|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 器官移植受体发生EBV阳性的皮肤黏膜溃疡:一种局限性惰性移植后淋巴组织增殖性疾病显示文摘Epstein-Barr 病毒( EBV )阳性的皮肤黏膜溃疡( EBV MCU)是在老人或医源性免疫受损患者中发生的一种B细胞淋巴组织增殖性疾病,尚未见发生于实体器官移植受者的报道。作者在70例EBV阳性移植后淋巴组织增殖性疾病( PTLD)患者中发现7例EBV阳性MCU。包括5例肾脏、1例心脏和1例肺脏移植,其中男性5例。患者中位年龄61岁,4例发生于口腔黏膜,3例发生于胃肠道。溃疡病变发生前患者接受免疫抑制治疗0.6-13年。溃疡由炎症细胞和多形性或单形性大细胞增生,破坏皮肤黏膜而形成。5例中可见Reed-Sternberg样细胞。所有病例CD20、CD30阳性,原位杂交EBER结果阳性。3例近期患者被诊断为EBV阳性MCU,4例患者前期被诊断为单形性大细胞PTLD(n=3)和多形性 PTLD ( n =1)。所有患者血液 EBV DNA 均阴性(〈1000拷贝数/ml),而在诊断或随访的44例移植患者中有35例发生系统性 PTLD ( P 〈0.001)。所有 EBV 阳性MCU患者通过减少免疫抑制剂用量(7/7),调整免疫抑制剂用量(2/7),和联用利妥昔单抗(3/7)等使皮损得到治愈。目前5例存活:其中4例身体健康,1例在等待肾移植手术;另2例分别在EBV阳性MCU治愈后的3年和5年死亡。未发现EBV阳性MCU复发或其他PTLD。 | Hart M Thakral B Yohe S 胡舜摘 余英豪 | 2014 | 临床与实验病理学杂志2014，30，12： | 5 |
| 2 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet2010，，9726： | 4 |
| 3 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | 2010 (9726)2010，，9726： | 3 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 6 | Voltammetric behavior of ascorbic acid at a graphite-epoxy composite electrode chemically modified with cobalt phthalocyanine and its amperometric determination in multivitamin preparations显示文摘 | Wring S A Hart J P Birch B J | 1990 | Anal Chim Acta1990，229，： | 2 |
| 7 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 8 | Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial显示文摘 | Wendy S Atkin Rob Edwards Ines Kralj-Hans Kate Wooldrage Andrew R Hart John MA Northover D Max Parkin Jane Wardle Stephen W Duffy Jack Cuzick | 2010 | The Lancet . 2010 (9726)2010，，： | 2 |
| 9 | Chemical Geodynamics显示文摘 | A Zindler S Hart | 1986 | Annual Review of Earth and Planetary Sciences1986，，： | 2 |
| 10 | The costs and benefits of ownership: A theory of vertical and lateral integration显示文摘 | Grossman S O Hart | 1986 | Journal of Political Economy1986，94，： | 1 |
| 11 | An analysis of the principalagent problem显示文摘 | Grossman S J Hart O D | 1983 | Econometrica1983，51，： | 1 |
| 12 | High rates of nitrification and nitrate turnover in undisturbed coniferous forests显示文摘 | Stark J M Hart S C | 1997 | Nature1997，385，： | 1 |
| 13 | The fortune at the bottom of the pyramid 显示文摘 | Prahalad C K Hart S L | 2002 | Strategy + Business2002，26，： | 1 |
| 14 | Real time Evolved Gas Analysis by FTIR Method: An Experimental Study of Cellulose Pyrolysis显示文摘 | Li S Lyons Hart J Banyasz J | 2001 | Fuel2001，80，12： | 1 |
| 15 | An analysis of the principalagent problem显示文摘 | Hart O | 1983 | Econometrica1983，51，： | 1 |
| 16 | One Share-One Vote and the Market for Corporate Control显示文摘 | Grossman S O Hart | 1988 | Journal of Financial Economics1988，20，： | 1 |
| 17 | 13C andl5N natural abundance of the soil microbial biomass显示文摘 | Dijkstra P Ishizu A Doucett R Hart S C Schwartz E Menyailo O V Hungate B A | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 18 | Synthesis ofdimethylcarbonate by vapor phase oxidative carbonylation of methanol over Cu-based catalysts显示文摘 | Hart M S Lee B G Ahn B S | 2001 | Journal of Molecular Catalysis2001，170，1： | 1 |
| 19 | Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis显示文摘 | Hart ison S A To rgerson S Hayashi P | 2003 | Am J Gastroenterol2003，98，： | 1 |
| 20 | An analysis of the principal-agent problem 显示文摘 | Grossman S Hart O | 1983 | Econometrica1983，51，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员