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| 1 | Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT,p38 MAPK/NF-κB pathways显示文摘Alcoholic liver disease(ALD)is the most frequent liver disease worldwide,resulting in severe harm to personal health and posing a serious burden to public health.Based on the reported antioxidant and anti-inflammatory capacities of scutellarin(SCU),this study investigated its protective role in male BALB/c mice with acute alcoholic liver injury after oral administration(10,25,and 50 mg/kg).The results indicated that SCU could lessen serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels and improve the histopathological changes in acute alcoholic liver;it reduced alcohol-induced malondialdehyde(MDA)content and increased glutathione peroxidase(GSH-Px),catalase(CAT),and superoxide dismutase(SOD)activity.Furthermore,SCU decreased tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and IL-1βmessenger RNA(mRNA)expression levels,weakened inducible nitric oxide synthase(iNOS)activity,and inhibited nucleotide-binding oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome activation.Mechanistically,SCU suppressed cytochrome P450 family 2 subfamily E member 1(CYP2E1)upregulation triggered by alcohol,increased the expression of oxidative stress-related nuclear factor erythroid 2-related factor 2(Nrf2)and heme oxygenase-1(HO-1)pathways,and suppressed the inflammation-related degradation of inhibitor of nuclear factor-κB(NF-κB)-α(IκBα)as well as activation of NF-κB by mediating the protein kinase B(AKT)and p38 mitogen-activated protein kinase(MAPK)pathways.These findings demonstrate that SCU protects against acute alcoholic liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and suppressing inflammation by regulating the AKT,p38 MAPK/NF-κB pathways. | Xiao ZHANG Zhicheng DONG Hui FAN Qiankun YANG Guili YU Enzhuang PAN Nana HE Xueqing LI Panpan ZHAO Mian FU Jingquan DONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，7： | 0 |
| 2 | Enhanced carrier mobility in MoSe_(2) by pressure modulation显示文摘Two-dimensional(2D)materials hold great potential for the development of next-generation integrated circuits(ICs)at the atomic limit.However,it is still very challenging to build high performance devices.One of the main factors that limit the incorporation of 2D materials into IC technology is their relatively low carrier mobility.Thus,the engineering strategies that focus on optimizing performance continue to emerge.Herein,using a spatiotemporal resolved pump-probe setup,the carrier transport performance and relaxation process of few-layer and bulk MoSe_(2) under pressure were investigated nondestructively and simultaneously.Our results show that pressure can tune the transport performance effectively.In particular,under pressure regulation,the carrier mobility of the bulk MoSe_(2) increases by~4 times;meanwhile,the carrier lifetimes of the samples become shorter.Although the processes almost return to their initial state after the pressure release,it is still surprising to see that the carrier mobilities of fewlayer and bulk MoSe2 are still~1.5 and 2 times enhanced,and carrier lifetimes are still shorter than the initial state.Combined with the Raman spectra under pressure,we consider that it is caused by the enhanced layer coupling and lattice compression.The combination of enhanced mobility and shortened lifetime in MoSe_(2) under pressure holds great potential for optoelectronic applications under the deep ocean and deep earth. | Zhiying Bai He Zhang Jiaqi He Dawei He Jiarong Wang Guili Li Jinxuan Bai Kun Zhao Xiaohui Yu Yongsheng Wang Xiaoxian Zhang | 2023 | Nano Research2023，16，11： | 0 |
| 3 | Rapid and sensitive detection of Oncorhynchus mykiss adulteration in Salmo salar by recombinase polymerase amplification combined with lateral flow strip显示文摘Oncorhynchus mykiss,a kind of freshwater fish,belongs to the Salmonidae family and Oncorhynchus genus[1].O.mykiss is farmed in more than 20 cities in China,being one of the most common cold-water farming fish.The wide range of O.mykiss may attribute to its rapid growth and tolerance of different environmental conditions.Salmo salar attracts customers’interest for its delicious taste and high nutrient contents.However,wild S.salar supply is far less than high demands,and artificial breeding faces difficulties in yield and cost.External morphological characteristics can distinguish full-fledged fish,but it is difficult to distinguish after processing with pigments for the white and blue O.mykiss meat displaying orange color and texture[2].The food industry provides cheaper O.mykiss adulteration in S.salar,infringing consumers’rights and interests.Moreover,farmed O.mykiss in fresh water may risk parasite infection,and customers who eat raw food face food safety concerns[3]. | Qiankun Yang Xia Liu Lei Wang Guili Yu Haitao Yang Hang Fu Xueqing Li Nana He Hong Yu Jingquan Dong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 0 |
| 4 | An efficient and globally optimal solution to perspective-n-line problem显示文摘This research develops an accurate and efficient method for the Perspective-n-Line(Pn L)problem. The developed method addresses and solves Pn L via exploiting the problem’s geometry in a non-linear least squares fashion. Specifically, by representing the rotation matrix with a novel quaternion parameterization, the Pn L problem is first decomposed into four independent subproblems. Then, each subproblem is reformulated as an unconstrained minimization problem, in which the Kronecker product is adopted to write the cost function in a more compact form. Finally, the Groobner basis technique is used to solve the polynomial system derived from the first-order optimality conditions of the cost function. Moreover, a novel strategy is presented to improve the efficiency of the algorithm. It is improved by exploiting structure information embedded in the rotation parameterization to accelerate the computing of coefficient matrix of a cost function. Experiments on synthetic data and real images show that the developed method is comparable to or better than state-of-the-art methods in accuracy, but with reduced computational requirements. | Qida YU Guili XU Zhengsheng WANG Zhenhua LI | 2022 | Chinese Journal of Aeronautics2022，35，3： | 0 |
| 5 | NLRP3 inflammasome signal pathway involves in Vibrio harveyi-induced inflammatory response in murine peritoneal macrophages in vitro显示文摘Vibrio harveyi,an important zoonotic pathogen,can infect wounds and cause inflammatory response.Understanding the inflammatory response pathways could facilitate the exploration of molecular mechanisms for treating V.harveyi infection.NLR family pyrin domain-containing 3(NLRP3)inflammasome is involved in the interaction between hosts&pathogenic microorganisms&could be sensed by various pathogen-associated molecular patterns(PAMPs)or damage-associated molecular patterns(DAMPs).Nonetheless,the function of NLRP3 inflammasome in V.harveyi infection remains unclear.In the present study,we established a V.harveyi infection model using murine peritoneal macrophages(PMs).Various techniques,including western blot analysis,enzyme-linked immunosorbent assay(ELISA),RT-qPCR,immunofluorescence,&inhibition assays,were used to explore the molecular mechanism of V.harveyi-induced inflammation.The results showed that many inflammatory cytokines participated in V.harveyi infection,with interleukin(IL)-1βbeing the most abundant.Pan-caspase inhibitor pretreatment significantly decreased the secretion of IL-1βin murine PMs.Moreover,the identification of V.harveyi involved a large number of NLR molecules,especially the NLRP3 receptor,&further studies revealed that NLPR3 inflammasome was activated by V.harveyi infection,as evidenced by puncta-like NLRP3 surrounding cell nuclear,ASC specks in the nucleus&cytoplasm,&ASC oligomerization.Inhibition of NLRP3 inflammasome impaired the release of mature IL-1βin V.harveyi-infected murine PMs.Furthermore,blocking the secretion of mature IL-1βcould markedly decrease the release of other proinflammatory cytokines,including IL-6,IL-12,&tumor necrosis factor-α.Overall,these data indicated that NLRP3 inflammasome was activated in response to V.harveyi infection and enhanced inflammatory response by promoting IL-1βsecretion in murine PMs. | Guili Yu Jinxin Wang Wei Zhang Qiankun Yang Gang Liu Lei Wang Babatunde Kazeem Bello Xiao Zhang Tianmeng Zhang Hui Fan Panpan Zhao Wei Liang Jingquan Dong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 0 |
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