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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | ^(40)Ar/^(39)Ar chronology and geochemistry of high-K volcanic rocks in the Mangkang basin, Tibet显示文摘Our two newly obtained high-quality 40Ar/39Ar ages suggest that the high-K volcanic rocks of the Lawuxiang Formation in the Mangkang basin, Tibet were formed at 33.5 ( 0.2 Ma. The tracing of elemental and Pb-Sr-Nd isotopic geochemistry indicates that they were derived from an EM2 enriched mantle in continental subduction caused by transpression. Their evidently negative anomalies in HFSEs such as Nb and Ta make clear that there is an input of continental material into the mantle source. The high-K rocks at 33.5 ( 0.2 Ma in the Mangkang basin may temporally, spatially and compositionally compare with the early one of two-pulse high-K rocks in eastern Tibet distinguished by Wang J. H. Et al., implying that they were formed in the same tectonic setting. | ZHANG Huihua, HE Huaiyu, WANG Jianghai & XIE Guanghong Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China College of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China | 2005 | Science China Earth Sciences2005，48，1： | 13 |
| 3 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 4 | Novel thermal barrier coatings based on La 2 (Zr 0.7 Ce 0.3 ) 2 O 7 /8YSZ double-ceramic-layer systems deposited by electron beam physical vapor deposition显示文摘 | Zhenhua Xu Shimei He Limin He Rende Mu Guanghong Huang Xueqiang Cao | 2011 | Journal of Alloys and Compounds2011，，11： | 1 |
| 5 | Novel thermal barrier coatings based on La 2 (Zr 0.7 Ce 0.3 ) 2 O 7 /8YSZ double-ceramic-layer systems deposited by electron beam physical vapor deposition显示文摘 | Zhenhua Xu Shimei He Limin He Rende Mu Guanghong Huang Xueqiang Cao | 2011 | Journal of Alloys and Compounds2011，，11： | 1 |
| 6 | Plasma electroplating Ni coating on pure copper sheet—the effects of H 2 SO 4 concentration on the microstructure and mechanical properties显示文摘 | Guanghong Zhao Yedong He | 2012 | Surface & Coatings Technology2012，，21： | 1 |
| 7 | Novel thermal barrier coatings based on La 2 (Zr 0.7 Ce 0.3 ) 2 O 7 /8YSZ double-ceramic-layer systems deposited by electron beam physical vapor deposition显示文摘 | Zhenhua Xu Shimei He Limin He Rende Mu Guanghong Huang Xueqiang Cao | 2011 | Journal of Alloys and Compounds2011，，11： | 1 |
| 8 | The Combination of Quantitative PCR and Western Blot Detecting CP4‐EPSPS Component in Roundup Ready Soy Plant Tissues and Commercial Soy‐Related Foodstuffs显示文摘 | Xiao Xiao Honghong Wu Xinghu Zhou Sheng Xu Jian He Wenbiao Shen Guanghong Zhou Ming Huang | 2012 | Journal of Food Science2012，，6： | 1 |
| 9 | A novel therapeutic vaccine based on graphene oxide nanocomposite for tumor immunotherapy显示文摘With an intensive understanding of the mechanism of immune system,developing a therapeutic tumor vaccine is one of the most perspective strategy of cancer immunotherapy.In this study,we report a facile approach to prepare graphene oxide(GO)-based therapeutic cancer-nanovaccine.The model antigen(ovalbumin,OVA)and adjuvant(CpG ODN),are conjugated with GO-PEI nanosheet through electrostatic interaction.The addition of PEG can improve biocompatibility and prevent nanoparticle aggregation.The prepared GO-based nanovaccine,GO-PEI-OVA-PEG-CpG,exhibits good biocompatibility and low toxicity both in vivo and in vitro.More importantly,it can efficiently induce the maturation of dendritic cells(DCs),the enhancement of antigen cross-presentation ability,and the amplification of cytokine production of immune cells.Impressively,this nanovaccine shows a remarkable therapeutic effect against preestablished B16-OVA-melanoma tumors,which can significantly inhibit tumor growth and prolong the survival time of the OVA-expressed tumor-bearing mice.Moreover,combining GO-PEI-OVA-PEG-CpG with NLG919,an IDO-1(indoleamine-2,3-dioxygenase)inhibitor which can regulate the tumor microenvironment,displays a synergistic therapeutic effect.These findings indicate the GO-PEI-OVA-PEG-CpG nanovaccine actively induces an antigen-specific antitumor immune response and it combined with NLG919 could achieve better therapeutic outcomes. | Liming Zhang Lingfeng Xu Yi Wang Jieyu Liu Guanghong Tan Fengying Huang Nongyue He Zhuoxuan Lu | 2022 | Chinese Chemical Letters2022，33，8： | 1 |
| 10 | Charactering the spoilage mechanism of'three sticks'of Jinhua ham显示文摘To investigate the spoilage characteristics of Jinhua ham,sensory scores,volatile compounds,biogenic amine,physicochemical parameters and microbial counts were evaluated between normal and spoiled hams.The results showed that off-odors of spoiled hams were dominated by rancid,sour,sulfide and ammonia odors derived from these compounds including butanoic acid,methanethiol and dimethyl disulfide.Total content of biogenic amine in spoiled hams was significantly higher(more than 10-fold)compared with normal hams,and putrescine,cadaverine and histamine were the key components of biogenic amine of spoiled hams.Lower salt content,and higher moisture,TVB-N and thiobarbituric acid reactive substances(TBARS)values were observed in spoiled hams compared with normal hams.The populations of Enterobacteriaceae and Enterococcus of spoiled hams were obviously higher than that of normal hams.High moisture and low salt content caused the abnormal growth of Enterobacteriaceae and Enterococcus in spoiled hams,which contributed to the spoilage of Jinhua ham. | Changyu Zhou Guang Zhan Daodong Pan Guanghong Zhou Ying Wang Jun He Jinxuan Cao | 2022 | Food Science and Human Wellness2022，11，5： | 1 |
| 11 | Substrate Effects on the High-Temperature Oxidation Behavior of Thermal Barrier Coatings显示文摘The high-temperature oxidation behaviors of the NiCrAlYSi/P-YSZ thermal barrier coatings (TBCs) produced by electron beam-physical vapor deposition (EB-PVD) on directionally solidified (DS) and single crystalline (SC) Ni-based superalloy substrates were investigated. The cross-sectional microstructure investigation, isothermal and cyclic oxidation tests were conducted for the comparison of oxidation behaviors of TBCs on different substrates. Although TBC on DS substrate has a relatively higher oxidation rate, it has a longer thermal cycling lifetime than that on SC substrate. The primary factor for TBC spallation is the mismatch of thermal expansion coefficient (TEC) of the bond coat and substrate. The morphological feature of thermally grown oxide (TGO) has a strong influence on the TBC performance. By optimizing the elemental interdiffusion between bond coat and substrate, a high quality TGO layer is formed on the DS substrate, and therefore the TBC oxidation behavior is improved. | Limin He Zhenhua Xu Jianping Li Rende Mu Shimei He Guanghong Huang | 2009 | Journal of Materials Science & Technology2009，25，6： | 1 |
| 12 | Study and fabrication of a Au/n-ZnO/p-Si structure UV-enhanced phototransistor显示文摘 | Xie Jiachun Li Duan He Guanghong | 2006 | Chinese J of Semiconductors2006，27，1： | 1 |
| 13 | Perspectives on water science: transport and application of confined water显示文摘The confinements of water can be divided into two main categories,namely,the confinements on surface or interface and the confinements in bulk water.By adding ions or applying electric field,the intensity and distribution of the hydrogen bonds can be greatly affected.These are collectively known as confinement on water surface or interface,which has potential applications in life science and industries involving evaporation control.Confined bulk water could be found everywhere in nature,such as in granular and porous materials,macromolecules and gels,etc.The investigation of the physical properties and the transports of the confined bulk water will contribute to understanding certain types of life activities such as the water transport in plant and in new application of extracting the shale oil and water. | ZENG XiPing WU JinBo LI ShunBo CHAU YeungYeung HE GuangHong WEN WeiJia YANG GuoZhen | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，5： | 0 |
| 14 | How to Improve the Survival Rate of Milk Calves显示文摘As a reserve force for a pasture,calf determines the future of the ranch and the future profi t of the ranch.The calf's scientifi c rearing is the most important part of sustainable development of a ranch.Calf management is a complex and detailed work,breeders need to consider three factors:nutrition,disease,and environment.In order to make calves become a good reserve cattle,it is important to ensure that calves have a balanced,adequate nutrition,reduce calving morbidity,mortality,and a suitable environment.More excellent young cattle can produce more prolific lactation cattle.This article introduce the calf feeding and management work from the feeding and management,environmental management and other aspects. | Qishun Huang Guanghong Fang Chunsheng He | 2018 | Insight-Veterinary Science2018，1，1： | 0 |
| 15 | Response and Assessment of the Effectiveness of the Countermeasures for a COVID-19 Outbreak—Guizhou Province,China,March 2022显示文摘Summary What is already known about this topic?Many regions in China have recently reported outbreaks of the coronavirus disease 2019(COVID-19)caused by the Omicron variant.What is added by this report?Wuchuan County,Guizhou Province reacted quickly and implemented accurate intervention measures to effectively control the outbreak.The susceptibleexposed-infectious-asymptomatic-removed(SEIAR)model was applied to evaluate the effectiveness of intervention measures.What are the implications for public health practice?Fast response measures should be taken to prevent the spread of outbreaks caused by the Omicron variant. | Jiao Huang Liying Wang Chun Yu Zhaobing Liu Guanghong Yang Ziyao Lan Zhongfa Tao Kaike Ping He Huang Shijun Li Yan Huang | 2022 | China CDC weekly2022，4，30： | 0 |
| 16 | A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment显示文摘The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 %(37 °C, 5 min) to 0(49 °C, 10 min) with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy(P \ 0.05). Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45–49 °C for5 min within 8 h of infection, worm reduction rate(WRR)reached 74 %–83 %(P \ 0.01). The sensitivity of adultschistosoma to heat was also investigated using microwave intraperitoneal hyperthermia(thermal dosages 42–43 °C,20 min). The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel(PZQ)-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus,hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage. | Huixia Yang Tao Tang Pei He Youren Zhang Le Xie Guangqi Liu Li Li Weichao Kong Jingdingsha Li Ruiting Liu Yukun Li Junjian Hu Xiaowen Wang Liya Li Guanghong Xiang Geoffrey Gobert Yuesheng Li Jintian Tang | 2015 | Science Bulletin2015，60，16： | 0 |
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