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| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | 适合水稻悬浮培养细胞蛋白质组分析的双向电泳技术显示文摘水稻是研究植物蛋白质组学的一个重要试材,从蛋白质的提取,裂解缓冲液的成份和浓度,第一向聚焦的条件,蛋白上样量和二向胶的选择方面,对水稻悬浮培养细胞的双向电泳条件进行了比较和优化。结果表明,采用甲醇/氯仿沉淀蛋白,裂解缓冲液中加入0.5%的两性电解质、并加入盐桥,17cm的胶条、850μg的上样量可达到较好的等电聚焦效果;8%-16%梯度胶分离蛋白较为适宜。 | 刘悦萍 杨爱珍 郭蓓 余萍 Horvath Gabor V Gyula Orosz | 2010 | 生物技术通报2010，26，11： | 2 |
| 3 | Isopropanol dehydration by pervaporation显示文摘 | Ramadan A Gyula V Erika Bek A M | 1999 | Chem Eng Proc1999，38，2： | 1 |
| 4 | Production of a defensin-like antifungal protein NFAP from Neosartorya fischeri in Pichia pastoris and its antifungal activity against filamentous fungal isolates from human infections显示文摘 | Máté Virágh Dóra V?r?s Zoltán Kele Laura Kovács ádám Fizil Gergely Lakatos Gergely Maróti Gyula Batta Csaba Vágv?lgyi László Galgóczy | 2014 | Protein Expression and Purification2014，，： | 1 |
| 5 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 6 | Evaluation of cor- porate environment management approaches A framework and ap- plication显示文摘 | GYULA V SANDOR K DENNIS A R | 1996 | Int J Production Economics1996，43，： | 1 |
| 7 | Investigation of Ultra- and Nanoftltration for utilization of Whey Protein and Lactose 显示文摘 | RAMADAN A GYULA V | 2005 | Journal of Food Engineering2005，67，： | 1 |
| 8 | Production of alcohol free wine by pervaporation显示文摘 | LA' SZLO' T GYULA V KORNE' L K | 2007 | J Food Eng2007，，78： | 1 |
| 9 | Causal modeling alternatives in operations research:overview and application显示文摘 | RONALD D GYULA V | 2004 | European Journal of Operational Research2004，156，1： | 1 |
| 10 | Investigation of ultra-and nanofil- Iration for utilization of whey protein and lactose 显示文摘 | Ramadan A Gyula V | 2005 | Journal of Food Engineering2005，67，3： | 1 |
| 11 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 12 | Detection of four lymphotropic herpesviruses in Hungarian Patients with multiple myeloma and lymphoma显示文摘 | Márta Csire Gábor Mikala Mónika Pet? Judit Jánosi Attila Juhász Attila Tordai János Jákó Gyula Domján János Dolgos Gy?rgy Berencsi István Vályi‐Nagy | 2007 | FEMS Immunology & Medical Microbiology2007，，： | 1 |
| 13 | Effect of irrigation water containing arsenic on elemental composition of bean and lettuce plants cultivated in calcareous sandy soil显示文摘Background:The uptake of arsenic by vegetables from soil irrigated with arsenic enriched groundwater poses a major health hazard.The edible portion of these vegetables transfer arsenic to the human beings.The uptake of arsenic was studied in bean(Phaseolus vulgaris L.)and lettuce(Lactuca sativa L.)in a controlled greenhouse pot culture with calcareous sandy soil as substrate.The plants were irrigated with water containing sodium arsenate at concentrations 0.1,0.25 and 0.5 mg L^(-1).The total arsenic concentration of the different plants parts was determined by ICP-MS,following microwave-assisted acid digestion.The change in plant biomass production and essential macroelements(Mg,P,K)and microelements concentration(Fe,Mn,Cu,Zn)was also studied.Results:The As concentration in the bean was in the order:root>stem>leaf>bean fruit and in lettuce:root>leaves.At the highest dose(0.5 mg L^(-1))the As concentration in the bean fruit and lettuce leaves was 22.1μg kg^(-1)and 1207.5μg kg^(-1)DW,respectively.Increasing As concentration in the irrigation water resulted in decreased edible biomass production in bean,while in lettuce the edible biomass production increased.Neither plant exhibited any visible toxicity symptoms.No significant change was observed in the macro and microelements concentration.The total and the water-soluble arsenic in soil amounted to 3.5 mg kg^(−1)and 0.023 mg kg^(−1),respectively.The transfer factor was found to increase with increase in the As treatment applied.The transfer factor range for bean from root to fruit was 0.003–0.005,and for lettuce from root to leaves was 0.14–0.24.Conclusion:Considering the FAO-WHO recommended maximum tolerable daily intake(MTDI)limit of 2.1μg kg^(-1)body weight,and the biomass production,both plants should not be cultivated at As treatment level higher than 0.1 mg L^(-1). | Sirat Sandil Péter Dobosy Krisztina Kröpfl Anna Füzy MihályÓvári Gyula Záray | 2019 | Food Production, Processing and Nutrition2019，1，1： | 0 |
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