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    题名 作者 年代 出处 被引量
1柴达木盆地北缘古生代超高压带中花岗质岩浆作用显示文摘祁连南缘古生代超高压变质带 (榴辉岩年龄为 4 6 6~ 4 95 Ma)上一套中高级变质岩系 (达肯大坂片麻岩 )中存在三类花岗岩组合 : 类 :石英二长闪长岩 -花岗闪长岩 -二长花岗岩 , 类 :二长花岗岩 -二云母花岗岩-含白云母花岗岩 -正长花岗岩 , 类 :花岗闪长岩 -二长花岗岩 -黑云母花岗岩。 类岩石组合中的二长花岗岩锆石SHRIMP年龄为 4 73Ma, 类岩石组合中的正长花岗岩锆石 SHRIMP年龄为 4 4 6 Ma, 类岩石组合中的二长花岗岩锆石 SHRIMP年龄为 397Ma。从三类花岗岩组合的组成矿物来看 , 类和 类的矿物组合主要为斜长石、角闪石、石英、碱性长石、黑云母 , 类的矿物组合为钾长石、石英、白云母、黑云母、斜长石 ;从岩石地球化学特征上看 , 类和 类花岗岩为 型花岗岩 ,岩石的 Si O2 =6 1%~ 6 9% ,Na2 O/ K2 O>1,ANK<1,δEu=0 .7~ 1.0 ; 类花岗岩为 S型花岗岩 ,岩石的 Si O2 =70 %~ 76 % ,Na2 O/ K2 O<1,ANK>1,δEu=0 .1~ 0 .3;从构造环境上看 , 类花岗岩形成于岛弧环境或活动大陆边缘 , 类花岗岩形成于同碰撞 , 类花岗岩形成于碰撞后。结合区域地质特征 ,我们认为 ,早奥陶世 ,南祁连洋板块向北俯冲于祁连陆块之下 ,规模不大的南祁连洋很快闭合 ,但俯冲下去的大洋板块仍拖动柴达木陆块继续俯冲 ,俯冲?吴才来 杨经绥 许志琴 Joseph L.WOODEN Trevor IRELAND 李海兵 史仁灯 孟繁聪 陈松永 Harold PERSING Anders MEIBOM 2004地质学报2004,78,5:91
2急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南(续前)显示文摘7静脉溶栓 7.1静脉rtPA 急性卒中的静脉溶栓治疗现已得到普遍接受。美国FDA于1996年批准静脉应用rtPA,部分基于NINDSrtPA卒中试验结果。Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) 2013国际脑血管病杂志2013,21,8:975
3乙型肝炎病毒基因型和血清亚型在我国部分地区的分布及其特点显示文摘目的 研究乙型肝炎病毒 (hepatitisBvirus ,HBV)基因型和血清亚型的分布特点及其基因的相关性。方法 湖南、广西、河南和河北 4省 (区 ) 2 5个县 (市 ) 2 80例慢性HBV携带者 ,应用聚合酶链反应 (PCR)扩增和脱氧核糖核酸 (DNA)序列分析 ,确定HBV基因型和血清亚型。结果 HBV基因型B、C和D均有分布 ,分别占 2 9.3%、6 7.9%和 2 .9% ,其中B和C为优势基因型。adr、adw2、ayr、ayw1、ayw2和ayw3等 6种血清亚型均有分布 ,其中adr和adw2为优势血清亚型 ,分别占6 4.3%和 31.4%。基因型B与adw2血清亚型 ,基因型C与adr血清亚型有非常密切的基因相关性。 2 80例HBV携带者表面抗原基因序列每 10 0个核苷酸的平均置换频数为 2 .94。基因型B(adw2血清亚型 )毒株核苷酸置换频数为 5 .6 3(5 .48) ,而基因型C(adr血清亚型 )仅为 1.6 (1.5 1)。结论 HBV基因型和血清亚型的分布均有明显的地区性 ;基因型B及相对应的adw2血清亚型毒株的基因可变性明显高于基因型C及相应的adr血清亚型。夏国良 Omana V Nainan 贾志远 刘洪斌 罗述斌 李荣成 曹慧霖 刘崇柏 HaroldS Margolis 2001中华流行病学杂志2001,22,5:131
4基础骨生物学新观显示文摘黎小坚 Harold M Frost 朱绍舜 柯华珠 2001中国骨质疏松杂志2001,7,2:73
5缺血性卒中患者的早期处理指南——美国卒中学会卒中委员会科学声明显示文摘1994年,美国心脏学会(AHA)卒中委员会委托一个专门研究小组撰写了急性缺血性卒中患者的处理指南[1].1996年,在静脉rtPA治疗急性缺血性卒中得到食品与药物管理局(FDA)批准后,这项指南又补充了一系列的推荐[2].曲东锋 陈兴洲 李宏建 倪长江 Harold P.Adams Jr Robert J.Adams Thomas Brott Gregory J.del Zoppo Anthony Furlan Larry B.Goldstein Robert L.Grubb Randall Higashida Chelsea Kidwell Thomas G.Kwiatkowski John R.Marler George J.Hadermenos 2003国外医学(脑血管疾病分册)2003,11,5:57
6我国烟草及其制品中烟草特有亚硝胺含量及与前体物的关系显示文摘我国主要烟叶类型烟草特有亚硝胺(TSNA)水平排序为:白肋烟>沙姆逊香料烟>烤烟>巴斯马香料烟,其平均含量分别为10.25、0.89、0.25和0.03μg/g。在白肋烟和香料烟中,NNN和NAT为主要的TSNA,约占总TSNA的96%,且在总TSNA含量较高的烟样中,NNN占有较大比例。在烤烟中,NNN、NAT和NNK含量水平相差较小,且以NAT含量相对较高。我国烤烟型、混合型、雪茄型卷烟和雪茄的总TSNA含量平均分别为0.211、3.302、3.39和12.66μg/g。与国外样品相比,我国烤烟烟叶、烤烟型卷烟和混合型卷烟TSNA含量均显著低于国外水平。相关分析表明,烟叶和卷烟中的TSNA含量与降烟碱水平呈显著正相关,其中NNN与降烟碱相关性最大,相关系数达0.8633。史宏志 Lowell P.Bush 黄元炯 Jia Wang 刘国顺 王彦亭 赵明钦 于建军 Harold R.Burton 2002中国烟草学报2002,8,1:42
7烟草特有的N-亚硝胺形成、积累及其影响因素显示文摘烟草特有的N-亚硝胺(TSNA)是一组只在烟草、烟制品及烟气中发现的致癌物质。它们形成的前体物是烟草生物碱、硝酸盐和亚硝酸盐。大田正常生长及成熟的青烟不含TSNA,是采收后在调制、贮存陈化过程中逐步形成和积累起来的。凡影响前体物质的因素,都会影响烟草TSNA的形成、积累和含量。可通过控制两种前体物质的各种途径来降低烟草TSNA。杨焕文 李永忠 刘彦中 周平 崔明午 Lowell P.Bush Harold R.Burton 1998烟草科技1998,31,4:36
8Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields.Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas 2014World Journal of Gastroenterology2014,20,32:24
9SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 2013中国循证医学杂志2013,13,12:23
10成人缺血性卒中早期处理指南显示文摘本指南旨在对成年急性缺血性卒中患者评价和治疗各要素的现有证据做一回顾。目标读者是那些为发病后48h内的卒中患者提供治疗的内科医生和其他急诊医疗保健人员。另外,也包括向医疗保健政策制定者提供的信息。方法:专家小组成员由美国心脏协会(AHA)卒中委员会科学声明监督委员会任命,他们代表了来自不同领域的专家。专家小组以2003年后发表的报道为重点,对相关文献进行回顾,采用AHA卒中委员会的证据水平分级标准对证据进行分级并做出推荐。本声明经专家小组认可后,再由AHA科学顾问和协调委员会进行同行评议和正式批准。本指南打算在3年内做全面更新。结果:对急性缺血性卒中患者的处理仍然是多方面的,包括尚未在临床试验中进行过验证的一些医疗诊治方面。本声明包括从急诊医疗服务人员开始接触患者到入院初期处理的推荐意见。静脉重组组织型纤溶酶原激活剂仍然是已得到证实的最有效的卒中急诊治疗干预方法。包括动脉应用溶栓药和机械介入在内的一些方法显示出希望。因为许多推荐是在有限的证据基础上做出的,因此需要对急性缺血性卒中的治疗进行更多的研究。Harold P. Adams Gregory del Zoppo Mark J. Alberts Deepak L. Bhatt Lawrence Brass Anthony Furlan Robert L. Grubb Randall T. Higashida Edward C. Jauch Chelsea Kidwell Patrick D. Lyden Lewis B. Morgenstern Adnan I. Qureshi Robert H. Rosenwasser Phillip A. Scott Eelco F.M. Wijdicks 李焰生(译) 熊昕丽(译) 林岩(译) 沈沸(译) 俞羚(译) 邹静(译) 张静芳(译) 孙亚蒙(译) 周洁茹(译) 蒋仙国(译) 陈莺(译) 2007国际脑血管病杂志2007,15,6:18
11热处理对直链淀粉扩增、蜡性及正常玉米淀粉物理性质和酶解率的影响显示文摘对直链淀粉扩增(ae)、蜡性(wx)及正常玉米淀粉经热处理(autoclaving)后,其物理性质和酶解率的变化进行研究。淀粉经热处理后,除蜡性淀粉其峰值粘度增加外,所有淀粉的峰值粘度降低,且糊化温度提高。热处理增加扩增淀粉的热焓(ΔH),但降低蜡性淀粉的ΔH;同时对正常玉米淀粉的ΔH几乎无影响。热处理使蜡性和正常玉米淀粉的硬度和粘结力增加,但使扩增淀粉的硬度和粘结力降低;同时使所有淀粉的弹性降低。热处理后除蜡性淀粉其溶解率提高外,所有淀粉的膨胀率和溶解率降低。热处理降低所有淀粉的透光率和酶解率。刘惠君 Lawrence Ramsden Harold Corke 1998中国粮油学报1998,13,4:17
12急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南显示文摘背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版指南及其2009年更新版。方法著述委员会成员由美国卒中协会卒中委员会的科学声明监督委员会指定,代表各个领域的医疗专家。在形成共识的整个过程中,严格遵循美国心脏协会的利益冲突原则。委员会成员被分配给与其专业领域相关的内容,对卒中文献进行回顾,重点为前一版指南发表之后的文献,然后按照美国心脏协会卒中委员会的证据强度分级方案起草推荐意见。结果本指南的目的是减少卒中相关的残疾和死亡。本指南支持卒中医疗体系的全局性概念以及从患者识别、急救医疗服务激活、转送和分诊到急诊室和卒中单元内最初数小时诊治的卒中诊治细节。本指南讨论了早期卒中评估和一般治疗、缺血性卒中治疗、特殊干预措施,如再灌注策略以及脑复苏的一般生理学干预原则。结论由于许多推荐意见基于有限的证据,还迫切需要对急性缺血性卒中的治疗做进一步的研究。Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Jr, Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) 2013国际脑血管病杂志2013,21,7:17
13Numerical Analysis of Nozzle Clearance's Effect on Turbine Performance显示文摘Variable nozzle turbine (VNT) has become a popular variable geometry turbine (VGT) technology for the diesel engine application. Nozzle clearance, which can't be avoided on the hub and shroud side of the VNT turbine due to the pivoting stators, can lead to turbine performance deterioration. However, its mechanism is still not clear. In this paper, numerical investigation, which is validated by experiment, is carried out to study the mechanism of the nozzle clearance's effect on the turbine performance. Firstly, performance of the mixed flow turbine with fixed nozzle clearances tested on flow bench. Performance of the tested turbine with the same nozzle clearance is numerically simulated. The numerical result agrees well with the test data, which proves correct of the numerical method. Then the turbine performance with different nozzle clearances is numerically analyzed. The research showed that with nozzle clearance, flow loss in the nozzle increases at first and it reaches the maximum value when the clearance ratio is 5%. Flow at the exit of the nozzle becomes less uniform with nozzle clearance. The negative incidence angle of the rotor also increases with nozzle clearance and leads to more incidence angle loss in the rotor. The low energy fluid formed in the nozzle due to the nozzle clearance migrates from hub to shroud side in the rotor, which is another main reason for the rotor's performance degradation. The present research exposed the mechanism of the dramatically decrease of the turbine performance with nozzle clearance: (a) The loss associated with the nozzle leakage increases with the nozzle clearance; (b) The flow loss grows up quickly in the rotor due to the incidence angle loss and migration of the low energy fluid from hub to shroud side.HU Liangjun YANG Ce SUN Harold ZHANG Jizhong LAI Mingchia 2011Chinese Journal of Mechanical Engineering2011,24,4:17
14环糊精的发展与改性研究显示文摘1 环糊精的发展 淀粉科学是碳水化合物化学的重要组成部分,碳水化合物是指植物通过光合反应天然合成的一类有机化合物。淀粉属于碳水化合物,主要来源于谷物的种子中和薯类作物的根茎中。原淀粉来源丰富,是一种宝贵的工业原料,随着淀粉科学的发展及现代科学技术的进步,对原淀粉进行深加工已能制备出许多重要产品,如淀粉糖产品。李文德 周俊侠 张力田 Harold Corke 1996山西食品工业1996,,1:12
15这项临床试验完成注册了吗?——国际医学杂志编辑委员会声明显示文摘Catherine De Angelis Jeffrey M. Drazen Frank A. Frizelle Charlotte Haug John Hoey Richard Horton Sheldon Kotzin Christine Laine Ana Marusic A. John P.M. Overbeke Torben V.Schroeder Harold C. Sox Martin B. Van Der Weyden 刁骧(译) 孙丁(审校) 秦莉(审校) 2006中国循证医学杂志2006,6,4:11
16Elastic properties of chiral,anti-chiral,and hierarchical honeycombs:A simple energy-based approach显示文摘The effects of two geometric refinement strategies widespread in natural structures, chirality and self-similar hierarchy, on the in-plane elastic response of two-dimensional honeycombs were studied systematically. Simple closed-form expressions were derived for the elastic moduli of several chiral, antichiral, and hierarchical honeycombs with hexagon and square based networks. Finite element analysis was employed to validate the analytical estimates of the elastic moduli. The results were also compared with the numerical and experimental data available in the literature. We found that introducing a hierarchical refinement increases the Young's modulus of hexagon based honeycombs while decreases their shear modulus. For square based honeycombs, hierarchy increases the shear modulus while decreasing their Young's modulus. Introducing chirality was shown to always decrease the Young's modulus and Poisson's ratio of the structure. However, chirality remains the only route to auxeticity. In particular, we found that anti-tetra-chiral structures were capable of simultaneously exhibiting anisotropy, auxeticity,and remarkably low shear modulus as the magnitude of the chirality of the unit cell increases.Davood Mousanezhad Babak Haghpanah Ranajay Ghosh Abdel Magid Hamouda Harold Nayeb-Hashemi Ashkan Vaziri 2016Theoretical & Applied Mechanics Letters2016,6,2:11
17微小按蚊rDNA内转录间隔2区序列差异显示文摘目的 :比较不同地株微小按蚊核糖体DNA(rDNA)内转录间隔 2区 (ITS2 )序列差异。方法 :通过对PCR扩增rDNAITS2片段测序 ,比较其不同地株差异。结果 :对 6株微小按蚊测序比较 ,存在有微小按蚊A和C型。结论 :rDNAITS2序列差异可用于建立A。王学忠 Harold Townson 王丕玉 李菊升 2001中国媒介生物学及控制杂志2001,12,1:11
18利用一个水稻RIL群体定位控制淀粉特性的QTL(英文)显示文摘利用一个由籼粳(Oryza sativa L.)杂交发展成的重组自交系(RIL)群体研究影响淀粉特性的遗传因子,测定了一系列淀粉特性有关性状,包括直链淀粉含量、胶稠度、淀粉糊粘度、胶的质地、糊化温度、热学特性、回生特性等22个参数。共定位了44个QTL,分布在第2~6、8、9、11染色体上,每个性状所定位的QTL在1到4个不等。其中有2个是主基因,一个是第6染色体上的Wx基因,它控制直链淀粉含量、胶稠度、淀粉糊粘度、胶的质地、回生特性等性状,另一个是第6染色体上的alk基因,它控制糊化温度与热学特性等性状,其他QTL都是微效基因,在第9染色体上RZ404和G295区间系首次检测到,它控制淀粉胶的硬度(hardness)、胶粘性(gumminess)、咀嚼性(chewiness)、回生淀粉的最高糊化温度、回生率等性状,这些性状都未曾研究过。包劲松 Harold CORKE 何平 朱立煌 2003Acta Botanica Sinica2003,45,8:10
19Simultaneous biodegradation of nitrogen-containing aromatic compounds in a sequencing batch bioreactor显示文摘许多包含氮的芳香的混合物( NAC ),如此的 asnitrobenzene ( NB ), 4-nitrophenol ( 4-NP ),苯胺(一),并且2,4二硝基酚( 2,4-DNP ),从污染的水是 environmentallyhazardous ,和他们的移动主要挑战之一正在面对 wastewatertreatment plants.In 这研究,合成废水包含 NB ,从 50~180 mg/L 的 4-NP,2,4-DNP ,和 atconcentrations 被喂进定序批反应堆( SBR ) .Analyses ofthe SBR 系统显示它同时移开超过99%LIU Xing-yu WANG Bao-jun JIANG Cheng-ying ZHAO Ke-xin Harold L. Drake LIU Shuang-Jiang 2007Journal of Environmental Sciences2007,19,5:10
20Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis.Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira 2019Stroke & Vascular Neurology2019,4,4:10
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