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| 1 | Novel pharmacological therapy in type 2 diabetes mellitus with established cardiovascular disease: Current evidence显示文摘Cardiovascular diseases(CVDs) remain the leading cause of death in the world and in most developed countries. Patients with type 2 diabetes mellitus(T2DM)suffer from both microvascular and macrovascular diseases and therefore have higher rates of morbidity and mortality compared to those without T2DM. If current trends continue, the Center for Disease Control and Prevention estimates that 1 in 3 Americans will have T2DM by year 2050. As a consequence of the controversy surrounding rosiglitazone and the increasing prevalence of diabetes and CVDs, in 2008 the Food and Drug Administration(FDA) established new expectations for the evaluation of new antidiabetic agents, advising for pre and,in some cases, post-marketing data on major cardiovascular events. As a direct consequence, there has been a paradigm shift in new antidiabetic agents that has given birth to the recently published American Diabetes Association/European Association for the Study of Diabetes consensus statement recommending sodium-glucose cotransporter-2 inhibitors(SGLT2i) and glucagon like peptide-1 receptor agonists(GLP-1RA) in patients with T2DM and established CVD. As a result of over a decade of randomized placebo controlled cardiovascular outcome trials, the aforementioned drugs have received FDA approval for risk reduction of cardiovascular(CV) events in patients with T2DM and established CV disease.SGLT2i have been shown to have a stronger benefit in patients with congestiveheart failure and diabetic kidney disease when compared to their GLP-1RA counterparts. These benefits are not withstanding additional considerations such as cost and the multiple FDA Black Box warnings. This topic is currently an emerging research area and this mini-review paper examines the role of these two novel classes of drugs in patients with T2DM with both confirmed, and at risk for, CVD. | Leonardo Pozo Fatimah Bello Andres Suarez Francisco E Ochoa-Martinez Yamely Mendez Chelsea H Chang Salim Surani | 2019 | World Journal of Diabetes2019，10，5： | 2 |
| 2 | Endotoxemia stimulates skeletal muscle Na+-K+-ATPase and raises blood lactate under aerbic conditions in humans显示文摘 | Bundgaard H Kjeldsen K Suarez Krabbe K | 2003 | Am J Physiol Heart Circ Physiol2003，284，3： | 1 |
| 3 | Evaluation of BTEX remediation by natural attenuation at a coastal facility 显示文摘 | Suarez M P Rifai H S | 2002 | Ground Water Monitoring Remediation2002，，22： | 1 |
| 4 | Protection of chickens against avian influenza with non--replicating adenovirus--vectored vaccine 显示文摘 | Toro H H Tang D C Suarez D L | 2008 | Vaccine2008，26，： | 1 |
| 5 | Converting enzyme inhibition and kidney function in normotensive diabetic patients with persistent microalbuminuria显示文摘 | Leblanc H Suarez L | 1987 | Br Med J (Clin Res Ed)1987，294，6585： | 1 |
| 6 | Use of dynamic compliance for open lung positive end - expiratory pressure titration in an experimental study 显示文摘 | Suarez Sipmann F Bohm S H Tusman G | 2007 | Crit Care Med2007，35，1： | 1 |
| 7 | Corona loss characteristics of contaminated conductors in fair weather显示文摘 | Membello E E Ratta G Suarez H D | 2001 | Electric Power Systems Research2001，59，1： | 1 |
| 8 | VEIDase is a principal caspase-like activity involved in plant programmed cell death and essential for embryonic pattern formation显示文摘 | BOZHKOV P V FILONOVA L H SUAREZ M F | 2004 | Cell Death and Differentiation2004，11，： | 1 |
| 9 | Hyperactivation of mammalian spermato- zoa: function and regulation 显示文摘 | Chen-Ho H Suarez S S | 2001 | Reproduction2001，122，： | 1 |
| 10 | An empirical study of manufacturing flexibility in printed circuit board assembly显示文摘 | Fernando Suarez F Michael Cusumano A Charles Fine H | 1996 | Operations Research1996，44，1： | 1 |
| 11 | Cysteine protease mcII-Pa executes programmed cell death during plant embryogenesis显示文摘 | BOZHKOV P V SUAREZ M F FILONOVA L H | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 12 | Converting enzyme inhibition and kidney function in normotensive diabetic patients with persistent microalbuminuria显示文摘 | Marre M Leblanc H Suarez L | 1987 | Br Med J1987，294，： | 1 |
| 13 | Concentrations of polyehlorinated biphenyls (PCBs) in water, sediment, and aquatic biota in the Houston Ship Channel, Texas 显示文摘 | Howell N L Suarez M P Rifai H S | 2008 | Chemosphere2008，70，： | 1 |
| 14 | Fatal outcome of a young woman with papillary thyroid carcinoma and graves' disease: possible implication of 'cross-signalling' mechanism显示文摘 | Cross GA Suarez H Pitoia F | 2008 | Arq Bras Endocrinol Metabol2008，52，7： | 1 |
| 15 | Distribution of polychlorinated dibenzo-p-dioxins and dibenzofurans in suspended sediments, dissolved phase and bottom sediment in the Houston Ship Channel显示文摘 | Suarez M P Rifai H S Palachek R | 2006 | Chemosphere2006，62，： | 1 |
| 16 | Metacaspase-de-pendent programmed cell death is essential for plant embryogenesis显示文摘 | SUAREZ M F FILNONVA L H SMERTENKO A | 2004 | Curr Biol2004，14，： | 1 |
| 17 | Clinical characteristics ofpositional vertigo after mild head trauma 显示文摘 | Suarez H Alonso R Arocena M | 2011 | Acta Otolaryngol2011，131，4： | 1 |
| 18 | Concentrations of polychlorinated biphenyls (PCBs) in water, sediment, and aquatic biota in the Houston Ship Channel, Texas 显示文摘 | Howell N L Suarez M P Rifai H S | 2008 | Chemosphere2008，70，4： | 1 |
| 19 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 20 | Antinociceptive interactions between al-pha-2 adrenergic and opiate agonists at the spinal level in rodents 显示文摘 | Ossipov M H Suarez L J Spaulding T C | 1989 | Anesth Analg1989，68，3： | 1 |
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