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| 1 | Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development. | Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel | 2019 | High Power Laser Science and Engineering2019，7，3： | 33 |
| 2 | Experimental treatment of pancreatic cancer with two novel histone deacetylase inhibitors显示文摘AIM:To investigate in vitro and in vivo treatment with histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589 in pancreatic cancer. METHODS:Cell-growth inhibition by NVP-LAQ824 and NVP-LBH589 was studied in vitro in 8 human pancreatic cancer cell lines using the 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide(MTT) assay. In addition,the anti-tumoral effect of NVP-LBH589 was studied in a chimeric mouse model. Anti-tumoral activity of the drugs was assessed by immunoblotting for p21WAF-1,acH4,cell cycle analysis,TUNEL assay,and immunohistochemistry for MIB-1. RESULTS:In vitro treatment with both compounds significantly suppressed the growth of all cancer cell lines and was associated with hyperacetylation of nucleosomal histone H4,increased expression of p21WAF-1,cell cycle arrest at G2/M-checkpoint,and increased apoptosis. In vivo,NVP-LBH589 alone significantly reduced tumor mass and potentiated the efficacy of gemcitabine. Further analysis of the tumor specimens revealed slightly increased apoptosis and no significant reduction of cell proliferation.CONCLUSION:Our findings suggest that NVP-LBH589 and NVP-LAQ824 are active against human pancreatic cancer,although the precise mechanism of in vivo drug action is not yet completely understood. Therefore,further preclinical and clinical studies for the treatment of pancreatic cancer are recommended. | Martin Haefner Thilo Bluethner Manuel Niederhagen Christian Moebius Christian Wittekind Joachim Mossner Karel Caca Marcus Wiedmann | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 3 | Vulvar lichen sclerosus pathophysiology and treatment显示文摘 | Smith YR Haefner HK | 2004 | Am J Clin Dermatol2004，5，2： | 1 |
| 4 | Impact of multiresistance of gram-negative bacteria in bloodstream infection on mortality rates and length of stay显示文摘 | Sostarieh AM Zolldann D Haefner H | 2008 | Infection2008，36，1： | 1 |
| 5 | Evaluation of postdischarge surveillance of surgical site infection After total hip and knee arthroplasty显示文摘 | Huenger F Schmachteenberg A Haefner H etal | 2005 | Am J Infect Control2005，33，8： | 1 |
| 6 | Two metaphors of the niche 显示文摘 | Haefner J W | 1980 | Syn- these1980，43，1： | 1 |
| 7 | Vulvar lichen sclerosus : pathophysiology and treatment 显示文摘 | Smith YR Haefner HK | 2004 | Am J Clin Dermatol2004，5，2： | 1 |
| 8 | Bcl-2-mediated regulation of CD69-induced apoptosis ofhuman eosinophils : identification and characterizationof a novel receptor-induced mechanism andrelationship to CD95-transduced signaling 显示文摘 | FOEHSTEH M HAEFNER D KROEGEL C | 2002 | ScandJ Immunol2002，56，4： | 1 |
| 9 | Circular grating waveguide structures for intracavity generation of azimuthal polariza- tion in a thin-disk laser 显示文摘 | RUMPEL M HAEFNER M SCHODER T | 2012 | Optics Letters2012，37，10： | 1 |
| 10 | Biotechnological production and applications of phytases显示文摘 | Haefner S Knietsch A Scholten E | 2005 | Appl Microbiol Biotechnol2005，68，5： | 1 |
| 11 | Targeting NF-kappa B in anticancer adjunctive chemotherapy显示文摘 | Haefner B | | 0，，： | 1 |
| 12 | Biotechnological production and applications of phytases显示文摘 | HAEFNER S KNIETSCH A SCHOLTEN E | 2005 | Appl Microbiol Biotechnol2005，68，5： | 1 |
| 13 | A critique of methods for analysis of the diameter-frequency relation for craters with special application to the Moon显示文摘 | Chapman C R Haefner R R | 1967 | Journal of Geophysical Research1967，72，2： | 1 |
| 14 | Technique of Laparoscopic-Endoscopic Single-Site Surgery Radical Nephrectomy显示文摘 | Jens-Uwe Stolzenburg Panagiotis Kallidonis Giles Hellawell Minh Do Tim Haefner Anja Dietel Evangelos N. Liatsikos | 2009 | European Urology2009，，4： | 1 |
| 15 | Drugs from the deep;marine natural products as drug candidates显示文摘 | Haefner B | 2003 | DDT2003，8，12： | 1 |
| 16 | Compliance with hand hygiene in patients with meticillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase-producing enterobacteria显示文摘 | Scheithauer S Oberr?hrmann A Haefner H | | 0，，04： | 1 |
| 17 | Drugs from the deep:marine natural products as drug candidates 显示文摘 | Haefner B | 2003 | DDT2003，8，12： | 1 |
| 18 | Adaptation to natural binocular disparities in primate V1 explained by a generalized energy model显示文摘 | Haefner R M Cumming B G | 2008 | Neuron2008，57，1： | 1 |
| 19 | Vulvar intraepithelial neoplasia:age,morphological phenotype,papillomavirus DNA and coexisting invasive carcinoma显示文摘 | Haefner HK Tate JE McLachlin CM | 1995 | Hum Pathol1995，26，2： | 1 |
| 20 | Physical-based model of fish movement in fish extraction facilities 显示文摘 | Bowen M D | 2002 | Ecol Mod2002，152，： | 1 |
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