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| 1 | Liver surgery in cirrhosis and portal hypertension显示文摘The prevalence of hepatic cirrhosis in Europe and the United States, currently 250 patients per 100000 inhabitants, is steadily increasing. Thus, we observe a significant increase in patients with cirrhosis and portal hypertension needing liver resections for primary ormetastatic lesions. However, extended liver resections in patients with underlying hepatic cirrhosis and portal hypertension still represent a medical challenge in regard to perioperative morbidity, surgical management and postoperative outcome. The Barcelona Clinic Liver Cancer classification recommends to restrict curative liver resections for hepatocellular carcinoma in cirrhotic patients to early tumor stages in patients with Child A cirrhosis not showing portal hypertension. However, during the last two decades, relevant improvements in preoperative diagnostic, perioperative hepatologic and intensive care management as well as in surgical techniques during hepatic resections have rendered even extended liver resections in higher-degree cirrhotic patients with portal hypertension possible. However, there are few standard indications for hepatic resections in cirrhotic patients and risk stratifications have to be performed in an interdisciplinary setting for each individual patient. We here review the indications, the preoperative risk-stratifications, the morbidity and the mortality of extended resections for primary and metastatic lesions in cirrhotic livers. Furthermore, we provide a review of literature on perioperative management in cirrhotic patients needing extrahepatic abdominal surgery and an overview of surgical options in the treatment of hepatic cirrhosis. | Christina Hackl Hans J Schlitt Philipp Renner Sven A Lang | 2016 | World Journal of Gastroenterology2016，22，9： | 21 |
| 2 | Split liver transplantation: Current developments显示文摘In 1988, Rudolf Pichlmayr pioneered split liver transplantation(SLT), enabling the transplantation of one donor liver into two recipients-one pediatric and one adult patient. In the same year, Henri Bismuth and colleagues performed the first full right/full left split procedure with two adult recipients. Both splitting techniques were rapidly adopted within the transplant community. However, a SLT is technically demanding, may cause increased perioperative complications, and may potentially transform an excellent deceased donor organ into two marginal quality grafts. Thus, crucial evaluation of donor organs suitable for splitting and careful screening of potential SLT recipients is warranted. Furthermore, the logistic background of the splitting procedure as well as the organ allocation policy must be adapted to further increase the number and the safety of SLT. Under defined circumstances, in selected patients and at experienced transplant centers, SLT outcomes can be similar to those obtained in full organ LT. Thus, SLT is an important tool to reduce the donor organ shortage and waitlist mortality, especially for pediatric patients and small adults. The present review gives an overview of technical aspects, current developments, and clinical outcomes of SLT. | Christina Hackl Katharina M Schmidt Caner Süsal Bernd Dohler Martin Zidek Hans J Schlitt | 2018 | World Journal of Gastroenterology2018，24，47： | 20 |
| 3 | Current developments in pediatric liver transplantation显示文摘In 1953, the pioneer of human orthotopic liver transplantation(LT), Thomas E Starzl, was the first to attempt an orthotopic liver transplant into a 3 years old patient suffering from biliary atresia. Thus, the first LT in humans was attempted in a disease, which, up until today, remains the main indication for pediatric LT(p LT). During the last sixty years, refinements in diagnostics and surgical technique, the introduction of new immunosuppressive medications and improvements in perioperative pediatric care have established LT as routine procedure for childhood acute and chronic liver failure as well as inherited liver diseases. In contrast to adult recipients, p LT differs greatly in indications for LT, allocation practice, surgical technique, immunosuppression and postoperative life-long aftercare. Many aspects are focus of ongoing preclinical and clinical research. The present review gives an overview of current developments and the clinical outcome of p LT, with a focus on alternatives to full-size deceased-donor organ transplantation. | Christina Hackl Hans J Schlitt Martin Loss Birgit Knoppke Michael Melter | 2015 | World Journal of Hepatology2015，7，11： | 13 |
| 4 | Liver transplantation for malignancy:current treatment strategies and future perspectives显示文摘In 1967,Starzl et al performed the first successful liver transplantation for a patient diagnosed with hepatoblastoma.In the following,liver transplantation was considered ideal for complete tumor resection and potential cure from primary hepatic malignancies.Several reports of liver transplantation for primary and metastatic liver cancer however showed disappointing results and the strategy was soon dismissed.In1996,Mazzaferro et al introduced the Milan criteria,offering liver transplantation to patients diagnosed with limited hepatocellular carcinoma.Since then,liver transplantation for malignant disease is an ongoing subject of preclinical and clinical research.In this context,several aspects must be considered:(1)Given the shortage of deceased-donor organs,long-term overall and disease free survival should be comparable with results obtained in patients transplanted for nonmalignant disease;(2)In this regard,living-donor liver transplantation may in selected patients help to solve the ethical dilemma of optimal individual patient treatment vs organ allocation justice;and(3)Ongoing research focusing on perioperative therapy and antiproliferative immunosuppressive regimens may further reduce tumor recurrence in patients transplanted for malignant disease and thus improve overall survival.The present review gives an overview of current indications and future perspectives of liver transplantation for malignant disease. | Christina Hackl Hans J Schlitt Gabriele I Kirchner Birgit Knoppke Martin Loss | 2014 | World Journal of Gastroenterology2014，20，18： | 7 |
| 5 | Simulation of Mould Level Velocities During Continuous Casting of Round Bloom Strands With Mould-Electromagnetic Stirring显示文摘In modern continuous casting of round steel blooms rotating electromagnetic fields are commonly employed to improve the product quality.Mould-electromagnetic stirrers(M-EMS)are used to excite a rotary motion along the solidification front in the liquid core.These velocities lead to a better strand surface quality as well as enhancing the transition from columnar to equiaxed solidification.Although the usage of electromagnetic stirrers is widespread,not all effects are fully known or understood.Due to harsh conditions at the plant,measurements are scarce and limited.Water model experiments-an established alternative for investigating continuous casting of steel-cannot be used due to the low electrical conductivity of water.Experiments with liquid metals like mercury,Galinstan or Wood's metal are either expensive or difficult to perform.Thus numeric simulations are essential to gain a better understanding of the processes involved in continuous casting with electromagnetic stirring.However numeric simulations should always be validated with experiments and/or measurements.While the velocity field inside the liquid core of the bloom cannot be measured at the caster,the velocity at the mould level can be measured by dipping a nail into it.The skull forming at the tip of the nail is directly linked to the occurring surface velocity.These measurements can then be compared with numeric simulations of the nail dipping process.The numeric model is restricted to the upper part of the strand.The lower part of the strand is also taken into account through adjusted boundary conditions(velocity field etc.taken from a simulation of the whole strand).In this work the influence of the stirring field strength on the simulation results will be investigated.In the future these nail dipping simulations will be validated with plant measurements.This can then to a certain extentvalidate the simulation of the strand with M-EMS too,as it serves as the basis for the nail dipping model. | BARNAMartin JAVUREK Mirko REITER Jurgen WATZINGER Josef KAUFMANN Bernhard HACKL Gemot | 2012 | Journal of Iron and Steel Research(International)2012，19，S2： | 3 |
| 6 | Interfacial microstructure and mechanical properties of aluminium–zinc-coated steel joints made by a modified metal inert gas welding–brazing process显示文摘 | H.T. Zhang J.C. Feng P. He H. Hackl | 2006 | Materials Characterization2006，，7： | 2 |
| 7 | Survival in patients undergoing transjugular intrahepatic portosystemic shunt: ePTFE-covered stentgrafts versus bare stents显示文摘 | Bernhard Angermayr Manfred Cejna Franz Koenig Franz Karnel Franz Hackl Alfred Gangl Markus Peck-Radosavljevic | 2003 | Hepatology2003，，4： | 2 |
| 8 | 高速连铸用新型浸入式水口显示文摘连铸机结晶器内钢液的流动状态严重影响连铸坯的质量,尤其在弯月面处,钢液与结晶器保护渣直接接触,结晶器内弯月面不稳定引起的卷渣,是导致产品产生缺陷的主要原因之一,如冷轧薄板的线状缺陷和厚板的表面缺陷。在结晶器润滑不均匀时,还会增加漏钢危险。弯月面液面波动主要是由于浸入式水口吐出孔钢液剧烈的湍流和瞬态行为引起的。最近,在一台连铸机上浇注不同钢种已成为全世界钢铁生产商努力的一个主要方向。为了满足所有钢种的质量要求,对每个钢种都要求一定的浇注速度。对常规的浸入式水口而言,确保结晶器内有利的流动条件是一个难题。因此,比以往更需要一种新型浸入式水口,通过保持最佳的结晶器内钢液流动状态,以各种浇注速度浇注出多规格铸坯。介绍了测试新型浸入式水口流动性能的数值模型和物理模型的试验。采用URANS方法瞬态CFD模拟表明,新型浸入式水口流出的钢液瞬态行为稳定,因而弯月面以下钢液流速较慢,其效果还通过水模拟得到了验证。现场试验是在中国台湾的中钢公司进行的,试验结果表明,通过优化结晶器内钢液的流动行为,结晶器液面波动明显减小,从而提高了产品质量。 | Shung Sheng Kao Hsin Chin Kua Oliver Wiens Wolfgang Mo?ner Markus Reifferscheid Nobert Vogl Gernot Hackl Gerald Nitzl 潘秀兰 | 2014 | 世界钢铁2014，，1： | 2 |
| 9 | Interfacial microstructure and mechanical properties of aluminium-zinc-coated steel joints made by a modified metal inert gas welding-brazing process显示文摘 | ZHANG H T FENG J C HE P HACKL H | 2007 | Materials Characterization2007，58，7： | 1 |
| 10 | Prevalence of bo- vine papillomavirus and Treponema DNA in bovine digital dermatitis lesions 显示文摘 | Brandt S Apprich V Hackl V | 2011 | Vet Microbiol2011，148，24： | 1 |
| 11 | ClueGO : a cyto- scape plug-in to decipher functionally grouped gene on- tology and pathway annotation networks显示文摘 | Bindea G Mlecnik B Hackl H A | 2009 | Bioinformat- ics2009，25，8： | 1 |
| 12 | Activating transcriptionfactor-3(ATF3)functions as a tumor suppressor in colon cancer andis up-regulated upon heat-shock protein 90(Hsp90)inhibition显示文摘 | HACKL C LANG S A MOSER C | 2010 | BMC Cancer2010，10，： | 1 |
| 13 | ITS2 database IV:interac-tive taxon sampling for internal transcribed spacer 2 based phylo-genies显示文摘 | Koetschan C Hackl T Muller T | | 0，，03： | 1 |
| 14 | A control chart based on ranks 显示文摘 | Hackl P Ledolter J | 1991 | Journal of Quality Technology1991，23，： | 1 |
| 15 | Passivation of chalcopyrite during oxidative leaching in sulfate media显示文摘 | Hackl R Dreisinger D Peters E | 1995 | Hydrometallurgy1995，39，13： | 1 |
| 16 | Protein-bound uraemictoxin removal in haemodialysis and post-dilution haemodiafiltration显示文摘 | Krieter DH Hackl A Rodriguez A | 2010 | Nephrol Dial Transplant2010，25，1： | 1 |
| 17 | miR-17-92 cluster ups and downs in cancer and aging 显示文摘 | Grillari J Hackl M Gfillari-~oglauer R | 2010 | Biogerontology2010，4，： | 1 |
| 18 | Coating of carbon short fi- bers with thin ceramic layers by chemical vapor deposition 显示文摘 | Hackl G Gerhard H Popovska N | 2006 | Thin Solid Films2006，513，12： | 1 |
| 19 | miR-17-92 cluster: ups and downs in cancer and aging 显示文摘 | Grillari J Hackl M Grillari-Voglauer R | 2010 | Biogerontology2010，11，4： | 1 |
| 20 | Diagnostic Value of Contrast-Enhanced Magnetic Resonance Imaging and Single-Photon Emission Computed Tomography for Detection of Myocardial Necrosis Early After Acute Myocardial Infarction显示文摘 | Tareq Ibrahim Hubertus P. Bülow Thomas Hackl Mira H?rnke Stephan G. Nekolla Martin Breuer Albert Sch?mig Markus Schwaiger | 2007 | Journal of the American College of Cardiology2007，，2： | 1 |
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