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| 1 | Dietary copper triggers onset of fulminant hepatitis in the Long-Evans cinnamon rat model显示文摘AIM:To investigate the impact of dietary copper given at different time points on the onset of fulminant hepatitis. METHODS:The Long-Evans cinnamon (LEC) rat model of Wilson's disease (WD) was used to study the impact of high dietary copper (hCu) on the induction of fulminant hepatitis at early or late time points of life. High Cu diet was started in rat pups or in adults (month 5) for three months. Animals that received reduced dietary copper (rCu) throughout their lifetime served as a control. Hepatitis-associated serum markers (alanine aminotransferase, aspartate transaminase, bilirubin) were analyzed in animal groups receiving hCu or rCu. Liver copper content and liver histology were revealed at sacrifice. A set of 5 marker genes previously found to be affected in injured liver and which are related to angiogenesis (Vegfa), fat metabolism (Srebf1), ex-tracellular matrix (Timp1), oxidative stress (Hmox1), and the cell cycle (Cdkn1a) were analyzed by real-time polymerase chain reaction. RESULTS:Regardless of the time point when hCu was started, LEC rats (35/36) developed fulminant hepatitis and died. Animals receiving rCu (36/36) remained healthy, did not develop hepatitis, and survived long term without symptoms of overt disease, although liver copper accumulated in adult animals (477 ± 75 μg/g). With regard to start of hCu, onset of fulminant hepatitis was significantly (P < 0.001) earlier in adults (35 ± 9 d) that showed pre-accumulation of liver copper as compared to the pup group (77 ± 15 d). Hepatitis-associated serum markers, liver copper and liver histology, as well as gene expression, were affected in LEC rats receiving hCu. However, except for early and rapid onset of hepatitis, biochemical and molecular markers were similar at the early and late time points of disease. CONCLUSION:Rapid onset of fulminant hepatitis in asymptomatic LEC rats with elevated liver copper suggests that there is a critical threshold of liver copper which is important to trigger the course of WD. | Ramsi Siaj Vanessa Sauer Sandra Stppeler Hans-Ullrich Spiegel Gabriele Khler Andree Zibert Hartmut HJ Schmidt | 2012 | World Journal of Gastroenterology2012，18，39： | 3 |
| 2 | 带双质量飞轮的动力传动系统各种工况的仿真显示文摘节约实车试验和减少开发周期和成本的一个必不可少的工具是通过各种行驶条件下的仿真来确定双质量飞轮(DMF)的最优参数。另外,仿真还能确定应用于当前设计的新方法的效能。 | Hartmut Bach Wolfgang Kücks Michael Triebel ZF Sachs AG Schweinfurt | 2008 | 传动技术2008，22，3： | 3 |
| 3 | Determination of total aryte- noids and chlorophylls a and b of leaf extracts in differ- ent solvents显示文摘 | Hartmut K L Alan R W | 1983 | Bioche Soc Trans1983，11，： | 1 |
| 4 | Determinations of total carotenoids and chlorophylls b of leaf extracts in different solvents显示文摘 | Hartmut K | 1983 | Analysis (Peach K & Tracey MV eds)1983，1983，4： | 1 |
| 5 | Very High-Frequency Radar Mapping of Surface Currents显示文摘 | SHAY L K COOK T M HARTMUT P | 2002 | IEEE Journal of Oceanic Engineering2002，27，2： | 1 |
| 6 | Chlorophylls and cartenoids:Pigments of photosynthetic biomembranes显示文摘 | HARTMUT K LICHLENTHALER | 1987 | Methods in Enzymology1987，148，： | 1 |
| 7 | Detection of p53 Gene Mutations in Exhaled Breath Condensate of Non-Small Cell Lung Cancer Patients显示文摘 | Christian G Hartmut K Katja T | 2009 | Lung Cancer2009，64，2： | 1 |
| 8 | Chronic inflammatory cardiomyopathy of interferon-overex- pressing transgenic ,nice is mediated by tumor necrosis factor-a显示文摘 | Michael T Philip W Hartmut K | 2012 | Am J Pathol2012，180，1： | 1 |
| 9 | Species identification of cooked fish by urea isoelectric focusing and sodium dodecylsulfate polyacrylamide gel electrophoresis, a collaborative study显示文摘 | Hartmut T Rainer K Ingrid M | 1999 | Food Chemistry1999，，67： | 1 |
| 10 | Polypeptide-shelled poly(propylene imine) dendrimers and their complexing properties towards copper (Ⅱ) ions显示文摘 | Dietmar A Hartmut K Ralf K | 2005 | Macromolecular Rapid Communications2005，26，8： | 1 |
| 11 | Dynamics of Notch expression during murine prostate development and tumorigenesis显示文摘 | Jianyong S Sarajane R Hartmut K | 2001 | Cancer Research2001，61，： | 1 |
| 12 | Determinations of total carotenoids and chlorophyll a and b of leaf extracts in different solvents显示文摘 | Hartmut K | 1983 | Biochemical Society transactions1983，11，： | 1 |
| 13 | Detection of photosyntheticactivity and water stress by imaging the red chlorophyllfluorescence显示文摘 | Hartmut K Lichtenthaler Fatbardha B | 2000 | Plant Physiol Bio-chem2000，38，： | 1 |
| 14 | Lipoxygenase-dependent degradation of storage lipids显示文摘 | Ivo F Hartmut K Claus W | 2001 | Trends in Plant Science2001，6，6： | 1 |
| 15 | Species identification of formed fishery products and high pressure-treated fish by electrophoresis:a collaborative study显示文摘 | Monique Etienne Marc Jér(o)me Jo(e)l Fleurence Hartmut Rehbein Rainer Kündiger Rogério Mendes Helena Costa and Iciar Martínez | 2001 | Food Chemistry2001，72，1： | 1 |
| 16 | Crystallization of insensitive HMX显示文摘 | Hartmut K | 2008 | Propellants Explosives Pyrotechnics2008，33，1： | 1 |
| 17 | Species identification of cooked fish by urea isoelectric focusing and sodium dodecylsulfate polyacrylamide gel electrophoresis:a collaborative study显示文摘 | Hartmut Rehbein Rainer Kündiger Ingrid Malmheden Yman Monica Ferm Monique Etienne Marc Jerome Anne Craig lan Mackie Flemming Jessen Iciar Martinez | 1999 | Food Chemistry1999，67，4： | 1 |
| 18 | 显示文摘 | Anindita G Susanta B Hartmut K | 2010 | Macromolecules2010，43，： | 1 |
| 19 | in vitro determination of the allergenic potential of technologically altered hen's egg显示文摘 | SABINE H HARTMUT D K RODOLPHE | | 0，，05： | 1 |
| 20 | Sarcoma of follicular dendritic cells with features of sinus lining cells-a new subtype of retieulum cell sarcoma?显示文摘 | Manuela K Hartmut M Christoph T | 2008 | Virchows Arch2008，452，5： | 1 |
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