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    题名 作者 年代 出处 被引量
1Intratumoral dendritic cell vaccin ation elicits potent tumoricidal im munity against malignant glioma in rats显示文摘Dendritic cells(DC)are attractive candidates for innovative cancer immunotherapy by virtu e of their ability to function as powe rful antigen presenting cells and elicit potent antitumor cytotoxic immune r esponses.With the aim of generating antitumor immunity,the authors sought to enhance in vivo tum or antigen presentation by using an i ntratumoral DC vaccination strateg y in the setting of partially irradiated intracranial brain tumo rs.Fisher rats,implanted with 9L gliomas in the right corpus striatum,w ere treated with freshly cultured,unpulsed syngeneic DC inoculated directly into the tumor bed.Intracranially inoculated DCs were found to drain to ipsilateral deep cervical lymph nodes.This was a ssociated with increased local and s ystemic antitumor cytoxicity,as evidenced by robust infiltration of treated tumors with CD4and CD8T ce lls as well as by increased IFN-gamma protein and message levels in in vitr o restimulated splenic lymphocytes.DC therapy resulted in prolonged survival and immunity to s ubsequent intracranial tumor re-ch allenge.These results demonstrate the viability of intratumoral DC vaccination as an effectiv e therapeutic strategy for intracra nial glioma.Ehtesham M Kabos P Gutierrez MA Samoto K Black KL Yu JS 2003癌症2003,22,7:8
2Effects of vertebrate predation on a caviomorph rodent, the degu (Octodon degus), in a semiarid thorn scrub community of Chile 显示文摘Meserve P L Gutierrez J R Jaksic F M 1993Oecologia1993,94,:2
3Study of the calcification of bovine pericardium: Analysis of the implication of lipids and proteogly cans显示文摘Herrero E J Fernandez P Gutierrez M 1991Biomaterials1991,12,:1
4Cytotoxic constituents from daphnia pulex 显示文摘Perez Gutierrez R M Lule P R 2005Pharmaceutical Biology2005,43,4:1
5GABAA receptor subunit expression changes in the rat cerebellum and cerebral cortex during aging显示文摘Gutierrez A Khan Z U Miralles C P 1997Mol Brain Res1997,45,1:1
6Expression of a bovine kappa-CN eDNA in the mammary gland of transgenie mice utilizing a genomic milk protein gene as an expression cassette显示文摘Gutierrez A Meade H M Ditullio P 1996Transgenie Res1996,5,4:1
7The news vendor problem in a global market:Optimal centralized and decentralized control policies for a two-market stochastic inventory system显示文摘Kouvelis P Gutierrez G J 1997Management Science1997,43,:1
8A robustness approach to uncapacitated network design problems显示文摘Gutierrez G J Kouvelis P Kurawarwala A A 1996European Journal of Operational Research1996,94,2:1
9Flicker characteristics of efficient lighting assessed by the IEC flickermeter显示文摘Azcarate J Gutierrez J Saiz P 2014Electric Power Systems Research2014,,107:1
10Accessibility in the European Union : theimpact of the trans-European road network 显示文摘Gutierrez J Urbano P 1996Journal ofTransport Geography1996,4,1:1
11The role retinoid defi- ciency and estrogens as cofactors in cervical cancer显示文摘GARIGLIO P GUTIERREZ J CORTES E 2009Arch Med Res2009,40,6:1
12The physiological basis of ratio-dependent predator-prey theory: a methbolic pool model of Nicholson's blowflies as an example 显示文摘GUTIERREZ A P 1992Ecology1992,73,:1
13Dry matter production and partitioning in rose (Rosa hybrida) flower shoots显示文摘Gutierrez Colomer R P Gonzalez-Real M M Baille A 2006Scientia Horticulturae2006,107,:1
14Algorithms for robust singleand multiple period layout models for manufacturing systems 显示文摘 Kurawarwala A and Gutierrez G 1992Eur J Oper Res1992,,63:1
15The role of rituximab and chemotherapy in aggressive B-cell lymphoma:a preliminary report of dose-adjusted EPOCH-R显示文摘Wilson WH Gutierrez M O′Connor P 2002Semin Oncol2002,29,12:1
16Boar spermatozoa eryopreservation in low glycerol/trehalose enriched freezing media improves cellular integrity显示文摘Gutierrez P O Juarez M D Uribe C S 2009Cryobiology2009,58,:1
17The role of rituximab and chemotherapy in aggressive B-cell lymphoma: a preliminary report of dose- adjusted EPOCH - R显示文摘Wilson W H Gutierrez M O'Connor P 2002Semin Oncol2002,29,12:1
18Catheter ablation of ventricular epicardial tissue: a comparison of standard and cooled-tip radiofrequency energy显示文摘d'Avila A Houghtaling C Gutierrez P 2004Circulation2004,109,:1
19Mixed culture solidsubstrate fermentation of Trichoderma reesei with Aspergillusniger on sugar cane bagasse显示文摘Gutierrez M Portal L Moreno P 1999Bioresour Technology1999,68,:1
20Comparative study of three methods of evaluation of the corneal endothelium inpseudophakic patients:fluorophotometry,specular microscopy and pachymetry显示文摘Beneyto P Gutierrez R Perez T M 1996Grades Arch Clin Exp Ophthalmol1996,234,10:1
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