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| 1 | Apoptosis and Proinflammatory Cytokine Responses of Primary Mouse Microglia and Astrocytes Induced by Human H1N1 and Avian H5N1 Influenza Viruses显示文摘Patients with an influenza virus infection can be complicated by acute encephalopathy and encephalitis. To investigate the immune reactions involved in the neurocomplication,mouse microglia and astrocytes were isolated,infected with human H1N1 and avian H5N1 influenza viruses,and examined for their immune responses. We observed homogeneously distributed viral receptors,sialic acid (SA)-α2,3-Galactose (Gal) and SA-α2,6-Gal,on microglia and astrocytes. Both viruses were replicative and productive in microglia and astrocytes. Virus-induced apoptosis and cytopathy in infected cells were observed at 24 h post-infection (p.i.). Expression of IL-1β,IL-6 and TNF-α mRNA examined at 6 h and 24 h p.i. was up-regulated,and their expression levels were considerably higher in H5N1 infection. The amounts of secreted proinflammatory IL-1β,IL-6 and TNF-α at 6 h and 24 h p.i. were also induced,with greater induction by H5N1 infection. This study is the first demonstration that both human H1N1 and avian H5N1 influenza viruses can infect mouse microglia and astrocytes and induce apoptosis,cytopathy,and proinflammatory cytokine production in them in vitro. Our results suggest that the direct cellular damage and the consequences of immunopathological injury in the CNS contribute to the influenza viral pathogenesis. | Gefei Wang Juan Zhang Weizhong Li Yun Su Yuanli Gao Heng Zhang Guimei Lin Xiaoyang Jiao Kangsheng Li | 2008 | Cellular & Molecular Immunology2008，5，2： | 28 |
| 2 | Effect of bloodletting therapy at local myofascial trigger points and acupuncture at Jiaji(EX-B 2) points on upper back myofascial pain syndrome: a randomized controlled trial显示文摘OBJECTIVE: To observe the clinical efficacy of bloodletting therapy and acupuncture at Jiaji points for treating upper back myofascial pain syndrome(MPS), and compare this with lidocaine block therapy.METHODS: A total of 66 upper back MPS patients were randomly assigned to either the treatment group or the control group in a 1∶1 ratio. The treatment group(n = 33) were treated with bloodletting therapy at local myofascial trigger points and acupuncture at Jiaji(EX-B 2) points; one treatment course consisted of five, single 20-min-treatments with a 2-day break between each treatment. The control group(n = 33) were treated with a lidocaine block at trigger points; one treatment course consisted of five sessions of lidocaine block therapy with a 2-day break between each session. The simplified Mc Gill Scale(SF-MPQ) and tenderness threshold determination were used to assess pain before and after a course of treatment.RESULTS: After the third and fifth treatment, the SF-MPQ values were significantly decreased(P <0.01) and the tenderness thresholds were significantly increased(P < 0.01) in both groups compared with before treatment. There were no significant differences in pain assessments between the two groups after three and five treatments(P >0.05). There were five cases with minor adverse reactions reported in the control patients, while no adverse reactions were reported in the treatment group.CONCLUSION: Bloodletting therapy at local myofascial trigger points and acupuncture at Jiaji points was effective in treating upper back MPS.Clinically, bloodletting and acupuncture therapy had the same efficacy as the lidocaine block therapy, with fewer adverse reactions. | Jiang Guimei Jia Chao Lin Mode | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 5 |
| 3 | Reserach and promotion in Banana tissue culture显示文摘 | LIN Guimei | 2005 | China Tropical Agriculture2005，，6： | 1 |
| 4 | Study on relationbetween banana tissue culture technology and off-type rate显示文摘 | ZOU Yu LIN Guimei WEI Huafang LI Chaosheng LI Xiaoquan MOU Haifei WU Daidong ZHANG Jinzhong | 2008 | Guangxi Horticulture2008，19，6： | 1 |
| 5 | Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection显示文摘To increase the efficiency and accuracy of clinical tumor detection,we explored multiple imaging by preparing carbon quantum dot(CQD)-loaded nanobubbles for ultrasonic fluorescence dual detection.In this experiment,we prepared 1,2-dioleoyl-3-trimethylammonium-propane chloride(DOTAP)cationic liposomes using the film dispersion method and chose perfluoropentane as the core gas material of the nanobubbles.The nanobubbles were coupled with the negatively charged CQDs through the charge effect to prepare the testing agent for two-way diagnosis with ultrasound contrast and fluorescence detection.The formulation and preparation of the loaded CQD liposome nanobubbles were screened.In vivo experiments showed that nanobubbles can be enriched to the tumor site within 5 min,which enables clearer ultrasound imaging and is conducive to tumor detection.We expect CQD-loaded liposome(Lip-CQD)nanobubbles to become a new ultrasonic contrast agent for clinical applications that can provide a basis for early tumor diagnosis and thus earlier treatment. | Yankun ZHANG Bingtao TANG Yu XIN Qiong WU Lan LIU Yunxia WANG Kongxi ZHU Guimei LIN Hongjuan WANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，9： | 0 |
| 6 | Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting显示文摘Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets.The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level,which play a key role in carcinogenesis.Therefore,to improve the therapeutic efficiency of drugs,researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures.In this review,we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations,aiming at providing guidance in the overall design of precise nanomedicine.Additionally,future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine. | Xianglei Fu Yanbin Shi Tongtong Qi Shengnan Qiu Yi Huang Xiaogang Zhao Qifeng Sun Guimei Lin | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 7 | Analysis on Double-difference Earthquake Location and the Seismicity Pattern of the Yangjiang Earthquake Sequences显示文摘The locations of about 400 earthquakes in Yangjiang,Guangdong Province are determined using the double-difference earthquake location algorithm(DDA).The seismicity pattern becomes concentrated from discrete grids.The rupture characteristics of the Yangjiang earthquake sequence show a conjugated distribution in NW and NE directions.The major distribution trends NE and dips NE with an angle of 30° and a length of 30km,and the minor distribution trends NW and dips SE with an angle of 30° and a length of 20km.The focal depth is 5km~15km.The distribution of the Enping earthquake sequence,which is not far from Yangjiang,is NW-trending.The relationship between hypocenter distribution and geological structure is discussed. | Kang Ying Yang Xuan Huang Wenhui Chen Xing Chen Guimei Lin Wei Wu Huadeng | 2008 | Earthquake Research in China2008，22，1： | 0 |
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