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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Biomechanical and computer analysis of radial head prostheses显示文摘 | Ganesh G Gupta George Lucas Dustan L Hahn | 1997 | Journal of Shoulder and Elbow Surgery1997，，1： | 2 |
| 3 | ,Contribution of Various Constituents of Activated Sludge to Membrane Bioreactor Fouling显示文摘 | Defrance L Jaffrin M Y Gupta B | 2000 | Bioresourse Technology2000，73，： | 1 |
| 4 | Contribution of various constituents of activated sludge to membrane bioreactor fouling 显示文摘 | Defrance L Jaffrin M Gupta B | 2000 | Bioresource Technology2000，73，： | 1 |
| 5 | In vitro antioxidant activity of piperine显示文摘 | Mittal R Gupta R L | 2000 | Methods Find Exp Clin Pharmacol2000，22，5： | 1 |
| 6 | Cytogenetic effects of cypermethrin and fenvalerate on the root meristem cells of A Ilium cepa显示文摘 | Chauhan L K S Saxena P N Gupta S K | 1999 | Environ Experi Botany1999，42，3： | 1 |
| 7 | Comparative analysis of genetic diversity among Indian populations of Scirpophaga incertulas by ISSR-PCR and RAPD-PCR显示文摘 | Kumar L S Sawant A S Gupta V S | 2001 | Biochem Genet2001，39，： | 1 |
| 8 | Fragmentation Behavior of Pyrite and Calcite During High-Temperature Processing and Mathematical Simulation 显示文摘 | Yan L Gupta R P Wall T F | 2001 | Energy and Fuels2001，15，2： | 1 |
| 9 | On the moments of residual life in reliability and some characterization results 显示文摘 | GUPTA P L GUPTA R C | 1983 | Communications in Statistics1983，12，4： | 1 |
| 10 | Aggregate Savings, Financial Intermediation and Interest Rate 显示文摘 | Gupta K L | 1987 | Review of Economics and Statistics1987，，69： | 1 |
| 11 | Spontaneous rupture of the spleen secondary to metastatic carcinoma显示文摘 | Gupta PB Harvey L | 1993 | Br J Surg1993，80，： | 1 |
| 12 | Heat-treated Iron(III) Tetramethoxyphenyl Porphyrin Supported on High -Area Carbon as an Electrocatalyst for Oxygen Reaction 显示文摘 | GOJKOVIE S L GUPTA S SAVINELL R F | 1998 | J Electrochem Soc1998，145，10： | 1 |
| 13 | Optical coherence tomography as a rapid, accurate, noncontact method of visualizing the palisades of Vogt显示文摘 | Lathrop KL Gupta D Kagemann L | 2012 | Invest Ophthalmol Vis Sci2012，53，3： | 1 |
| 14 | Levonorgestrel intrauterine system versus medical therapy for menorrhagia 显示文摘 | Gupta J Kai J Middleton L | 2013 | N Engl J Med2013，368，2： | 1 |
| 15 | Queue - Length and Waiting Time Distributions of Discrete - Time GIx/Geom/1 Queueing Systems with Early and Late Arrivals 显示文摘 | Chaudhry M L Gupta U | 1997 | Queuing Systems1997，25，2： | 1 |
| 16 | Bilateral bullous Retinal detachment as a complication of the HELLP syndrome显示文摘 | GUPTA L Y MANSOUR S E | 1994 | Can J Ophthalmol1994，29，5： | 1 |
| 17 | Artifical neural network modeling of the rainfall-runoff process显示文摘 | HSU K L GUPTA H V SOROOSHIAN S | 1995 | Water Resources Research1995，31，： | 1 |
| 18 | Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures显示文摘 | MALAVAL L MODROWSKI D GUPTA A K | 1994 | J Cell Physiol1994，158，3： | 1 |
| 19 | Contribution of various constituents of activated sludge to membrane bioreactor fouling显示文摘 | Defrance L Jaffrin M Y Gupta B | 2000 | Bio-resource Technology2000，73，： | 1 |
| 20 | Modelling of Corex Process for Optimisation of OperatiOnal Parameters显示文摘 | Prachethan Kumar P Garg L M Gupta S S | 2006 | Ironmaking and Steelmaking2006，33，1： | 1 |
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