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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | ,Contribution of Various Constituents of Activated Sludge to Membrane Bioreactor Fouling显示文摘 | Defrance L Jaffrin M Y Gupta B | 2000 | Bioresourse Technology2000，73，： | 1 |
| 3 | Contribution of various constituents of activated sludge to membrane bioreactor fouling 显示文摘 | Defrance L Jaffrin M Gupta B | 2000 | Bioresource Technology2000，73，： | 1 |
| 4 | Serum lipids and uric acid relationship in ischemic thrombotic cerebrovascular disease显示文摘 | Bansal B C Gupta R R Bansal M R | 1975 | Stroke1975，6，： | 1 |
| 5 | Anti - inflammatory and anti- pyretic activities of 13 - sitosterol 显示文摘 | Gupta M B Nath R Srivastava N | 1980 | Planta medica1980，39，6： | 1 |
| 6 | Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 sig- naling显示文摘 | Fillmore C M Gupta P B Rudnick J A | 2010 | Proc Natl Acad Sci USA2010，107，21： | 1 |
| 7 | Contribution of various constituents of activated sludge to membrane bioreactor fouling显示文摘 | Defrance L Jaffrin M Y Gupta B | 2000 | Bio-resource Technology2000，73，： | 1 |
| 8 | Hypolipidaemic and anti-inflammatory effects of fixed dose combination of atorvastatin plusezetimibe in Indian patients with dyslipi- daemia显示文摘 | Padhy B M Yadav R Gupta Y K | 2013 | Singapore Med J2013，54，2： | 1 |
| 9 | Telomerase activity in normal leukocytes and in hematologic malignancies显示文摘 | Counter C M Gupta J Harley C B | 1995 | Blood1995，85，9： | 1 |
| 10 | Piezoelectric, dielectric, optical and electrical characterization of solution grown flower-like ZnO nanocrystal显示文摘 | Gupta M K SinhaN Singh B K etal | 2009 | MaterLett2009，63，： | 1 |
| 11 | Gadd45a and Gadd45b protect hematopoietic ceils from UV - induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition 显示文摘 | Gupta M Gupta SK Hoffman B | 2006 | J Biol Chem2006，281，17： | 1 |
| 12 | Transplantation of islet-like cell clusters derived from human dental pulp stem ceils restores normoglycemia in diabetic mice 显示文摘 | Kanafi M M Rajeshwari Y B Gupta S | 2013 | Cytotherapy2013，15，10： | 1 |
| 13 | Poly (ADP-ribose) polymerase-1-deficient mice are protected from angiotensin Ⅱ-induced cardiac hypertrophy显示文摘 | PILLAI J B GUPTA M RAJAMOHAN S B | 2006 | Am J Physiol Heart Circ Physiol2006，291，： | 1 |
| 14 | Expression of interleukin-6 in osteoarthritic chondrocytes and effects of fluid-induced shear on this expression in normal human chondrocytes in vitro显示文摘 | Mohtai M Gupta MK Donlon B | 1996 | J Orthop Res1996，14，1： | 1 |
| 15 | Optimal LQG control across packet-dropping links显示文摘 | GUPTA V HASSIBI B MURRAY R M | 2007 | Systems & Control Letters2007，56，6： | 1 |
| 16 | Contribution of various constituents of activated sludge to memhrane bioreactor fouling显示文摘 | Defiance L Jaffrin M Y Gupta B | | 0，，： | 1 |
| 17 | Induction of immunological refractoriness in adults by meningococcal C polysaccharide vaccination显示文摘 | Granoff D M Gupta R K Belshe R B | 1998 | J Infect Dis1998，178，3： | 1 |
| 18 | Clinical pharmacology of trastu- zumab emtansine (T-DM 1): a unique antibody-drug conjugate in development for the treatment of HER2-posifive cancer显示文摘 | Girish S Gupta M Wang B | 2012 | Cancer Chemother Pharmacol2012，69，5： | 1 |
| 19 | Materials science research and development in India: A scientometric a- nalysis of international collaborative output 显示文摘 | Mohan S Gupta B M Dhawan S M | 2003 | DESI- DOC Bulletin of Information Technology2003，23，2： | 1 |
| 20 | Cryopreservation of shoot tips of blackberry and raspberry by encapsulation-dehydration and vitrification显示文摘 | Gupta S Reed B M | 2006 | Cryo-Letters2006，27，1： | 1 |
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