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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 3 | Genotyping and pathotyping of diversified strains of infectious bronchitis viruses circulating in Egypt显示文摘AIM: To characterize the circulating infectious bronchitis virus(IBV) strains in Egypt depending on the sequence of the spike-1(S1) gene [hypervariable region-3(HVR-3)] and to study the pathotypic features of these strains.METHODS: In this work, twenty flocks were sampled for IBV detection using RRT-PCR and isolation of IBV in specific pathogen free(SPF) chicks during the period from 2010 to 2015. Partial sequencing and phylogenetic analysis of 400 bp representing the HVR-3 of the S1 gene was conducted. Pathotypic characterization of one selected virus from each group(Egy/Var-Ⅰ, Egy/Var-Ⅱ and classic) was evaluated in one day old SPF chicks. The chicks were divided into 4 groups 10 birds each including the negative control group. Birds were inoculated at one day by intranasal instillation of 105EID50/100 μL of IBV viruses [IBV-EG/1212B-2012(Egy/Var-Ⅱ), IBV/EG/IBV1-2011(Egy/Var-Ⅰ) and IBV-EG/11539F-2011(classic)], while the remaining negative control group was kept uninfected. The birds were observed for clinical signs, gross lesions and virus pathogenicity. The real-time rR TPCR test was performed for virus detection in the tissues. Histopathological examinations were evaluated in both trachea and kidneys.RESULTS: The results revealed that these viruses were separated into two distinct groups; variant(GI-23) and classic(GI-1), where 16 viruses belonged to a variant group, including 2 subdivisions [Egy/Var-Ⅰ(6 isolates) and Egy/Var-Ⅱ(10 isolates)] and 4 viruses clustered to the classic group(Mass-like). IBV isolates in the variant group were grouped with other IBV strains from the Middle East. The variant subgroup(Egy/Var-Ⅰ) was likely resembling the original Egyptian variant strain(Egypt/Beni-Suif/01) and the Israeli strain(IS/1494/2006). The second subgroup(Egy/Var-Ⅱ) included the viruses circulating in the Middle East(Ck/EG/BSU-2 and Ck/EG/BSU-3/2011) and the Israeli strain(IS/885/00). The two variant subgroups(Egy/Var-Ⅰ and Egy/Var-Ⅱ) found to be highly pathogenic to SPF chicks with mortalities up to 50% than those of the classic group which was of low virulence(10% mortality). Pathogenicity indices were 25(Egy/Var-Ⅱ), 24(Egy/Var-Ⅰ) and 8(classic); with clinical scores 3, 2 and 1 respectively.CONCLUSION: These findings indicated that the recent circulating Egyptian IBVs have multiple heterogeneous origins in marked diversifying nature of their spread, with high pathotype in specific pathogen free chicks. | Ali Zanaty Abdel-Satar Arafa Naglaa Hagag Magdy El-Kady | 2016 | World Journal of Virology2016，5，3： | 3 |
| 4 | Effects of Nigella sativa on outcome of hepatitis C in Egypt显示文摘AIM: To evaluate the safety, efficacy and tolerability of Nigella sativa (N. sativa ) in patients with hepatitis C not eligible for interferon (IFN)-α. METHODS: Thirty patients with hepatitis C virus (HCV) infection, who were not eligible for IFN/ribavirin therapy, were included in the present study. Inclusion criteria included: patients with HCV with or without cirrhosis, who had a contraindication to IFN-α therapy, or had refused or had a financial constraint to IFN-α therapy. Exclusion criteria included: patients on IFN-α therapy, infection with hepatitis B or hepatitis Ⅰ virus, hepatocellular carcinoma, other malignancies, major severe illness, or treatment non-compliance. Various parameters, including clinical parameters, complete blood count, liver function, renal function, plasma glucose, total antioxidant capacity (TAC), and polymerase chain reaction, were all assessed at baseline and at the end of the study. Clinical assessment included: hepato and/ or splenomegaly, jaundice, palmar erythema, flapping tremors, spider naevi, lower-limb edema, and ascites. N. sativa was administered for three successive months at a dose of (450 mg three times daily). Clinical response and incidence of adverse drug reactions were assessed initially, periodically, and at the end of the study. RESULTS: N. sativa administration significantly improved HCV viral load (380808.7 ± 610937 vs 147028.2 ± 475225.6, P = 0.001) and TAC (1.35 ± 0.5 vs 1.612 ± 0.56, P = 0.001). After N. sativa administration, the following laboratory parameters improved: total protein (7.1 ± 0.7 vs 7.5 ± 0.8, P = 0.001), albumin (3.5 ± 0.87 vs 3.69 ± 0.91, P = 0.008), red blood cell count (4.13 ± 0.9 vs 4.3 ± 0.9, P = 0.001), and platelet count (167.7 ± 91.2 vs 198.5 ± 103, P = 0.004). Fasting blood glucose (104.03 ± 43.42 vs 92.1 ± 31.34, P = 0.001) and postprandial blood glucose (143.67 ± 72.56 vs 112.1 ± 42.9, P = 0.001) were significantly decreased in both diabetic and non-diabetic HCV patients. Patients with lower-limb edema decreased significantly from baseline compared with after treatment [16 (53.30%) vs 7 (23.30%), P = 0.004]. Adverse drug reactions were unremarkable except for a few cases of epigastric pain and hypoglycemia that did not affect patient compliance. CONCLUSION: N. sativa administration in patients with HCV was tolerable, safe, decreased viral load, and improved oxidative stress, clinical condition and glycemic control in diabetic patients. | Eman Mahmoud Fathy Barakat Lamia Mohamed El Wakeel Radwa Samir Hagag | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 5 | A study of the clinical differences between women and men with hyper-prolactinemia显示文摘 | RAPOPORT M J HAGAG P | 1996 | Gynecol Endocrinol1996，10，6： | 1 |
| 6 | Role of ultrasound - guidedfine - needle aspiration biopsy in evaluation of nonpalpable thyroidnodules显示文摘 | HAGAG P STRAUSS S WEISS M | 1998 | Thyroid1998，8，11： | 1 |
| 7 | Subtotal and near total ver-sus total thyroidectomy for the management of multi nodular goi-ter显示文摘 | Vaiman M Nagibin A Hagag P | 2008 | World J Surg2008，32，7： | 1 |
| 8 | Nonlinear modelling and vibration control of jib cranes 显示文摘 | Yazied T G Hagag S Y Ajmi M S | 2012 | World Applied Sciences Journal2012，16，11： | 1 |
| 9 | Microinjection of ras p21 induces a rapid rise in intracellular pH显示文摘 | HAGAG N LACAL J C GRABER M | | 0，，05： | 1 |
| 10 | Subtotal and near total versus total thyroideetomy for the management of multinodular goiter显示文摘 | Vaiman M Nagibin A Hagag P | 2008 | World J Surg2008，32，7： | 1 |
| 11 | Early postmenopausal bone loss in hyperthyroidism 显示文摘 | Ben - Shlomo A Hagag P Evans S | 2001 | Maturitas2001，39，1： | 1 |
| 12 | Subtotal and near total ver- sus total spleen deetomy 显示文摘 | Vaiman M Nagibin A Hagag P | 2008 | World J Surg2008，32，7： | 1 |
| 13 | Coagulant component in Cerastes cerastes (Egyptian sand viper) venom显示文摘 | 34 el-Asmar MF Shaban E Hagag M | 1986 | Toxicon1986，24，： | 1 |
| 14 | Nonlinear modelling and vibration control of jib cranes 显示文摘 | Yazied T G Hagag S Y Ajmi M S | 2012 | World Applied Sciences Journal2012，16，11： | 1 |
| 15 | Cloning regions of the Drosophila genome by microdissection of polytene chromosome DNA and PCR with nonspecific primer 显示文摘 | Wesley CS Ben M Kreitman M Hagag N Eanes WF | 1990 | Nucleic Acids' Res1990，18，3： | 1 |
| 16 | Prognostic value of plasma pro-adrenomedullin and antithrombin levels in neonatal sepsis显示文摘 | Hagag AA Elmahdy HS Ezzat AA | 2011 | Indian Pediatr2011，48，6： | 1 |
| 17 | Subtotal and near total versus total thyroidectomy for the management of multi- nodular goiter 显示文摘 | Vaiman M Nagibin A Hagag P etal | 2008 | World J Surg2008，32，7： | 1 |
| 18 | Early postmenopausal bone loss in hyperthyroidism显示文摘 | Ben-Shlomo A Hagag P Evans S | 2001 | Maturities2001，39，： | 1 |
| 19 | Subtotal and near to-tal versus total thyroidectomy for the management of multi-nodular goiter显示文摘 | Vaiman M Nagibin A Hagag P | 2008 | World J Surg2008，32，7： | 1 |
| 20 | Follicular variant of papillary thyroid carcinoma: clinical-pathological characterization and long- term follow-up显示文摘 | Hagag P Hod N Kummer E | 2006 | Cancer J2006，12，4： | 1 |
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