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| 1 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | Treatment options for baeterial vaginosis in patients at igh risk of preterrn labor and premature rupture of membranes 显示文摘 | Darwish A Elnshar EM Hamadeh SM | 2007 | Journal of Obstetrics and Gynaecology Reseach2007，33，6： | 1 |
| 3 | Automated 3- dimensional computed tomographic and fluoroscopic image registration 显示文摘 | HAMADEH A LAVALLEE S CINQUIN P | 1998 | Comput Aided Surg1998，3，1： | 1 |
| 4 | Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital显示文摘 | Ueda A Hamadeh HK Webb HK | 2002 | Mol Pharmacol2002，61，1： | 1 |
| 5 | The evolution of bioinformatics in toxicology:Advancing toxicogenomics显示文摘 | Afshari C A Hamadeh H K Bushel P R | | 0，，1： | 1 |
| 6 | Treatment options for bacterial vaginosis in patients at high risk of preterm labor and premature rupture of membranes显示文摘 | Darwish A Elnshar EM Hamadeh SM | 2007 | J Obstet Gynaecol Res2007，33，6： | 1 |
| 7 | Diverse roles of the nu- clear orphan receptor CAR in regulating hepatic genesin response to phenobarbital显示文摘 | Ueda A Hamadeh HK Webb HK | 2002 | Mol Pharmacol2002，61，： | 1 |
| 8 | Treatment optionsfor bacterial vaginosis in patients at high risk of preterm labor andpremature rupture of membranes 显示文摘 | Darwish A Elnshar EM Hamadeh SM | 2007 | J Obstetr & Gynaecol Res2007，33，6： | 1 |
| 9 | Comparative assessment of man- aged aquifer recharge versus constructed wetlands in managing chemical and microbial risks during wastewater reuse : a review 显示文摘 | A F Hamadeh S K Sharma G Amy | 2014 | Journal of Water Reuse & Desalination2014，4，1： | 1 |
| 10 | Aberrant mitochondrial homeostasis in the skeletal muscle of sed- entary older adults显示文摘 | Safdar A Hamadeh M J Kaczor J J | 2010 | PLoS One2010，5，10： | 1 |
| 11 | Diverse roles of the nuclear orphan receptol' CAR in regulating hepatic genes in response to phenobarbital 显示文摘 | Ueda A Hamadeh HK Webb HK | 2002 | Mol Pharmacol2002，61，1： | 1 |
| 12 | Aspartate Amin- otransferase Enzyme Activity in Gingival Crevicular Fluid is affected by Human Orthodontic Tooth Movement 显示文摘 | Dannan A Alkattan F Hamadeh S et aI | 2003 | Jour- nal of Periodontology2003，74，2： | 1 |
| 13 | Nutri- tional attributes of traditional flaxseed in healthy young adults 显示文摘 | CUNNANE S C HAMADEH M J LIEDE A C | 1994 | Am J Clin Nutr1994，61，1： | 1 |
| 14 | The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men显示文摘 | Samioo IA Safdar A Hamadeh M J | 2013 | Nutr Diabetes2013，3，： | 1 |
| 15 | Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital 显示文摘 | Ueda A Hamadeh HK Webb HK | 2002 | Mol Pharmacol2002，61，1： | 1 |
| 16 | Comparison of the Epstein frame and single strip tester for measuring the power loss of non-oriented electrical steels显示文摘 | Moses A J Hamadeh S | 1983 | IEEE Transac- tions on Magnetics1983，19，6： | 1 |
| 17 | Cardiac arrest secondary to bilateral pulmonary emboli following arteriovenous fistula thrombectomy: a case report with review of the literature显示文摘 | Shah A Ansari N Hamadeh Z | 2012 | Case Reports in Nephrology2012，2012，83： | 1 |
| 18 | Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces 显示文摘 | Hamadeh R M Jarvis G A Galili U | 1992 | J Clin Invest1992，89，4： | 1 |
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