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183篇 您的检索式：作者名="HART F J"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Evalution of the airtraq and macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation 显示文摘	MAHARAJ C H COSTELLO J F HARTE B H	2008	Anaesthesia2008，63，2：	1
3	Analysis of eighty-one cases with breast lesions using automated breast volume scanner and comparison with handheld ultrasound 显示文摘	Lin X Wang J Hart F	2012	Eur J Radiol2012，81，5：	1
4	Carbon nitride: Ab initio investigation of carbon-rich phases 显示文摘	HART J N CLEAYSSENS F ALLAN N L	2009	Phys Rev B2009，80，17：	1
5	From bijels to picketing emulsions: a lattice Boltzmann study显示文摘	Jansen F Harting J	2011	Phys Rev E2011，83，04：	1
6	Prognostic value of bcl-2 oncoprotein expression in stage II colon carcinoma显示文摘	Sinicrope FA Hart J Michelassi F	1995	Clin Cancer Res1995，1，10：	1
7	Effects of removal of a small dam on downstream macroinvertebrate and algal assemblages in a Pennsylvania stream显示文摘	THOMSON J R HART D D CHARLES D F	2005	Journal of the North American Benthological Society2005，24，1：	1
8	A long-lasting interferon-gamma response is induced to a single inoculation of antigen-pulsed dendritic cells显示文摘	Dillon S M Griffon J F Hart D N	2006	Immunology2006，103，1：	1
9	Addition of metformin to exogenous glucagon-like peptide-I results in in- creased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus显示文摘	Cuthbertson J Patterson S O' Harte F P	2011	Me- tabolism2011，60，1：	1
10	GDF5 single-nu- cleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women 显示文摘	Williams F M Popham M Hart D J	2011	Arthritis Rheum2011，63，3：	1
11	GDF5 single nucleotide polymorr phism rs143383 is associated with lumbar disc degeneration inNorthern European women显示文摘	Williams F M Popham M Hart D J de Schepper E Bierma Zeinstra S Hofman A	2011	Arthritis Rheum2011，63，：	1
12	Preliminary results of combined ESR/U-series dating of fossil teeth from Longgupo cave, China显示文摘	Hart F Bahain J J Boeda E	2012	Quaternary Geochronology2012，10，：	1
13	Antithrombotic therapy in cerebrovaseular disease 显示文摘	Rothrock J F Hart R G	1991	Ann Intern Med1991，115，11：	1
14	Three dimensional ana- lytical simulation of flexible pipe wall structure显示文摘	McNamara J F Harte A M	1992	Journal of Offshore Mechanics and Arctic Engineer- ing1992，114，2：	1
15	Cruising Speed of Goldfish in relation to water temperature显示文摘	Fry F E J Hart J S	1948	Journal of the Fisheries Research Board of Canada1948，7，：	1
16	flavonoid variation in eurasian sedum and sempervivum 显示文摘	Stevens J F Hart H	1996	Phytochemistry1996，41，2：	1
17	Variation of Mo isotopes from molybdenite inhigh-temperature hydrothermal ore deposits显示文摘	Mathur R Brantley S Anbar A Munizaga F Maksaev V Newberry R Vervoort J Hart G	2010	Miner Deposita2010，45，：	1
18	Factors affecting the stability ofaqueous potassium ferrate(VI)solution显示文摘	Wagner W F Gump J R Hart E N	1952	Anal Chem1952，24，：	1
19	Storing elastic energy in carbon nanotubes 显示文摘	HILL F A HAVEL T F HART A J	2009	Journal of Micromechanics and Microengineering2009，19，09：	1
20	Elevated endotoxin levels in non-alcoholic fatty liver disease显示文摘	Harte A L Silva N F D Creely S J	2010	J Inflamm2010，7，：	1

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