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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Prevalence of gastric varices and results of sclerotherapy with N-butyl 2 cyanoacrylate for controlling acute gastric variceal bleeding显示文摘AIM: To study the prevalence, predictors and control of bleeding following N-butyl 2 cyanoacrylate (NBC) sclerotherapy of gastric varix (GV). METHODS: We analyzed case records of 1436 patients with portal hypertension, who underwent endoscopy during the past five years for variceal screening or upper gastrointestinal (GI) bleeding. Fifty patients with bleeding GV underwent sclerotherapy with a mean of 2 mL NBC for control of bleeding. Outcome parameters were primary hemostasis (bleeding control within the first 48 h), recurrent bleeding (after 48 h of esophago- gastro-duodenoscopy) and in-hospital mortality were analyzed. RESULTS: The prevalence of GV in patients with portal hypertension was 15% (220/1436) and the incidence of bleeding was 22.7% (50/220). Out of the 50 bleeding GV patients, isolated gastric varices (IGV-I) were seen in 22 (44%), gastro-oesophageal varices (GOV) on lesser curvature (GOV-Ⅰ) in 16 (32%), and GOV on greater curvature (GOV-Ⅱ) in 15 (30%). IGV-Ⅰ was seen in 44% (22/50) patients who had bleeding as compared to 23% (39/170) who did not have bleeding (P < 0.003). Primary hemostasis was achieved with NBC in all patients. Re-bleeding occurred in 7 (14%) patients after 48 h of initial sclerotherapy. Secondary hemostasis was achieved with repeat NBC sclerotherapy in 4/7 (57%). Three patients died after repeat sclerotherapy, one during transjugular intrahepatic portosystemic stem shunt (TIPSS), one during surgery and one due to uncontrolled bleeding. Treatment failure-related mortality rate was 6% (3/50). CONCLUSION: GV can be seen in 15% of patients withportal hypertension and the incidence of bleeding is 22.7%. NBC is highly effective in controlling GV bleeding. In hospital mortality of patients with bleeding GV is 6%. | Khalid Mumtaz Shahid Majid Hasnain A Shah Kashif Hameed Ashfaq Ahmed Saeed Hamid Wasim Jafri | 2007 | World Journal of Gastroenterology2007，13，8： | 12 |
| 3 | 芜菁的诱导同源四倍体减数分裂分析(英文)显示文摘细胞学上芜菁 (Brassicarapa)为正常的二倍体 ,具有 1 1的联会和 1 - 1的染色体分离。它的花粉母细胞 (PMC’s )在小孢子发生过程中的减数分裂前期 (M1 )无“B染色体” ,也无任何次级缔合。用 0 0 2 %的秋水仙碱水溶液处理 6h对多倍体的诱导形成明显。诱导出的同源四倍体构型中无联会基因 ,而成 1或 2次交叉的二价体、三价体和四价体。从多倍体逆转的有趣现象中发现 ,4 6 7%的诱导多倍体后来恢复成二倍体。不平衡的染色体分离普遍存在于诱导出的同源四倍体中 ,这就是导致生存能力不同的异常配子体出现的主要原因。异常配子体的结合 ,在芸苔属 (Brassica) | Habib Ahmad Shahida Hasnain | 2004 | 云南植物研究2004，26，3： | 12 |
| 4 | Predictive factors for early aspiration in liver abscess显示文摘AIM: To determine the predictive factors for early aspiration in liver abscess. METHODS: A retrospective analysis of all patients with liver abscess from 1995 to 2004 was performed. Abscess was diagnosed as amebic in 661 (68%) patients, pyogenic in 200 (21%), indeterminate in 73 (8%) and mixed in 32 (3%). Multiple logistic regression analysis was performed to determine predictive factors for aspiration of liver abscess. RESULTS: A total of 966 patients, 738 (76%) male, mean age 43 ± 17 years, were evaluated: 540 patients responded to medical therapy while adjunctive percutaneous aspiration was performed in 426 patients. Predictive factors for aspiration of liver abscess were: age ≥ 55 years, size of abscess ≥ 5 cm, involvement of both lobes of the liver and duration of symptoms ≥ 7 d. Hospital stay in the aspiration group was relatively longer than in the non aspiration group. Twelve patients died in the aspiration group and this mortality was not statistically significant when compared to the non aspiration group. CONCLUSION: Patients with advanced age, abscess size > 5 cm, both lobes of the liver involvement and duration of symptoms > 7 d were likely to undergo aspiration of the liver abscess, regardless of etiology. | Rustam Khan Saeed Hamid Shahab Abid Wasim Jafri Zaigham Abbas Mohammed Islam Hasnain Shan Shaalan Beg | 2008 | World Journal of Gastroenterology2008，14，13： | 8 |
| 5 | Prevalence of non-Helicobacter pylori duodenal ulcer in Karachi,Pakistan显示文摘AIM: To determine the prevalence of non-Helicobacter pylori (H pylori)-related duodenal ulcer in patients with acid-peptic diseases.METHODS: Medical records of patients who attended the Gastroenterology Department at Aga Khan University Hospital from 1999 to 2001 and had endoscopic diagnosis of duodenal ulcers were reviewed. Duodenal ulcer associated with H pylori was diagnosed on the basis of endoscopy,rapid urease test and histopathology whereas histories of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) related duodenal ulcers. Non-H pylori, non-NSAID duodenal ulcers were those without H pylori infection and history of NSAID intake. Co-morbid conditions associated were noted.RESULTS: Of 2 260 patients, 10% (217/2 260) had duodenal ulcer. Duodenal ulcer related to H pylori infectionaccounted for 53% (116/217), NSAID-related 10% (22/217),non-H pylori non-NSAID 29% (62/217), and 8% (17/217) had both Hpyloriinfection and histories of NSAID intake. Fifteen percent (18/116)_patients had past histories of peptic ulcer disease in Hpyloriinfection, while 8% (5/62) in non-Hpylorinon-NSAID ulcer. Co-morbid conditions in H pylori infection were seen in 23% (27/116) and 34%(21/62) in non-H pylori non-NSAID ulcer.CONCLUSION: Incidence of H pylori infection related with duodenal ulcer is common. In the presence of co-morbids, non-Hpyloriand non-NSAID duodenal ulcer is likely to be present. | Javed Yakoob Wasim Jafri Nadim Jafri Muhammad Islam Shahab Abid Saeed Hamid Hasnain AliShah Hizbullah Shaikh | 2005 | World Journal of Gastroenterology2005，11，23： | 6 |
| 6 | Grain size and geochemical partitioning of heavy metals in sediments of the Damodar River – a tributary of the lower Ganga, India显示文摘 | A. K. Singh S. I. Hasnain D. K. Banerjee | 1999 | Environmental Geology1999，，1： | 2 |
| 7 | Candida esophagitis:Risk factors in non-HIV population in Pakistan显示文摘AIM:Candida esophagitis is a frequent infection in immunocompromised patients. This study was designed to determine its characteristics in non- human immune deficiency virus (HIV) infected patients attending a teaching hospital.METHODS: Clinical records of all patients coded by international classification of diseases 9th revision with clinical modifications'(ICD-9-CM), with candida esophagitis diagnosed by esophagogastroduodenoscopy (EGD) and histopathology over a period of 5 years were studied.RESULTS: Fifty-one patients (27 males, 24 females, range 21-77 years old and mean age 52.9 years) fulfilled the criteria (0.34% of the EGD). The common predisposing factors were carcinoma (OR 3.87, CI 1.00-14.99) and diabetes mellitus (OR 4.39, CI 1.34-14.42). The frequent clinical symptoms were retrosternal discomfort, dysphagia and epigastric abdominal pain with endoscopic appearance of scattered mucosal plaques. Another endoscopic lesion was associated with candida esophagitis in 15% patients.CONCLUSION: Carcinomas, diabetes mellitus, corticosteroid and antibiotic therapy are major risk factors for candida esophagitis in Pakistan. It is an easily managed complication that responds to treatment with nystatin. | Javed Yakoob Wasim Jafri Shahab Abid Nadeem Jafri Muhammad Islam Saeed Hamid Hasnain A Shah Akbar S Hussainy | 2003 | World Journal of Gastroenterology2003，9，10： | 2 |
| 8 | A high-throughput data analysis and materials discovery tool for strongly correlated materials显示文摘Modeling of f-electron systems is challenging due to the complex interplay of the effects of spin–orbit coupling,electron–electron interactions,and the hybridization of the localized f-electrons with itinerant conduction electrons.This complexity drives not only the richness of electronic properties but also makes these materials suitable for diverse technological applications.In this context,we propose and implement a data-driven approach to aid the materials discovery process.By deploying state-of-the-art algorithms and query tools,we train our learning models using a large,simulated dataset based on existing actinide and lanthanide compounds.The machine-learned models so obtained can then be used to search for new classes of stable materials with desired electronic and physical properties.We discuss the basic structure of our f-electron database,and our approach towards cleaning and correcting the structure data files.Illustrative examples of the applications of our database include successful prediction of stable superstructures of double perovskites and identification of a number of physically-relevant trends in strongly correlated features of f-electron based materials. | Hasnain Hafiz Adnan Ibne Khair Hongchul Choi Abdullah Mueen Arun Bansil Stephan Eidenbenz John Wills Jian-Xin Zhu Alexander V.Balatsky Towfiq Ahmed | 2018 | npj Computational Materials2018，，1： | 2 |
| 9 | Grain size and geochemical partitioning of heavy metals in sediments of the Damodar River – a tributary of the lower Ganga, India显示文摘 | A. K. Singh S. I. Hasnain D. K. Banerjee | 1999 | Environmental Geology1999，，1： | 2 |
| 10 | ACE I/D and G2350A polymorphisms in Pakistani hypertensive population of Pun iab显示文摘 | Alvi FM Hasnain S | 2009 | Clin Exp Hypertens2009，31，5： | 1 |
| 11 | Grain size and geochemical partitioning of heavy metals in sediments of the Damodar River--a tributary of the lower Ganga, India显示文摘 | Singh A K Hasnain S I Banerjee D K | 1999 | Environmental geology1999，39，1： | 1 |
| 12 | Studies on the re- covery of sludge protein 显示文摘 | Chishti S S Hasnain S N Khan M A | 1992 | Water Research1992，26，2： | 1 |
| 13 | Antibiotic susceptibility pattern and multiple antibiotic resistances (MAR) calculation of extended spectrum 13-1actamase (ESBL) producing Escherichia coli and Klebsiella species in Pakistan 显示文摘 | Riaz S Faisal M Hasnain S | 2013 | African Journal of Biotechnology2013，10，33： | 1 |
| 14 | Heterologous Metalloprotein Biosynthesis in Escherichia Coll: Conditions for the Overproduction of Functional Copper-Containing Nitrite Reductase and Azurin From Alcaligenes Xylosoxidans显示文摘 | Harris R L PrudeAncio M Hasnain S S | 2005 | J Synchrotron Rad2005，12，： | 1 |
| 15 | Patient-cen- tered care for Muslim women:Provider and patient per- spectives显示文摘 | Hasnain M Connell K J Menon U | 2011 | J Womens Health (Larchmt)2011，20，1： | 1 |
| 16 | Low cost removal of disperse dye from aqueous solution using palm ash显示文摘 | TSA M Hasnain LANG Lee Siew ASAARI Faridah A H | 2007 | Dyes and Pigments2007，74，： | 1 |
| 17 | Conformational vari- ability of the Cu site in one subunit of bovine CuZn superoxide dismu- tase: the importance of mobility in the Glu119-Leu142 loop region for catalytic function显示文摘 | HOUGH M A STRANGE R W HASNAIN S S | 2000 | J Moi Bioi2000，304，2： | 1 |
| 18 | Coupling of PV-powered RO brackish water desalination plant with solar stills显示文摘 | HASNAIN S M ALAJLAN S A | 1998 | Desalination1998，116，： | 1 |
| 19 | Review on sustainable thermal storage technologies, Part1: Heat storage material and techniques显示文摘 | S M Hasnain | 1998 | Energy Convers Mgmt and1998，11，： | 1 |
| 20 | Molybdate inhibition of sul- phate reduction in two-phase anaerobic digestion 显示文摘 | HASNAIN I M ANDERSON G K | 2005 | Process Biochemistry2005，40，6： | 1 |
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