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| 1 | Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging显示文摘BACKGROUND The nature of input data is an essential factor when training neural networks.Research concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly advancing.Still,evidence to support the utilization of multi-dimensional and multi-parametric image data is lacking.Due to higher information content,three-dimensional input should presumably result in higher classification precision.Also,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI images.AIM To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(DenseNet)for FLLs on multi-sequence MRI.METHODS We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FNH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FNH,69 HCC and 76 MET.After volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-DenseNet264 network.Identical bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-DenseNet264 model.The test set consisted of 10-10-10 tumors.The performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(NPV),and f1 scores.RESULTS The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,NPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FNH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D models.The 2D and 3D networks'performance in the diagnosis of HCC were 1.00,0.80,0.91,1.00,and 0.89 and 0.88,0.70,0.86,0.95,and 0.78,respectively;while the evaluation of MET lesions resulted in 0.91,1.00,1.00,0.95,and 0.95 and 0.75,0.90,0.94,0.85,and 0.82 using the 2D and 3D networks,respectively.CONCLUSION Both 2D and 3D-DenseNets can differentiate FNH,HCC and MET with good accuracy when trained on hepatocyte-specific contrast-enhanced multi-sequence MRI volumes. | Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál N Kaposi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 2 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 3 | High-performance waveguide-integrated germanium PIN photodiodes for optical communication applications[Invited]显示文摘This paper reports on high-performance waveguide-integrated germanium photodiodes for optical communications applications.200 mm wafers and production tools were used to fabricate the devices.Yields over 97%were obtained for three different compact photodiodes(10×10μm and intrinsic region width of 0.5,0.7,and 1μm)within the same batch of three wafers.Those photodiodes exhibit low dark currents under reverse bias with median values of 74,62,and 61 nA for intrinsic widths of 0.5,0.7,and 1μm,respectively,over a full wafer.Responsivities up to 0.78 A∕W at 1550 nm and zero bias were measured.Zero bias operation is possible for 25 and 40 Gbps with receiver sensitivity estimated to−13.9 and−12.3 dBm,respectively. | Léopold Virot Laurent Vivien Jean-Marc Fédéli Yann Bogumilowicz Jean-Michel Hartmann Frédéric Bœuf Paul Crozat Delphine Marris-Morini Eric Cassan | 2013 | Photonics Research2013，1，3： | 2 |
| 4 | 25 Gbps low-voltage hetero-structured silicongermanium waveguide pin photodetectors for monolithic on-chip nanophotonic architectures显示文摘Near-infrared germanium(Ge) photodetectors monolithically integrated on top of silicon-on-insulator substrates are universally regarded as key enablers towards chip-scale nanophotonics, with applications ranging from sensing and health monitoring to object recognition and optical communications. In this work, we report on the highdata-rate performance pin waveguide photodetectors made of a lateral hetero-structured silicon-Ge-silicon(Si-Ge-Si) junction operating under low reverse bias at 1.55 μm. The pin photodetector integration scheme considerably eases device manufacturing and is fully compatible with complementary metal-oxide-semiconductor technology. In particular, the hetero-structured Si-Ge-Si photodetectors show efficiency-bandwidth products of^9 GHz at-1 V and ~30 GHz at-3 V, with a leakage dark current as low as ~150 nA, allowing superior signal detection of high-speed data traffic. A bit-error rate of 10-9 is achieved for conventional 10 Gbps, 20 Gbps, and25 Gbps data rates, yielding optical power sensitivities of-13.85 dBm,-12.70 dBm, and-11.25 dBm, respectively. This demonstration opens up new horizons towards cost-effective Ge pin waveguide photodetectors that combine fast device operation at low voltages with standard semiconductor fabrication processes, as desired for reliable on-chip architectures in next-generation nanophotonics integrated circuits. | DANIEL BENEDIKOVIC LéOPOLD VIROT GUY AUBIN FARAH AMAR BERTRAND SZELAG BAYRAM KARAKUS JEAN-MICHEL HARTMANN CARLOS ALONSO-RAMOS XAVIER LE ROUX PAUL CROZAT ERIC CASSAN DELPHINE MARRIS-MORINI CHARLES BAUDOT FRéDéRIC BOEUF JEAN-MARC FéDéLI CHRISTOPHE KOPP LAURENT VIVIEN | 2019 | Photonics Research2019，7，4： | 2 |
| 5 | Efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopedic surgery: findings from the ORTHO‐TEP registry显示文摘 | J. BEYER‐WESTENDORF J. LüTZNER L. DONATH O. C. RADKE E. KUHLISCH A. HARTMANN N. WEISS S. WERTH | 2012 | Journal of Thrombosis and Haemostasis2012，，10： | 1 |
| 6 | Room temperature ferromagnetism in Mn -doped ZnO films mediated by acceptor de- fects显示文摘 | Xu Q Schmidt H Hartmann L | 2007 | Appl Phys Lett2007，91，09： | 1 |
| 7 | Molecular cloning of SVP: a negative regulator of the floral transition in Ar- abidopsis显示文摘 | Hartmann U Hohmann S Nettesheim K et a l | 2000 | The Plant Journal2000，21，4： | 1 |
| 8 | A rechargeable room-temperature sodium superoxide (NaOz) battery显示文摘 | Hartmann P Bender C L Vracar M | 2013 | Nature Materials2013，12，3： | 1 |
| 9 | Primary ovarian tumors显示文摘 | Davis K P Hartmann L K Keeney G L | 1996 | Gynecol Oncol1996，61，2： | 1 |
| 10 | Structure studies of oligonucleotides containing Gquadruplex motifs using AFM显示文摘 | COSTA L T KERKMANN M HARTMANN G | 2004 | Biochem Biophys Res Commun2004，313，4： | 1 |
| 11 | The life cycle of the northern hemisphere sudden stratospheric warmings显示文摘 | Limpasuvan V Thompson D W J Hartmann D L | 2004 | Journal of Climate2004，17，13： | 1 |
| 12 | On the use of Earth radiation budget statistics for studies of clouds and climate显示文摘 | Dennis L Hartmann and David A Short | 1980 | Journal of the Atmospheric Sciences1980，37，： | 1 |
| 13 | Transition-metal ions in alu- minophosphate and silicoaluminophosphate molecular sieves: Location, interaction with adsorbates and catalytic properties显示文摘 | Hartmann M Kevan L | 1999 | Chem Rev1999，99，3： | 1 |
| 14 | Recovery of placer gold using the Knelson Concentrator显示文摘 | MEZA L A HARTMANN W ESCOBAR C A | 1994 | Innovations in Mineral Processing1994，，1： | 1 |
| 15 | Occurrence of CTXM producing Escherichia coli in soils,cattle,and farm environment in France(Burgundy region)显示文摘 | Hartmann A Locatelli A Amoureux L | 2012 | Front Microbiol2012，，3： | 1 |
| 16 | Fructans in the diet cause alterations of intestinal mucosal architecture, released mucins and mucosa-associated Bifidobacteria in gnotobiotic rats 显示文摘 | Kleessen B Hartmann L Blaut M | 2003 | BrJ Nutr2003，89，： | 1 |
| 17 | Eddy-zonal flow feedback in the northern hemisphere winter显示文摘 | Lorenz D J Hartmann D L | 2003 | J Climate2003，16，8： | 1 |
| 18 | Oligofructose and longchain inulin:influence on the gut microbial ecology of rats associated with a human faecal flora显示文摘 | KLEESSEN B HARTMANN L BLAUT M | | 0，，02： | 1 |
| 19 | Standardization of near-Infrared spectrometric instruments显示文摘 | Bouveresse E Hartmann C Massart D L | | 0，，06： | 1 |
| 20 | Vertical structure of tropical oceanic convective clouds and its relation to precipitation 显示文摘 | Kubar T L Hartmann D L | 2008 | Geophysical Research Letters2008，35，3： | 1 |
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