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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 4 | Role of DL-lactic acid as an intermediate in rumen metabolism of dairy cows显示文摘 | COUNOTTE G H M LANKHORST A PRINS R A | 1983 | Journal of Animal Science1983，56，： | 1 |
| 5 | Carbon-supported sulfide catalysts显示文摘 | DUCHET J C Van OERS E M De BEER V H J PRINS R | 1983 | J Catal1983，80，2： | 1 |
| 6 | Bicarbonate utilization:function and mechanism显示文摘 | Prins H B A Elzenga J T M | 1989 | Aquatic Botany1989，34，1： | 1 |
| 7 | Efficacy and safety of the oral direct factor X a inhibitor apixaban for symptoma- tic deep vein thrombosis: the Botticelli DVT dose-ranging study 显示文摘 | Buller H Deitchman D Prins M | 2008 | J Thromb Haemost2008，6，： | 1 |
| 8 | Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs显示文摘 | Briejer M R Prins N H Schuurkes J A | 2001 | Neurogastroenterol Motil2001，13，： | 1 |
| 9 | Regulation of lactate metabolism in the rumen显示文摘 | COUNOTFE G H M PRINS R A | 1981 | Veterinary Research Communi- cation1981，5，1： | 1 |
| 10 | The effect of cognitive behavior therapy for chronic fatigue syndrome on self- reported cognitive impairments and neuropsychological test performance 显示文摘 | Kncop H Prins JB Stulemeijer M | 2007 | J Neurol Neurosurg Psychiatry2007，78，4： | 1 |
| 11 | Global environmental controls of diversity in large herbivores显示文摘 | Olff H Ritchie M E Prins H H T | 2002 | Nature2002，415，： | 1 |
| 12 | Regulation of lactate metabolism in the rumen显示文摘 | Countte G H M Prins R A | 1981 | Veterinary Research Communications1981，5，1： | 1 |
| 13 | Regulation of lactate metabolism in the rumen显示文摘 | COUNOTTE G H M PRINS R A | 1981 | Veterinarijair Research Communication1981，，5： | 1 |
| 14 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 15 | Bicarbonate utilization:function and mechanism显示文摘 | Prins H B A Elzenga J T M | 1989 | Aquatic Botany1989，34，： | 1 |
| 16 | Structure of molybdenum sulfide in carbon supported Mo and CoMo sulfide catalysts as studied by extended X-ray absorption fine structure spectroscopy显示文摘 | Bouwens S M A M Prins R de Beer V H J | 1990 | J Phys Chern1990，94，： | 1 |
| 17 | The effect of cognitive behaviour therapy for chronic fatigue syndrome on self-reported cognitive impairments and neuropsychological test performance显示文摘 | Prins JB Stulemeijer M | 2007 | Neurol Neurosurg Psychiatry2007，78，4： | 1 |
| 18 | Some remarks on the viscosity measurement of pyrolysis liquids 显示文摘 | RADOVANOVIC M VENDERBOSCH R H PRINS W | 2000 | Biomass and Bioenergy2000，18，3： | 1 |
| 19 | Role of Megasphaera elsdenii in the fermentation of DL-lactate in the rumen of dairy cattle显示文摘 | Counotte G H M Prins R A Janssen R H A M | 1981 | App Environ Microbiol1981，42，： | 1 |
| 20 | Reversible electrowetting and trapping of charge:Model and experiments显示文摘 | Verheijen H J J Prins M W J | 1999 | Langmuir1999，15，20： | 1 |
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