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| 1 | Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CDIO7a显示文摘Dimethyl fumarate (DMF ) 是使用到对待的新药多重硬化(MS ) 病人。这里,我们在生来的杀手(NK ) 的各种各样的活动检验了 DMF 和 DMF 代谢物 monomethyl fumarate (MMF ) 的效果房间。我们证明 MMF 扩充 K562 和 RAJI 肿瘤房间的主要 CD56 +, 然而并非 CD56 −, NK 房间细胞溶解。MMF 为 24 h 在孵化以后在 CD56 +, 然而并非 CD56 −, NK 房间的表面上导致了 NKp46 表示。这效果密切通过这代谢物从这些房间在 CD56 + NK 房间和 Granzyme B 版本的正式就职的表面上与 CD107a 表示的 upregulation 被相关。anti-NKp46 抗体通过 CD56 + NK 房间禁止了 CD107a 的导致 MMF 的 upregulation 和肿瘤房间的细胞溶解。因此,这些结果是第一证明 MMF 扩充肿瘤目标房间的 CD56 + NK 房间细胞溶解,效果通过 NKp46 调停了。这新奇效果在癌症为治疗学或预防的协议建议 MMF 的使用。 | Heidi Vego Kristin L Sand Rune A Hoglund Lars-Egil Fallang Glenn Gundersen Trygve Holmoy Azzam A Maghazachi | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Effects of phosphorus addition on soil microbial biomass and community composition in three forest types in tropical China 显示文摘 | LIU L GUNDERSEN P ZHANG T | 2012 | Soil Biology & Biochemistry2012，44，： | 1 |
| 3 | The synthesis of cost optimal heat exchanger networks:an industrial review of the state of the art显示文摘 | GUNDERSEN T NAESS L | 1988 | Computer Chem Eng1988，12，6： | 1 |
| 4 | Change in soil organic carbon following afforestation of former arable land显示文摘 | Vesterdal Ritter T Gundersen P L | 2002 | Forest Ecology and Management2002，169，12： | 1 |
| 5 | Physician burnout显示文摘 | Gundersen L | 2001 | Annual International Medi- cine2001，135，： | 1 |
| 6 | Entire Function That Share One Value with One or Two of Their Derivatives显示文摘 | Yang L Z | 1998 | J Math Anal Appl1998，223，： | 1 |
| 7 | Unbiased stereological estimation of the total number of neurons in the subdivision of the rat hippocampus using the optical fractionator 显示文摘 | West M Slomianka L Gundersen H | 1991 | Anat Rec1991，231，4： | 1 |
| 8 | Some new, simple and efficient stereological methods and their use in pathological research and diagnosis显示文摘 | Gundersen HJG Bendtsen TF Korbo L | 1988 | APMIS1988，96，5： | 1 |
| 9 | Change in soil organic carbon following afforestation of former arable land显示文摘 | Vesterdal L Rittcr E Gundersen P | 2002 | Forest Ecology and Management2002，169，12： | 1 |
| 10 | Functional neuromuscular junctions formed by embry-onic stem cell-derived motor neurons显示文摘 | Umbach J A Adams K L Gundersen C B Novitch B G | 2012 | PLoS One2012，7，36： | 1 |
| 11 | Some new, simple and ef- ficient stereological methods and their use in pathological research and diagnosis 显示文摘 | Gundersen HJ Bendtsen TF Korbo L | 1998 | APMIS1998，96，5： | 1 |
| 12 | Intimate-partner violence:the need for primary prevention in the community显示文摘 | Gundersen L | 2002 | Ann Intern Med2002，136，8： | 1 |
| 13 | Some new, simple and efficient stereological methods and their use in patholodical research and diagnosis 显示文摘 | Gundersen HJ Bendtsen TF Korbo L | 1988 | APMIS1988，96，5： | 1 |
| 14 | Change in soil organic carbon following afforestation of former arable land显示文摘 | Vesterdal L Ritter E Gundersen P | 2002 | Forest Ecology and Management2002，169，12： | 1 |
| 15 | Some new,simple and efficient stereological methods and their use in pathological research and diagnosis显示文摘 | Gundersen H J G Bendtsen T F Korbo L | 1988 | APMIS1988，96，5： | 1 |
| 16 | Synthesis and Antimycobacterial Activity of 6-Arylpurines: The Re?quirements for the N-9 Substituent in Active Antimyco?bacterial Purines显示文摘 | GUNDERSEN L L JON N M BJRN S | 2002 | J Med Chern2002，45，6： | 1 |
| 17 | Some new,simple and efficient stereological methods and their use in pathological research and diagnosis显示文摘 | Gundersen HJ Bendtsen TF Korbo L | 1988 | APMIS1988，96，5： | 1 |
| 18 | Some new, simple and efficient stereological methods and their use in pathological research and diagnosis 显示文摘 | Gundersen H J G Bendtsen T F Korbo L | 1988 | Acta Pathol Mierobiol Immunol Scand1988，96，5： | 1 |
| 19 | Entire functions that share one value with one or two of their derivatives显示文摘 | GUNDERSEN G G YANG L Z | 1998 | Journal of Mathematical Analysis and Applications1998，233，： | 1 |
| 20 | Physician burnout显示文摘 | | 2001 | Annual International Medicine2001，135，1： | 1 |
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