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| 1 | Anticancer,antiobesity,and anti-inflammatory activity of Artemisia species invitro显示文摘OBJECTIVE: To investigate the anticancer, anti-inflammatory, and antiobesity activity of methanol extracts of eight distinct species: Artemisia Stolonifera (AST), Artemisia Selengensis (ASE), Artemisia Japonica, Artemisia Montana, Artemisia Capillaris (ACA), Artemisia Sylvatica (ASY), Artemisia Keiskeana (AKE), and ArtemisiaScoparia (ASC) invitro. METHODS: Antiproliferative activity was investigated in human breast cancer estrogen receptor-a positive T47D and negative HS578T cell lines exposed to theextractsatvariousconcentrations(5-200mg/ mL)for24, 48, and 72 h. For evaluating the anti-inflammatory activity of the extracts, inhibition of nitrite synthesis was investigated in lipopolysaccharide (LPS)-stimulated cultures of macrophages cells exposed to 10, 50, 100, and 200 mg/mL for 24 h. The antiobesity activity of the extracts was determined as triglyceride content and by a lipolysis assay in differentiated 3T3-L1 cells exposed to the ex-tracts for 72 h at the same concentrations described above. RESULTS: All extracts showed similar antiprolifera-tive activity in a doseand time-dependent manner in HS578T cells. Although extracts at lower concentrations and shorter times stimulated growth of T47Dcells,theantiproliferativeeffectsoftheextracts on T47D cells at higher concentrations (>100 mg/ mL) for 72 h were significantly greater than those of HS578T cells. In case of anti-inflammatory activity, some extracts (AST, ASE, ACA, and AKE) significantly reduced nitric oxide production at higher concentrations in the presence of LPS compared with that in control cells. Antiobesity activity was showed with reducing lipid accumulation significantly (>50%) at concentrations above 100 mg/mL in most extracts (except AST and ACA). Additionally, AKE and ASC increased lipolysis by 11%-24% compared with that in the control.CONCLUSION: Artemisia spp. demonstrates potential as bioactive food supplements. | Eunjeong Choi Heesook Park Jehyuk Lee Gunhee Kim | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 12 |
| 2 | Effect of Artemisia species on cellular proliferation and apoptosis in human breast cancer cells via estrogen receptor-related pathway显示文摘OBJECTIVE:To investigate the mechanism underlying the anticancer effect of Artemisia species through the inhibition of cell growth and induction of apoptosis in breast carcinoma cells.METHODS:To evaluate the anticancer activity of methanol extracts of eight Artemisia species(Artemisia stolonifera,Artemisia selengensis,Artemisia japonica,Artemisia Montana,Artemisia capillaris,Artemisia sylvatica,Artemisia keiskeana,and Artemisia scoparia),we first investigated the proliferation of estrogen receptor(ER)-positive MCF-7breast carcinoma cells exposed to 5 or 200 g/mL for72 h.Apoptosis induction was assessed by an Annexin V binding assay in cells exposed to extracts at a high concentration(200 g/mL).To verify the mechanism of apoptosis,ER expression and its related signaling was investigated using an immunoblot assay under the same conditions.RESULTS:MCF-7 cells showed the strongest antiproliferative response to the tested extracts.Howev-er,a biphasic effect was observed:the extracts inhibited proliferation at high concentrations whereas they stimulated it at low ones.ER expression was similarly modulated by the extracts.However,all of the extracts induced apoptosis at a high concentration(200 g/mL).Compared to the control level,exposure to the extracts resulted in a remarkable increase in the shift of cell populations.CONCLUSION:The present study suggests that the tested Artemisia species exerted their anticancer effects through the induction of apoptosis via an ER-related pathway. | Eunjeong Choi Gunhee Kim | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 5 |
| 3 | Optimal Commutation of a BLDCMotor by Utilizing the Symmetric Terminal Voltage显示文摘 | Gunhee H Jang Kim M G | 2006 | IEEETransactions on Magnetics2006，42，10： | 1 |
| 4 | A Scalable Key Management Scheme for Secure Multicasting over Bluetooth Scatternets显示文摘Secure multicasting is one of the major requirementsfor today’s communication arena.And for any kindof secure communication,a key-distribution schemeis the most sensible part.Being a highly promising,low-cost,and emerging wireless technology,Bluetooth has key distribution supports for securemulticasting over its unit one-hop network,piconet.Bluetooth core specification[1]defines basic securityprotocols for key generation,encryption,andauthentication for intra-piconet security.However,not much attention has been paid so far on securingmulticasting over the Bluetooth Scatternet;nevertheless,multicasting is quite a sensible aspectof modern communication arena.Here in this paper,we extend the piconets key distribution scheme topresent a new key management scheme for securemulticasting over Bluetooth Scatternets.Our keymanagement scheme is compatible to the currentBluetooth architecture design as we rely onBluetooth’s existing security algorithms to proposeour resolution. | Subir Biswas Syed Rehan Afzal Jong-bin Koh Mustafa Hasan Gunhee Lee Dong-kyoo Kim | 2008 | China Communications2008，5，2： | 0 |
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