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| 1 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | Metabolic and hepatic effects of liraglutide,obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To evaluate the pharmacodynamics of compounds in clinical development for nonalcoholic steatohepatitis(NASH) in obese mouse models of biopsy-confirmedNASH.METHODS Male wild-type C57 BL/6 J mice(DIO-NASH) and Lep^(ob/ob)(ob/ob-NASH) mice were fed a diet high in trans-fat(40%), fructose(20%) and cholesterol(2%) for 30 and 21 wk, respectively. Prior to treatment, all mice underwent liver biopsy for confirmation and stratification of liver steatosis and fibrosis, using the nonalcoholic fatty liver disease activity score(NAS) and fibrosis staging system. The mice were kept on the diet and received vehicle, liraglutide(0.2 mg/kg, SC, BID), obeticholic acid(OCA, 30 mg/kg PO, QD), or elafibranor(30 mg/kg PO, QD) for eight weeks. Within-subject comparisons were performed on changes in steatosis, inflammation, ballooning degeneration, and fibrosis scores. In addition, compound effects were evaluated by quantitative liver histology, including percent fractional area of liver fat, galectin-3, and collagen 1 a1.RESULTS Liraglutide and elafibranor, but not OCA, reduced body weight in both models. Liraglutide improved steatosis scores in DIO-NASH mice only. Elafibranor and OCA reduced histopathological scores of hepatic steatosis and inflammation in both models, but only elafibranor reduced fibrosis severity. Liraglutide and OCA reduced total liver fat, collagen 1 a1, and galectin-3 content, driven by significant reductions in liver weight. The individual drug effects on NASH histological endpoints were supported by global gene expression(RNA sequencing) and liver lipid biochemistry.CONCLUSION DIO-NASH and ob/ob-NASH mouse models show distinct treatment effects of liraglutide, OCA, and elafibranor, being in general agreement with corresponding findings in clinical trials for NASH. The present data therefore further supports the clinical translatability and utility of DIO-NASH and ob/ob-NASH mouse models of NASH for probing the therapeutic efficacy of compounds in preclinical drug development for NASH. | Kirstine S Tolbol Maria NB Kristiansen Henrik H Hansen Sanne S Veidal Kristoffer TG Rigbolt Matthew P Gillum Jacob Jelsing Niels Vrang Michael Feigh | 2018 | World Journal of Gastroenterology2018，24，2： | 5 |
| 4 | 柔性直流输电并网风电厂的低电压穿越能力改进(英文)显示文摘To achieve active control of the AC voltage magnitude of wind power plant(WPP)collector network and improve the fault ride-through(FRT)capability,an FRT scheme based on feed forward DC voltage control is presented for voltage source converter-high voltage direct current(VSC-HVDC)connected offshore WPPs.During steady state operation,an open loop AC voltage control is implemented at the WPP-side VSC of the HVDC system so that any possible control interactions between WPP-side VSC and VSC of wind turbine are minimized.Whereas during any grid fault,a dynamic AC voltage reference is made according to both the DC voltage error and AC active current from the WPP collector system,thus ensuring fast and robust FRT of the VSC-HVDC-connected offshore WPPs.Under the unbalanced fault condition in the host power system,the resulting oscillatory DC voltage is directly used in the VSC AC voltage controller at the WPP side so that the WPP collector system voltage also reflects the unbalance in the main grid.Time domain simulations are performed to verify the efficacy of the FRT scheme based on the proposed feed forward DC voltage control.Simulation results show satisfactory FRT responses of the VSC-HVDC-connected offshore WPP under balanced and unbalanced faults in the host power system,as is shown under a serious fault in the WPP collector network. | Ranjan SHARMA Qiuwei WU Seung Tae CHA Kim Hφj JENSEN Tony Wederberg RASMUSSEN Jacob ΦSTERGAARD | 2015 | 电力系统自动化2015，39，3： | 4 |
| 5 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 6 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 7 | Defining the specific physiological requirements for c- Myc in T cell development显示文摘 | Douglas NC Jacobs H Bothwell AL | 2001 | Nat Immunol2001，2，4： | 2 |
| 8 | 普萘洛尔治疗婴幼儿血管瘤导致1例患儿体温变化显示文摘婴幼儿血管瘤在出生后几个月内迅速增殖,如不及时干预,常常遗留瘢痕、溃疡,更为严重的并发症会导致失明、气道阻塞等。目前的治疗方法包括手术、激光治疗及药物治疗等。普萘洛尔是美国药品食品监督管理局唯一许可的治疗血管瘤的药物,由于其亲脂特性,能够通过血脑屏障,增加中枢神经系统受到影响的风险。该文作者报告1例左前臂、躯干、臀部和鼻尖血管瘤的早产儿,放入保温箱时采用普萘洛尔治疗,结果无法脱离保温箱。 | Burkey BW Jacobs JA Aziz H 张凌 | 2017 | 中国口腔颌面外科杂志2017，15，4： | 2 |
| 9 | Sediment-related growth limitation of Elodea nuttallii as indicated by a fertilization experiment显示文摘 | BEST E P WOLTMAN H JACOBS F H | 1996 | Fresh Water Biology1996，36，： | 1 |
| 10 | Superresolution reconstruction and its im pact on sensor performance显示文摘 | Cha J H Jacobs E | 2005 | SPIE2005，5784，： | 1 |
| 11 | Mesh Saliency显示文摘 | LEE C H VARSHNEY A JACOBS D W | 2005 | ACM Transaction on Graph2005，24，3： | 1 |
| 12 | Token+constraint systems for tangible interaction with digital information 显示文摘 | Ullmer B Ishii H Jacob R J K | 2005 | A CM Transactions on Computer Human Interaction2005，12，1： | 1 |
| 13 | Endometrial cytosolic and nuclear progesterone receptors in the luteal phase defect显示文摘 | Jacobs M H Balasch J Gonzalez M J | 1987 | J Clin Endocrinol Metab1987，64，3： | 1 |
| 14 | A highly specific and sentitive sandwich blocking ELISA based on baculovirus expressed pseudorabies virus glycoprotein B 显示文摘 | Gut-Winiarska M Jacobs L Kerstens H | 2000 | J Virol Methed2000，88，1： | 1 |
| 15 | Evidence for the nature of true Lewis sites in faujasite - type zeolites显示文摘 | JACOBS P A H K BEYER | 1979 | J Phys Chem1979，83，9： | 1 |
| 16 | An 8-year record of the seasonal variation of ^2H and ^18O in atmospheric water vapour and precipitation at Heidelberg Germany显示文摘 | Jacob H Sonntag C | 1991 | Tellus1991，43，： | 1 |
| 17 | Effective prevention of microbial biofilm formation on medical devices by low-energy surface acoustic waves显示文摘 | Hazan Z Zumeris J Jacob H | 2006 | Antimicrob Agents Chemother2006，50，12： | 1 |
| 18 | Leukotriene receptor antag-onism and the prevention of extracellular matrix degradation duringatherosclerosis and in-stent stenosis显示文摘 | Hlawaty H Jacob MP Louedec L | 2009 | Arterioscler Thromb VascBiol2009，29，4： | 1 |
| 19 | Thermal and hydraulic design of di-rect contact spray columns for use in extracting geo-thermal brines 显示文摘 | JACOBS H R | 1988 | Hemisphere1988，11，52： | 1 |
| 20 | The stimulation of cell proliferation by quercetin is mediates by the estrogen receptor显示文摘 | Vander Woude H Ter Veld MG Jacobs N | 2005 | Mol Nutr Food Res2005，49，8： | 1 |
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