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| 1 | Systemic treatment for inoperable pancreatic adenocarcinoma: review and update显示文摘There have been many clinical trials conducted to evaluate novel systemic regimens for unresectable pancreatic cancer. However, most of the trial results were negative, and gemcitabine monotherapy has remained the standard systemic treatment for years. A number of molecular targeted agents, including those against epidermal growth factor receptor and vascular endothelial growth factor receptors, have also been tested. In recent years, there have been some breakthroughs in the deadlock: three regimens, namely gemcitabine-erlotinib, FOLFIRINOX, and gemcitabine-nab-paclitaxel, have been shown to prolong the overall survival of patients when compared with gemcitabine monotherapy. In addition, emerging data suggested that the membrane protein human equilibrative nucleotide transporter 1 is a potential biomarker with which to predict the efficacy of gemcitabine. Here we review the literature on the development of systemic agents for pancreatic cancer, discuss the current choices of treatment, and provide future directions on the development of novel agents. | Stephen L.Chan Sin T.Chan Eric H.Chan Zhe-Xi He | 2014 | Chinese Journal of Cancer2014，33，6： | 2 |
| 2 | Development of a non‐invasive algorithm with transient elastography (Fibroscan) and serum test formula for advanced liver fibrosis in chronic hepatitis B显示文摘 | G. L. H.WONG V. W. S.WONG P. C. L.CHOI A. W. H.CHAN H. L. Y.CHAN | 2010 | Alimentary Pharmacology & Therapeutics2010，，10： | 2 |
| 3 | Effects of skin temperature on lesion size in fractional photothermolysis显示文摘 | HansLaubach Henry H.Chan FranciscaRius R. RoxAnderson DieterManstein | 2007 | Lasers Surg. Med2007，，1： | 1 |
| 4 | Effects of long‐term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis显示文摘 | Yao‐ChungChuang Hung‐YiChuang Tsu‐KungLin Chiung‐ChihChang Cheng‐HsienLu Wen‐NengChang Shang‐DerChen Teng‐YeowTan Chi‐RenHuang Samuel H. H.Chan | 2012 | Epilepsia2012，，1： | 1 |
| 5 | Automating Laser Scanning of 3D Surfaces for Reverse Engineering显示文摘 | Vincent H.Chan ColinBradley Geoffrey W | | 0，，3204： | 1 |
| 6 | On a two‐dimensional energy balance climate model coupled interactively to a land carbon cycle model显示文摘 | Y.‐H.CHAN D.CHAN K.HIGUCHI | 2002 | Tellus B2002，，3： | 1 |
| 7 | Itch characteristics in Chinese patients with atopic dermatitis using a new questionnaire for the assessment of pruritus显示文摘 | G.Yosipovitch A. T. J.Goon J.Wee Y. H.Chan I.Zucker C. L.Goh | 2002 | International Journal of Dermatology2002，，4： | 1 |
| 8 | GADD34 protein levels increase after transient ischemia in the cortex but not in the CA1 subfield: implications for post‐ischemic recovery of protein synthesis in ischemia‐resistant cells显示文摘 | WulfPaschen TakeshiHayashi AtsushiSaito Pak H.Chan | 2004 | Journal of Neurochemistry2004，，3： | 1 |
| 9 | Development of a non‐invasive algorithm with transient elastography (Fibroscan) and serum test formula for advanced liver fibrosis in chronic hepatitis B显示文摘 | G. L. H.WONG V. W. S.WONG P. C. L.CHOI A. W. H.CHAN H. L. Y.CHAN | 2010 | Alimentary Pharmacology & Therapeutics2010，，10： | 1 |
| 10 | Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians显示文摘 | Nicola P.Y.Chan Stephanie G.Y.Ho Chi K.Yeung Samantha Y.N.Shek Henry H.Chan | 2010 | Lasers Surg. Med2010，，： | 1 |
| 11 | Prevalence of undiagnosed diabetes and postchallenge hyperglycaemia in Chinese patients with non‐alcoholic fatty liver disease显示文摘 | V. W. S.WONG A. Y.HUI S. W. C.TSANG J. L. Y.CHAN G. L. H.WONG A. W. H.CHAN W. Y.SO A. Y. S.CHENG P. C. Y.TONG F. K. L.CHAN J. J. Y.SUNG H. L. Y.CHAN | 2006 | Alimentary Pharmacology & Therapeutics2006，，8： | 1 |
| 12 | A Comparative study of intense pulsed light alone and its combination with photodynamic therapy for the treatment of facial acne in Asian skin显示文摘 | Chi K.Yeung Samantha Y.Shek PeterBjerring Carol S.Yu TaroKono Henry H.Chan | 2007 | Lasers Surg Med2007，，1： | 1 |
| 13 | 新加坡特应性皮炎患者及对照的空气变应原过敏斑贴试验显示文摘The role of allergy in atopic dermatitis is controversial. The atopy patch test (APT) has been used to investigate the association between atopic dermatitis and aeroallergen allergy.To determine the proportion of patients with atopic dermatitis with positive patch tests to common local aeroallergens and to compare this to controls with and without respiratory atopy, we performed APT, skin- prick tests (SPT) and IgE radioallergosorbent tests (RAST) on 73 patients with atopic dermatitis and on 38 nonatopic controls (13 with and 25 without respiratory atopy). The allergens used were house dust mite, cat dander, Bermuda grass and German cockroach. Only the APT for house dust mite showed a significant difference between the two groups. APT for house dust mite correlated with the RAST test, while APT for cat fur correlated with the SPT. The APT may be useful to evaluate aeroallergens in atopic dermatitis,but further work is needed to make it more reliable. | Goon A. Leow Y.- H.Chan Y.- H. 潘敏 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，2： | 0 |
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