | lntracellular trehalose improves the survival of human red blood cells by freeze-drying显示文摘 | He H Liu B L Hua Z Z et aI | 2007 | Ener- gy Power Eng2007，1，1： | 1 |
| 8 | An investigation of the corrosion behavior of A1203-based ceramic composite coating in dilute HCL solution 显示文摘 | YAN D HE J LI X Z LIU Y ZHANG J X DING H L | 2001 | Surf Coat Technol2001，141，： | 1 |
| 9 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
| 10 | Compliant needle modeling and steerable insertion simulation 显示文摘 | Tang L B Chen Y H He X J | 2008 | Computer-Aided Design and Applications2008，5，1234： | 1 |
| 11 | Characterization,gene cloning,and expression of a novel xylanase XYNB from Streptomyces olivaceoviridis A1显示文摘 | WANG Y R ZHANG H L HE Y Z | 2007 | Aquaculture2007，267，1234： | 1 |
| 12 | A bacterial cell-cell commu-nication signal with cross-kingdom structural analogues 显示文摘 | WANG L H HE Y GAO Y | 2004 | Mo-lecular Microbiology2004，51，： | 1 |
| 13 | 查看详情显示文摘 | Zhang J P Yang H P Han K L Deng W Q He G Z Lou N Q | | 0，，： | 1 |
| 14 | Secure and efficient localization scheme in ultra-wideband sensor networks显示文摘 | He D J Cui L Huang H J | | 0，，04： | 1 |
| 15 | Effects of novolac resin modification on mechanical properties of carbon fiber/epoxy composites 显示文摘 | He H W Li K X Wang J L | 2011 | Polym Compos2011，32，2： | 1 |
| 16 | The relationship between CYP17 -3417/ C polymorphism and acne in Chinese subjects revealed by sequen- cing 显示文摘 | He L Yang Z Yu H | 2006 | Dermatology2006，212，4： | 1 |
| 17 | MicroRNA expression pro- filiIlg in human ovarian cancer: miR-214 induces cell sur- vival and cisplatin resistance by targeting PTEN 显示文摘 | Yang H Kong W He L | 2008 | Canc-er Res2008，68，2： | 1 |
| 18 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 19 | Microstructure and mechanical properties of reactive sputtered nanocrystalline (Ti,AI)N fihns 显示文摘 | HE C L ZHANG J L SONG G H | 2015 | Thin Solid Films2015，584，： | 1 |
| 20 | Discrimination of a- larm pheromone(E)-farnesene by aphid odorant-binding proteins 显示文摘 | Qiao H L Tuccori E He X L | 2009 | Insect Biochem Mol Biol2009，39，56： | 1 |
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