|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | ,Contribution of Various Constituents of Activated Sludge to Membrane Bioreactor Fouling显示文摘 | Defrance L Jaffrin M Y Gupta B | 2000 | Bioresourse Technology2000，73，： | 1 |
| 3 | Contribution of various constituents of activated sludge to membrane bioreactor fouling 显示文摘 | Defrance L Jaffrin M Gupta B | 2000 | Bioresource Technology2000，73，： | 1 |
| 4 | Queue - Length and Waiting Time Distributions of Discrete - Time GIx/Geom/1 Queueing Systems with Early and Late Arrivals 显示文摘 | Chaudhry M L Gupta U | 1997 | Queuing Systems1997，25，2： | 1 |
| 5 | Contribution of various constituents of activated sludge to membrane bioreactor fouling显示文摘 | Defrance L Jaffrin M Y Gupta B | 2000 | Bio-resource Technology2000，73，： | 1 |
| 6 | Modelling of Corex Process for Optimisation of OperatiOnal Parameters显示文摘 | Prachethan Kumar P Garg L M Gupta S S | 2006 | Ironmaking and Steelmaking2006，33，1： | 1 |
| 7 | The tribological properties of AI-CulSiCp metal-matrix composites fabricated using the rheocasting technique 显示文摘 | LIM S C GUPTA M REN L KWOK J K M | 1999 | Journal of Materials Processing Technolog1999，8090，： | 1 |
| 8 | Program Slicing-Based Re- gression Testing Techniques 显示文摘 | Gupta R Harrold M J Sofia M L | 1996 | Software: Testing Verification and Reliability1996，6，2： | 1 |
| 9 | In vivo and in vitro studies of a functional peroxisome proliferator-activat- ed receptor gamma response element in the mouse pdx-1 promoter 显示文摘 | Gupta D Jetton T L Mortensen R M | 2008 | J Biol Chem2008，283，32： | 1 |
| 10 | Mg-based composite reinforced by Mg2Si显示文摘 | Lu L Tong K K Gupta M | 2003 | Compos Sci Technol2003，63，5： | 1 |
| 11 | lnter显示文摘 | NAI S M L WEI J GUPTA M | 2009 | Journal of Alloys and Compounds2009，413，12： | 1 |
| 12 | Emergency cervical cerclage:Predictors of success显示文摘 | Gupta M Emary K Impey L | 2010 | J Matern Fetal Neonatal Med2010，23，7： | 1 |
| 13 | Utilizing con- forrnational changes for patterning thin films of recombinant spider silk proteins 显示文摘 | YOUNG S L GUPTA M HANSKE C | 2012 | Biomacromolecules2012，13，10： | 1 |
| 14 | Experiences of burnout and coping strategies utilized by occupational therapists显示文摘 | Gupta S Paterson M L Lysaght R M | 2012 | Canadian Journal of Occupational Therapy2012，79，： | 1 |
| 15 | Cellular ions in NIDDM:relation of calcium to hyperglycemia and cardiac mass显示文摘 | Barbagallo M Gupta R K Resnick L M | 1996 | Diabetes Care1996，19，12： | 1 |
| 16 | The generalized sequence spaces c,c0 l1and l∞ and their Kthe duals显示文摘 | GUPTA M KAMTHAN P K RAO K L N | 1976 | Tamkang J Math1976，7，： | 1 |
| 17 | Contribution of various constituents of activated sludge to memhrane bioreactor fouling显示文摘 | Defiance L Jaffrin M Y Gupta B | | 0，，： | 1 |
| 18 | Association between the transmembrane region polymorphism of MHC class ichain related gene- A and type Ⅰ diabetes mellitus in sweden显示文摘 | Gupta M Nikitina-Zake L Zarghami M | 2003 | Hum Immunol2003，64，： | 1 |
| 19 | Study of tendon profiles in prestressed steel plate girder 显示文摘 | Ronghe G N Gupta L M Paramatic | 2002 | Advance in Structural Engineering2002，5，2： | 1 |
| 20 | Region scheduling:an approach for detecting and redistributing parallelism显示文摘 | R Gupta M L Soffa | 1990 | IEEE Trans on Software Engineering1990，16，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员