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| 1 | Wind-wave hindcast in the Yellow Sea and the Bohai Sea from the year 1988 to 2002显示文摘We performed long-term wind-wave hindcast in the Yellow Sea and the Bohai Sea from the year 1988 to 2002, and then analyzed the regional wave climate. Comparisons between model results and satellite data are generally consistent on monthly mean significant wave height. Then we discuss the temporal and spatial characteristics of the climatological monthly mean significant wave heights and mean wave periods. The climatologically spatial patterns are observed as increasing from northwest to southeast and from offshore to deep-water area for both significant wave height and mean wave period, and the patterns are highly related to the wind forcing and local topography. Seasonal variations of wave parameters are also significant. Furthermore, we compute the extreme values of wind and significant wave height using statistical methods. Results reveal the spatial patterns of N-year return significant wave height in the Yellow Sea and the Bohai Sea, and we discuss the relationship between extreme values of significant wave height and wind forcing. | HE Hailun XU Yao | 2016 | Acta Oceanologica Sinica2016，35，3： | 11 |
| 2 | Interpreting the sea surface temperature warming trend in the Yellow Sea and East China Sea显示文摘Previous studies have demonstrated that the low-frequency sea surface temperature(SST) variability in the Yellow Sea and East China Sea(YECS) is linked to large-scale climate variability, but explanations on the mechanisms vary. This study examines the low-frequency variability and trends of some atmospheric and oceanic variables to discuss their different effects on the YECS warming. The increasing temperature trend is also observed at a hydrographic section transecting the Kuroshio.The increasing rate of ocean temperature decreases with depth, which might result in an increase in vertical stratification and a decrease in vertical mixing, and thus plays a positive role on the YECS warming. The surface net heat flux(downward positive)displays a decreasing trend, which is possibly a result of the YECS warming, and, in turn, inhibits it. Wind speeds show different trends in different datasets, such that its role in the YECS warming is uncertain. The trends in wind stress divergence and curl have large uncertainties, so their effects on SST warming are still unclear. The Kuroshio heat transport calculated in this study,displays no significantly increasing trend, so is an unlikely explanation for the SST warming. Limited by sparse ocean observations,sophisticated assimilative climate models are still needed to unravel the mechanisms behind the YECS warming. | PEI YuHua LIU XiaoHui HE HaiLun | 2017 | Science China Earth Sciences2017，60，8： | 10 |
| 3 | DELLA and EDS1 Form a Feedback Regulatory Module to Fine-Tune Plant Growth-Defense Tradeoff in Arabidopsis显示文摘Plants maintain a dynamic balance between growth and defense,and optimize allocation of resources for survival under constant pathogen infections.However,the underlying molecular regulatory mechanisms,especially in response to biotrophic bacterial infection,remain elusive.Here,we demonstrate that DELLA proteins and EDS1,an essential resistance regulator,form a central module modulating plant growth-defense tradeoffs via direct interaction.When infected by Pst DC3000,EDS1 rapidly promotes salicylic acid(SA)biosynthesis and resistance-related gene expression to prime defense response,while pathogen infection stabilizes DELLA proteins RGA and RGL3 to restrict growth in a partially EDS1-dependent manner,which facilitates plants to develop resistance to pathogens.However,the increasingly accumulated DELLAs interact with EDS1 to suppress SA overproduction and excessive resistance response.Taken together,our findings reveal a DELLA-EDS1-mediated feedback regulatory loop by which plants maintain the subtle balance between growth and defense to avoid excessive growth or defense in response to constant biotrophic pathogen attack. | Yuge Li Yuhua Yang Yilong Hu Hailun Liu Ming He Ziyin Yang Fanjiang Kong Xu Liu Xingliang Hou | 2019 | Molecular Plant2019，12，11： | 8 |
| 4 | Variation of the Kuroshio intrusion pathways northeast of Taiwan using the Lagrangian method显示文摘The seasonal variations of the Kuroshio intrusion pathways northeast of Taiwan were investigated using observational data from satellite-tracked sea surface drifters and a numerical particle-tracking experiment based on a high-resolution numerical ocean model. The results of sea surface drifter data observed from 1989 to 2013 indicate that the Kuroshio surface intrusion follows two distinct pathways: one is a northwestward intrusion along the northern coast of Taiwan Island, and the other is a direct intrusion near the turn of the shelf break. The former occurs primarily in the winter, while the latter exists year round. A particle-tracking experiment in the high-resolution numerical model reproduces the two observed intrusion paths by the sea surface drifters. The three-dimensional structure of the Kuroshio intrusion is revealed by the model results. The pathways, features and possible dynamic mechanisms of the subsurface intrusion are also discussed. | LIU XiaoHui CHEN DaKe DONG ChangMing HE HaiLun | 2016 | Science China Earth Sciences2016，59，2： | 7 |
| 5 | Climate and extrema of ocean waves in the East China Sea显示文摘Wave climate plays an important role in the air-sea interaction over marginal seas. Extreme wave height provides fundamental information for various ocean engineering practices, such as hazard mitigation, coastal structure design, and risk assessment. In this paper, we implement a third generation wave model and conduct a high-resolution wave hindcast over the East China Sea to reconstruct a 15-year wave field from 1988 to 2002 for derivation of monthly mean wave parameters and analysis of extreme wave conditions. The numerical results of the wave field are validated through comparison with satellite altimetry measurements, low-resolution reanalysis, and the ocean wave buoy record. The monthly averaged wave height and wave period show seasonal variation and refined spatial patterns of surface waves in the East China Sea. The climatological significant wave height and mean wave period decrease from the open ocean in the southeast toward the continental area in the northwest, with the pattern generally following the bathymetry. Extreme analysis on the significant wave height at the buoy station indicates the hindcast data underestimate the extreme values relative to the observations. The spatial pattern of extreme wave height shows single peak emerges at the southwest of Ryukyu Island although a wind forcing with multi-core structure at the extreme is applied. | Hailun HE Jinbao SONG Yefei BAI Yao XU Juanjuan WANG Fan BI | 2018 | Science China Earth Sciences2018，61，7： | 7 |
| 6 | Effects of surface waves and sea spray on air–sea fluxes during the passage of Typhoon Hagupit显示文摘Air–sea exchange plays a vital role in the development and maintenance of tropical cyclones(TCs). Although studies have suggested the dependence of air–sea fluxes on surface waves and sea spray, how these processes modify those fluxes under TC conditions have not been sufficiently investigated based on in-situ observations.Using continuous meteorological and surface wave data from a moored buoy in the northern South China Sea,this study examines the effects of surface waves and sea spray on air–sea fluxes during the passage of Typhoon Hagupit. The mooring was within about 40 km of the center of Hagupit. Surface waves could increase momentum flux to the ocean by about 15%, and sea spray enhanced both sensible and latent heat fluxes to the atmosphere,causing Hagupit to absorb 500 W/m^2 more heat flux from the ocean. These results have powerful implications for understanding TC–ocean interaction and improving TC intensity forecasting. | HE Hailun WU Qiaoyan CHEN Dake SUN Jia LIANG Chujin JIN Weifang XU Yao | 2018 | Acta Oceanologica Sinica2018，37，5： | 5 |
| 7 | The normal cell proliferation and wound healing effect of polysaccharides from Ganoderma amboinense显示文摘To study the cell proliferation and wound healing activity of polysaccharides from Ganoderma amboinense(GAMPS),the polysaccharide was extracted by water extraction and alcohol precipitation method,and its monosaccharide composition and molecular weight were analyzed.The effects of different concentrations of GAMPS on the cell proliferation were determined by cell survival rate test,and the wound healing ability of GAMPS to NIH/3T3 cells was detected.The preliminary evaluation of the antioxidant ability of GAMPS was conducted by the oxygen radical absorbance capacity(ORAC).The results showed that the GAMPS was composed of glucose,mannose,and galactose at a molar ratio of 67.62:14.07:7.50,and the weightaverage molecular weights were 5.439×10^(6) and 1.704×10^(5) g/mol by using high-performance gel-permeation chromatography-multiple angle laser scatter(HPGPC-MALS)analysis.GAMPS(0.2μg/μL)showed the strongest proliferation ability to THP-1 cells,with cell survival rate of 178.7%.The wound healing effect of GAMPS(0.1μg/μL)was obvious on NIH/3T3 and 3.75μg/μL of GAMPS showed the strongest total antioxidant ability.All the results indicate that GAMPS promotes cell proliferation,and has cell wound healing effect and strong antioxidant activity.The results provide theoretical foundation for the development and utilization of GAMPS. | Shuangzhi Zhao Ming Lei Hui Xu Hailun He Alexander Suvorov Junhua Wang Jiying Qiu Qingxin Zhou Jinyu Yang Leilei Chen | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 8 | The temporal and spatial variations in the Pacific wind and wave fields for the period 2002–2011显示文摘The temporal and spatial variations in the wind and wave fields in the Pacific Ocean between 2002 and 2011 are analyzed using a third-generation wave model(WAVEWATCH III). The model performance for a significant wave height is validated using in situ buoy data. The results show that the wave model effectively hindcasts the significant wave height in the Pacific Ocean, but the errors are relatively large in the mid- and low-latitude regions. The spatial distributions and temporal variations in a wind speed and the significant wave height in the Pacific Ocean are then considered after dividing the Pacific Ocean into five regions, which show meridional differences and seasonal cycles. Regional mean values are used to give yearly average time series for each separate zone. The high latitude region in the Southern Hemisphere had a stronger significant wave height trend in the model results than regions at other latitudes. The sources and sinks of wave energy are then investigated. Their regional mean values are used to quantify variations in surface waves. Finally, the spectral analyses of the daily mean wind speeds and the significant wave heights are obtained. The significant wave height and the wind speed spectra are found to be connected in some ways but also show certain differences. | XU Yao BI Fan SONG Jinbao HE Hailun | 2017 | Acta Oceanologica Sinica2017，36，3： | 3 |
| 9 | Large eddy simulation of turbulence in ocean surface boundary layer at Zhangzi Island offshore显示文摘这研究使用调查骚乱的模型在 Zhangzi 在海洋表面边界层处理的大旋涡模拟(LES ) 岛近海。在 Zhangzi 岛的领域大小(39 ?? 桴?? | LI Shuang SONG Jinba HE Hailun HUANG Yansong | 2013 | Acta Oceanologica Sinica2013，32，7： | 2 |
| 10 | Molecular analysis of the gene encoding a cold-adapted halophilic subtilase from deep-sea psychrotolerant bacterium Pseudoalteromonas sp. SM9913: cloning, expression, characterization and function analysis of the C-terminal PPC domains显示文摘 | Bing-Qiang Yan Xiu-Lan Chen Xiao-Yan Hou Hailun He Bai-Cheng Zhou Yu-Zhong Zhang | 2009 | Extremophiles2009，，4： | 1 |
| 11 | High throughput and rapid screening of marine protein hydrolysates enriched in peptides with art- giotensin-I-converting enzyme inhibitory activity by capillary electrophoresis显示文摘 | HE Hailun CHEN Xiulan WU Hao | 2007 | Bioresource Technology2007，98，： | 1 |
| 12 | Taste improvement of refrigerated meat treated with cold- adapted protease 显示文摘 | He Hailun Chen Xiulan Li Jianwei | 2004 | Food Chemistry2004，84，2： | 1 |
| 13 | High throughput andrapid screening of marine protein hydrolysates enriched in peptideswith angiotensin-I-converting enzyme inhibitory activity by capillaryelectrophoresis显示文摘 | HE Hailun CHEN Xiulan WU Hao | 2007 | Bioresour Technol2007，98，18： | 1 |
| 14 | High throughput and rapid screening of marine protein hydrolysates enriched in peptides with angiotension- Ⅰ -conveting enzyme inhibitory activity by caprillary electrophoresis显示文摘 | HE Hailun CHEN Xiulan WU Hao | 2007 | Bioresour Teehnol2007，98，18： | 1 |
| 15 | Gene cloning and sequence analysis of the cold-adapted chaperones DnaK and DnaJ from deep-sea psychrotrophic bacterium Pseudoalteromonas sp. SM9913显示文摘Pseudoalteromonas sp.SM9913 is a phychrotrophic bacterium isolated from the deep-sea sediment.The genes encoding chaperones DnaJ and DnaK of P.sp.SM9913 were cloned by normal PCR and TAIL-PCR(GenBank accession Nos DQ640312,DQ504163).The chaperones DnaJ and DnaK from the strain SM9913 contain such conserved domains as those of many other bacteria,and show some cold-adapted characteristics in their structures when compared with those from psychro-,meso-and themophilic bacteria.It is indicated that chaperones DnaJ and DnaK of P.sp.SM9913 may be adapted to low temperature in deep-sea and function well in assisting folding,assembling and translocation of proteins at low temperature.This research lays a foundation for the further study on the cold-adapted mechanism of chaperones DnaJ and DnaK of cold-adapted microorganisms. | ZHAO Dianli CHEN Xiulan HE Hailun SHI Mei ZHANG Yuzhong | 2007 | Acta Oceanologica Sinica2007，26，6： | 1 |
| 16 | Purification and identification of novel angiotensin-1-converting enzyme inhibitory peptides from shark meat hydrolysate显示文摘 | Wu Hao He Hailun Chen Xiulan | 2008 | Process Biochemistry2008，43，4： | 1 |
| 17 | Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate显示文摘 | Wu Hao He Hailun Chen Xiulan | 2007 | Process Biochemistry2007，42，12： | 1 |
| 18 | High throughput and rapid screening of marine protein hydrolysates enriched in peptides with angiotensin-I-converting enzyme inhibitory activity by capillary electrophoresis显示文摘 | He Hailun Chen Xiulan Wu Hao | 2007 | Bioresource Technology2007，98，18： | 1 |
| 19 | Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors显示文摘Substantial progress in the use of chemo-photodynamic nano-drug delivery systems(nanoDDS) for the treatment of the malignant breast cancer has been achieved. The inability to customize precise nanostructures, however, has limited the therapeutic efficacy of the prepared nano-DDS to date. Here,we report a structurally defined tandem-responsive chemo-photosensitive co-nanoassembly to eliminate primary breast tumor and prevent lung metastasis. This both-in-one co-nanoassembly is prepared by assembling a biocompatible photosensitive derivative(pheophorbide-diphenylalanine peptide, PPADA) with a hypoxia-activated camptothecin(CPT) prodrug [(4-nitrophenyl) formate camptothecin, NCPT]. According to computational simulations, the co-assembly nanostructure is not the classical core-shell type, but consists of many small microphase regions. Upon exposure to a 660 nm laser,PPA-DA induce high levels of ROS production to effectively achieve the apoptosis of normoxic cancer cells. Subsequently, the hypoxia-activated N-CPT and CPT spatially penetrate deep into the hypoxic region of the tumor and suppress hypoxia-induced tumor metastasis. Benefiting from the rational design of the chemo-photodynamic both-in-one nano-DDS, these nanomedicines exhibit a promising potential in the inhibition of difficult-to-treat breast tumor metastasis in patients with breast cancer. | Mengchi Sun Hailun Jiang Tian Liu Xiao Tan Qikun Jiang Bingjun Sun Yulong Zheng Gang Wang Yang Wang Maosheng Cheng Zhonggui He Jin Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 20 | GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis显示文摘Recently, Yu et al. [1] revealed that G protein-coupled receptor 146 (GPR146) exerts a detrimental effect on the regulation of systemic cholesterol metabolism. Mechanically, GPR146 induces hepatic sterol regulatory element binding protein 2 (SREBP2) via the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, consequently resulting in hepatic low-density lipoprotein (VLDL) secretion. Notably, GPR146 depletion reduces VLDL secretion and decreases aortic atherosclerotic lesions in low-density lipoprotein receptor (LDLR)-deficient mice via the suppression of ERK1/2/SREBP2 pathway, suggesting that GPR146 may contribute to the incidence of atherosclerosis (AS) and familial hypercholesterolemia (HoFH). Taken together, inhibition of GPR146 is likely to be an effective strategy for AS and HoFH treatment for modulating cholesterol levels. | Lan She Hailun Yao Lingzhi He Yajun Li Jianping Cao | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 1 |
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