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| 1 | Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis显示文摘Obeticholic acid(OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to reduce the incidence of the side-effect of pruritus. Here we propose a combinatory therapeutic strategy of OCA and apoptosis inhibitor for combating against liver fibrosis. CCl4-injured mice, D-galactosamine/LPS(GalN/LPS)-treated mice and cycloheximide/TNFα(CHX/TNFα)-treated HepG2 cells were employed to assess the effects of OCA, or together with IDN-6556, an apoptosis inhibitor. OCA treatment significantly inhibited hepatic stellate cell(HSC)activation/proliferation and prevented fibrosis. Elevated bile acid(BA) levels and hepatocyte apoptosis triggered the activation and proliferation of HSCs. OCA treatment reduced BA levels but could not inhibit hepatocellular apoptosis. An enhanced anti-fibrotic effect was observed when OCA was co-administrated with IDN-6556. Our study demonstrated that OCA inhibits HSCs activation/proliferation partially by regulating BA homeostasis and thereby inhibiting activation of HSCs. The findings in this study suggest that combined use of apoptosis inhibitor and OCA at lower dosage represents a novel therapeutic strategy for liver fibrosis. | Jiyu Zhou Ningning Huang Yitong Guo Shuang Cui Chaoliang Ge Qingxian He Xiaojie Pan Guangji Wang Hong Wang Haiping Hao | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 13 |
| 2 | A fast and versatile cross-linking strategy via o-phthalaldehyde condensation for mechanically strengthened and functional hydrogels显示文摘Fast and catalyst-free cross-linking strategy is of great significance for construction of covalently cross-linked hydrogels.Here,we report the condensation reaction between o-phthalaldehyde(OPA)and N-nucleophiles(primary amine,hydrazide and aminooxy)for hydrogel formation for the first time.When four-arm poly(ethylene glycol)(4 a PEG)capped with OPA was mixed with various N-nucleophile-terminated 4 aPEG as building blocks,hydrogels were formed with superfast gelation rate,higher mechanical strength and markedly lower critical gelation concentrations,compared to benzaldehyde-based counterparts.Small molecule model reactions indicate the key to these cross-links is the fast formation of heterocycle phthalimidine product or isoindole(bis)hemiaminal intermediates,depending on the N-nucleophiles.The second-order rate constant for the formation of phthalimidine linkage(4.3 M-1s-1)is over 3000 times and 200 times higher than those for acylhydrazone and oxime formation from benzaldehyde,respectively,and comparable to many cycloaddition click reactions.Based on the versatile OPA chemistry,various hydrogels can be readily prepared from naturally derived polysaccharides,proteins or synthetic polymers without complicated chemical modification.Moreover,biofunctionality is facilely imparted to the hydrogels by introducing amine-bearing peptides via the reaction between OPA and amino group. | Zhen Zhang Chaoliang He Yan Rong Hui Ren Tianran Wang Zheng Zou Xuesi Chen | 2021 | National Science Review2021，8，4： | 4 |
| 3 | Bioactive polypeptide hydrogels modified with RGD and N-cadherin mimetic peptide promote chondrogenic differentiation of bone marrow mesenchymal stem cells显示文摘Cell-material and cell-cell interactions represent two crucial aspects of the regulation of cell behavior.In the present study,poly(L-glutamic acid)(PLG)hydrogels were prepared by catalyst-free click crosslinking via a strain-promoted azide-alkyne cycloaddition(SPAAC)reaction between azido-grafted PLG(PLG-N3)and azadibenzocyclooctyne-grafted PLG(PLG-ADIBO).The bioactive peptides c(RGDfK)and N-cadherin mimetic peptide(N-Cad)were both conjugated to the PLG hydrogel(denoted PLG+RGD/N-Cad)in order to regulate cell-material and cell-cell interactions.Gelation time and storage modulus of the hydrogels were tunable through variations in the concentration of polypeptide precursors.The hydrogels degraded gradually in the presence of proteinases.The viability of bone marrow mesenchymal stem cells(BMSCs)was maintained when cultured with extracts of the hydrogels or encapsulated within the hydrogels.Degradation was observed within 10 weeks following the subcutaneous injection of hydrogel solution in rats,displaying excellent histocompatibility in vivo.The introduction of RGD into the PLG hydrogel promoted the adhesion of BMSCs onto the hydrogels.Moreover,when encapsulated within the PLG+RGD/NCad hydrogel,BMSCs secreted cartilage-specific matrix,in addition to chondrogenic gene and protein expression being significantly enhanced in comparison with BMSCs encapsulated in hydrogels without N-Cad modification.These findings suggest that these biodegradable,bioactive polypeptide hydrogels have great potential for use in 3D cell culture and in cartilage tissue engineering. | Yan Rong Zhen Zhang Chaoliang He Xuesi Chen | 2020 | Science China Chemistry2020，63，8： | 4 |
| 4 | DOX/IL-2/IFN-g co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment显示文摘Melanoma has been a serious threat to the human health;however,effective therapeutic methods of this cancer are still limited.Combined local therapy is a crucial approach for achieving a superior anti-tumor efficacy.In this paper,a chemo-immunotherapy system of DOX,IL-2 and IFN-g based on poly(g-ethyl-Lglutamate)-poly(ethylene glycol)-poly(g-ethyl-L-glutamate)(PELG-PEG-PELG)hydrogel was developed for local treatment of melanoma xenograft.The drug release process of this system exhibited a short term of burst release(the first 3 days),followed by a long-term sustained release(the following 26 days).The hydrogel degraded completely within 3 weeks without obvious inflammatory responses in the subcutaneous layer of rats,showing a good biodegradability and biocompatibility.The DOX/IL-2/IFN-g co-loaded hydrogel also showed enhanced anti-tumor effect against B16F10 cells in vitro,through increasing the ratio of cell apoptosis and G2/S phage cycle arrest.Moreover,the combined strategy presented improved therapy efficacy against B16F10 melanoma xenograft without obvious systemic side effects in a nude mice model,which was likely related to both the enhanced tumor cell apoptosis and the increased proliferation of the CD3t/CD4t T-lymphocytes and CD3t/CD8t T-lymphocytes.Overall,the strategy of localized co-delivery of DOX/IL-2/IFN-g using the polypeptide hydrogel provided a promising approach for efficient melanoma therapy. | Qiang Lv Chaoliang He Fenli Quan Shuangjiang Yu Xuesi Chen | 2018 | Bioactive Materials2018，3，1： | 4 |
| 5 | Biocompatible in situ-forming glycopolypeptide hydrogels显示文摘A lack of biological activity hinders the application of synthetic hydrogels in tissue engineering and regenerative medicine.However,the use of glycopolypeptides in hydrogel synthesis may provide the materials with the desired biological activities.Herein,we prepared three in situ-forming hydrogels from various phenol-functionalized glycopolypeptides.The gelation time,mechanical properties,degradation properties,and biocompatibility of the hydrogels were assessed.Gelation time ranged from 11 to 380s,depending on the concentration of horseradish peroxidase.The galactose-modified polypeptide hydrogel showed the highest storage modulus with an obvious stress relaxation phenomenon.The prepared hydrogels exhibited good degradation properties and compatibility to cells and tissues.Furthermore,the rate of immune cell accumulation around the mannosemodified polypeptide hydrogel was the fastest among the hydrogels. | SHI Shun YU ShuangJiang LI Gao HE ChaoLiang CHEN XueSi | 2020 | Science China(Technological Sciences)2020，63，6： | 3 |
| 6 | Effect of interleukin-33 on Th1/Th2 cytokine ratio in peripheral lymphocytes in asthmatic mice显示文摘 | He Xinliang Wu Wei Lu Yan Guo Yali Hu Chaoliang Huang Yuyun Xu Yuzu Xie Jungang Zhao Jianping | 2014 | Chinese Medical Journal2014，，8： | 2 |
| 7 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 8 | Study of the synthesis, crystallization, and morphology of poly(ethylene glycol)-poly(ε-caprolactone) diblock eopolymers显示文摘 | He Chaoliang Sun Jingru Deng Chao | 2004 | Biomacro- molecules2004，5，5： | 1 |
| 9 | pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery显示文摘 | YU Shuangjiang HE Chaoliang DING Jianxun | 2013 | Soft Matter2013，9，9： | 1 |
| 10 | Recent advances in organic and polymeric carriers for local tumor chemo-immunotherapy显示文摘Combination therapy involves the simultaneous administration of compounds with varying mechanisms of action that can improve the efficacy of antitumor therapy and reduce toxicity.The most widely used combination regimen is chemotherapy combined with focused immunotherapy.This is implemented to induce the apoptosis of tumor cells and can activate immune responses,improving the clearance rate of primary lesions and maintaining the resistance to postoperative tumor recurrence and metastasis.Advances in micro/nanotechnology,nanomedicine and biomaterials have contributed to the development of enhanced local drug co-delivery systems for cancer treatment,improving tumor targeting and ameliorating severe systemic complications.Carrier materials can achieve the local long-term controllable release of multiple drugs,which not only avoids rapid drug diffusion from the pathological site,but can achieve synergistic effects at lower drug concentrations.Polymeric carriers display excellent biocompatibility and biodegradability;especially,some of them also have anti-tumor effects.The aim of this article was to review recent progress in the use of organic and polymeric materials for local tumor chemo-immunotherapy,which can be used as carriers for chemotherapeutic drugs,immune adjuvants and genes,including amphiphilic nanoparticles,nanocapsules,nano-disks,nano-polyplex particles,hydrogels and implantable materials. | BAI YiTing WANG TianRan ZHANG SongLing CHEN XueSi HE ChaoLiang | 2022 | Science China(Technological Sciences)2022，65，5： | 1 |
| 11 | Nano-composite of poly (L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility显示文摘 | HONG Zhongkui ZHANG Peibiao HE Chaoliang | 2005 | Biomaterials2005，，26： | 1 |
| 12 | Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite:Mechanical properties and biocompatibility显示文摘 | Hong Zhongkui Zhang Peibiao He Chaoliang | 2005 | Biomaterials2005，26，： | 1 |
| 13 | Nano-composite of poly (L-lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility 显示文摘 | Hong Zhongkui Zhang Peibiao He Chaoliang | 2005 | Biomaterials2005，26，32： | 1 |
| 14 | Nano-composite of poly( l -lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility显示文摘 | Zhongkui Hong Peibiao Zhang Chaoliang He Xueyu Qiu Aixue Liu Li Chen Xuesi Chen Xiabin Jing | 2005 | Biomaterials2005，，32： | 1 |
| 15 | Nano- composite of poly (L-lactide) and surface grafted hydroxyapatite: Mechanical properties and biocompatibility显示文摘 | Hong Zongkui Zhang Peibiao He Chaoliang | 2005 | Biomaterials2005，22，26： | 1 |
| 16 | Influence of residual chirality on the conformation and enzymatic degradation of glycopolypeptide based biomaterials显示文摘Glycopolypeptides as analogs of glycoproteins or glycosaminoglycans represent attractive building blocks for the construction of biomimetic biomaterials.However,the effects of amino acid chirality on the conformation and enzymatic degradation of glycopolypeptides are often overlooked.Here,we synthesized and characterized a range of glycopolypeptides composed of galactosylated poly(γ-propargylglutamate)s containing L-and/or D-glutamate residues.Glycopolypeptides containing pure Lglutamate residues were predominantlyα-helical,and the helicity increased over the degree of polymerization of the polypeptide backbones(24 to 44).The glycopolypeptide with pure D-glutamate residues adopted a mirroredα-helical conformation,whilst apparent random coil conformation was observed for the glycopolypeptide with equally mixed enantiomeric residues.The enzymatic degradation rates of the glycopolypeptides were markedly reduced following the introduction of D-glutamate residues into backbones.Galactoside pendants on these glycopolypeptides maintained their binding to peanut agglutinin.These structureproperty relationships provide new insight for the design of biomimetic biomaterials containing glycopolypeptides. | SHI Shun WANG JiaYu WANG TianRan REN Hui ZHOU YuHao LI Gao HE ChaoLiang CHEN XueSi | 2021 | Science China(Technological Sciences)2021，64，3： | 1 |
| 17 | Nanocomposite of poly ( L-lactide ) and surface grafted hydroxyapatite : mechanical properties and biocompatibility显示文摘 | Hong Zongkui Zhang Peibiao He Chaoliang | 2005 | Biomaterials2005，22，26： | 1 |
| 18 | Nano-composite of poly(L-lactide)and surface grafted hydroxyapatite:mechanical properties and biocompatibility显示文摘 | HONG Z K ZHANG P B HE Chaoliang | 2005 | Biomaterials2005，26，32： | 1 |
| 19 | Surface Modification of 316L Stainless Steel by Grafting Methoxy Poly(ethylene glycol) to Improve the Biocompatibility显示文摘 | XIAO Yanlong ZHAO Lei SHI Yongfeng LIU Ning LIU Yongli LIU Bin XU Qinghua HE Chaoliang CHEN Xuesi | 2015 | Chemical Research in Chinese Universities2015，31，4： | 1 |
| 20 | Graphene-Based E- lectro - chemical Sensors 显示文摘 | Shixin Wu Qiyuan He Chaoliang Tan Ya- dong Wang Hua Zhang | 2013 | Small2013，，： | 1 |
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