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| 1 | 腔内修复破裂的腹主动脉瘤手术死亡率:一个系统评价和Meta分析显示文摘尽管现代外科取得了一些进展,但通过开放手术治疗破裂的腹主动脉瘤(ruptured abdominalaortic aneurysms,RAAAs)其死亡率仍高达50%左右。由于来到医院的患者存活率不到一半,由RAAAs所导致的死亡率更高,为80%-90%。最近,一个Meta分析对近50年的RAAAs修复进行了总结, | Karkos CD Harkin DW Giannakou A 刘军麟 殷梅 | 2010 | 中华普通外科学文献(电子版)2010，4，2： | 5 |
| 2 | Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease显示文摘Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson's disease(PD), whereas pharmacological approaches to increase noradrenaline bioavailability may provide neuroprotection. Noradrenaline inhibits microglial activation and suppresses pro-inflammatory mediator production(e.g., tumor necrosis factor-α, interleukin-1β & inducible nitric oxide synthase activity), thus limiting the cytotoxicity of midbrain dopaminergic neurons in response to an inflammatory stimulus. Neighbouring astrocyte populations promote a neurotrophic environment in response to β_2-adrenoceptor(β_2-AR) stimulation via the production of growth factors(e.g., brain derived neurotrophic factor, cerebral dopamine neurotrophic factor & glial cell derived neurotrophic factor which have shown promising neuroprotective and neuro-restorative effects in the nigrostriatal dopaminergic system. More recent findings have demonstrated a role for the β_2-AR in down-regulating expression levels of the human α-synuclein gene SNCA and relative α-synuclein protein abundance. Given that α-synuclein is a major protein constituent of Lewy body pathology, a hallmark neuropathological feature in Parkinson's disease, these findings could open up new avenues for pharmacological intervention strategies aimed at alleviating the burden of α-synucleinopathies in the Parkinsonian brain. In essence, the literature reviewed herein supports our hypothesis of a tripartite neuroprotective role for noradrenaline in combating PD-related neuropathology and motor dysfunction via(1) inhibiting nigral microglial activation & pro-inflammatory mediator production,(2) promoting the synthesis of neurotrophic factors from midbrain astrocytes and(3) downregulating α-synuclein gene expression and protein abundance in a β_2-AR-dependent manner. Thus, taken together, either pharmacologically enhancing extra-synaptic noradrenaline bioavailability or targeting glial β_2-ARs directly makes itself as a promising treatment option aimed at slowing/halting PD progression. | Eoin O'Neill Andrew Harkin | 2018 | Neural Regeneration Research2018，13，8： | 5 |
| 3 | Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction 显示文摘 | Yassin M M Harkin D W Barros D'Sa A A | 2002 | World JSurg2002，26，1： | 1 |
| 4 | Rapid flow cytometric analysisof the cell cycle in intact plant tissues显示文摘 | GALBRAITH D W HARKINS K R MADDOX J M AYRES N M SHARMA D P FIROOZABADY E | 1983 | Science1983，220，4601： | 1 |
| 5 | An endotracheal metallic prosthesis in the treatment of stenosis of the upper trachea 显示文摘 | Harkins WB | 1952 | Ann Otol Rhinol Laryngol1952，61，： | 1 |
| 6 | Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine显示文摘 | An LL Rodriguez F Harkins S | 2000 | Vaccine2000，18，20： | 1 |
| 7 | The determination of surface tension and the weight of falling drops:the surface tension of water and benzene by the capillary height method显示文摘 | Harkins W D Brown F E | 1919 | J Am Chem Soc1919，41，4： | 1 |
| 8 | Airways and lung:correlation of CT with fi-beroptic bronchoscopy显示文摘 | Naidich DP Harkin TJ | 1995 | Radiology1995，197，1： | 1 |
| 9 | Technique for internal fixationof capitellum and lateral trochlea fractures 显示文摘 | Mighell MA Harkins D Klein D | 2006 | J Orthop Trauma2006，10，： | 1 |
| 10 | Rapid fluvial incision along the Yellow River during headward basin integration 显示文摘 | CRADDOCK W H KIRBY E HARKINS N W | 2010 | Nature Geoscience2010，3，3： | 1 |
| 11 | Runup of solitary waves on a circular island显示文摘 | Briggs M J Synolakis C E Harkins G S | 1995 | Fluid Mechanics1995，302，： | 1 |
| 12 | Cardiovascular responses to sevoflurane : a review 显示文摘 | Ebert TJ Harkin CP Muzi M | 1995 | Anesth Analg1995，81，6： | 1 |
| 13 | Osteopontin expression in normal skin and non-melanoma skin tumors 显示文摘 | Chang PL Harkins L Hsieh YH | 2008 | J Histochem Cytochem2008，56，1： | 1 |
| 14 | Human cytomegalovirus infection and expression in human malignant gliomal显示文摘 | Cobbs CS Harkins L Samanta G | 2002 | Cancer Res2002，62，12： | 1 |
| 15 | Client-server architecture for collaborative remote experiment显示文摘 | Callaghan M J Harkin J McColgan E | | 0，，04： | 1 |
| 16 | Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer显示文摘 | Harkins L Volk AL Samanta M | | 0，，9345： | 1 |
| 17 | Challenges for large-scale implementations of spiking neural networks on FPGAs显示文摘 | Maguire LP McGinnity TM Glackin B Ghani A Belatreche A Harkin J | | 0，，1： | 1 |
| 18 | The cal-cemic response to continuous parathyroid hormone (PTH)(1-34) infusion in end-stage kidney disease varies ac-cording to bone turnover: a potential role for PTH(7-84) 显示文摘 | Wesseling-Perry K Harkins GC Wang HJ | 2010 | J Clin Endocrinol Metab2010，95，6： | 1 |
| 19 | Quantifying biofilm structure: facts and fiction 显示文摘 | BEYENAL H LEWANDOWSKI Z HARKIN G | 2004 | Biofouling2004，20，1： | 1 |
| 20 | 5-Fluorouracil:mechanisms of action and clinical strategies显示文摘 | Daniel B Bonglev D Paul Harkin Patrick G Johnston | 2003 | Nature Review Cancer2003，5，： | 1 |
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