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| 1 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | Age and sex are important factors in determing normal retinol levels 显示文摘 | Lindblad BS Patel M Hamadeh M | 1998 | j Trop Pediatr1998，44，： | 1 |
| 3 | Arsenic binding proteins from human lymphoblastoid cells显示文摘 | MENZEL D B HAMADEH H K LEE E | 1999 | Toxicol Lett1999，105，2： | 1 |
| 4 | Evaluation of enrofloxacin treatment program against Mycoplasma gaIlisepticum infection in broilers显示文摘 | Barbour EK Hamadeh S Talhouk R | 1998 | Prey Vet Med1998，35，2： | 1 |
| 5 | Arsenic disrupts cellular levels of p53 and mdm2 : a potential mechanism of carcinogenesis 显示文摘 | Hamadeh HK Vargas M Lee E | 1999 | Bioehem Biophys Res Commun1999，263，2： | 1 |
| 6 | Evaluation of enroflox- acin treatment program against Mycoplasma galliseticum infection in broil- ers显示文摘 | BARBOUR E K HAMADEH S TALHOUK R | 1998 | Prenentive Vet Med1998，35，2： | 1 |
| 7 | Treatment options for baeterial vaginosis in patients at igh risk of preterrn labor and premature rupture of membranes 显示文摘 | Darwish A Elnshar EM Hamadeh SM | 2007 | Journal of Obstetrics and Gynaecology Reseach2007，33，6： | 1 |
| 8 | Arsenic disrupts cellular levels of p53and mdm2:a potential mechanism of carcinogenesis显示文摘 | Hamadeh HK Vargas M Lee E | 1999 | Biochem Biophys Res Commun1999，263，2： | 1 |
| 9 | Automated 3- dimensional computed tomographic and fluoroscopic image registration 显示文摘 | HAMADEH A LAVALLEE S CINQUIN P | 1998 | Comput Aided Surg1998，3，1： | 1 |
| 10 | Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital显示文摘 | Ueda A Hamadeh HK Webb HK | 2002 | Mol Pharmacol2002，61，1： | 1 |
| 11 | Evaluation of enrofloxacin treatment program against Mycoplasma galliseticum infection in broilers显示文摘 | Barbour E K Hamadeh S Talhouk R | 1998 | Preventive Vet Med1998，35，2： | 1 |
| 12 | Arsenic binding proteins from human lymphoblastoid cells显示文摘 | Menzel D B Hamadeh H K Lee E | 1999 | Toxicology Letters1999，105，2： | 1 |
| 13 | 显示文摘 | Hamadeh HK | 2001 | Biochem Mol Toxicol2001，15，： | 1 |
| 14 | Menstrual cycle phase and sex influence muscle glycogen utilization and glucose turnover during moderate-intensity endurance exercise显示文摘 | Devries M C Hamadeh M J Phillips S M | 2006 | Am J Physiol Regul Integr Comp Physiol2006，291，4： | 1 |
| 15 | Evaluation of a- nenrofloxacin treatment program against Mycoplasmagalliseptic- urn infection in broilers显示文摘 | Barbour EK Hamadeh S Talhouk B | 1998 | Preventive Vet Med1998，35，2： | 1 |
| 16 | Sulfate could mediate the therapeutic effect of glucosamine sulfate显示文摘 | HOFFER L J KAPLAN L N HAMADEH M J | 2001 | Metabolism2001，50，7： | 1 |
| 17 | Age and sex important faclors in determining normal retinol levels显示文摘 | Lindblad BS Pale M Hamadeh M | 1998 | Trop Pediaric1998，44，2： | 1 |
| 18 | 显示文摘 | Hamadeh HK | 2002 | Toxicol Sci2002，67，： | 1 |
| 19 | Gene expres- sion analysis reveals chemical-specific profiles显示文摘 | Hamadeh H K Bushel P R Jayadev S | 2002 | Toxi- col Sci2002，67，： | 1 |
| 20 | Common prescriptions in ambulatory eare in Lebanon显示文摘 | Hamadeh GN Dickerson LM Saab BR | 2001 | Ann Pharmacother2001，35，： | 1 |
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