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| 1 | PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives显示文摘Cervical cancer (CC) is the fourth most commonly diagnosed female malignancy and a leading cause of cancer-related mortality worldwide, especially in developing countries. Despite the use of advanced screening and preventive vaccines, more than half of all CC cases are diagnosed at advanced stages, when therapeutic options are extremely limited and side effects are severe. Given these circumstances, new and effective treatments are needed. In recent years, exciting progress has been made in immunotherapies, including the rapid development of immune checkpoint inhibitors. Checkpoint blockades targeting the PD-1/PD-L1 axis have achieved effective clinical responses with acceptable toxicity by suppressing tumor progression and improving survival in several tumor types. In this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway, including the expression patterns of PD-1/PD-L1 and potential PD-l/PD-Ll-related therapeutic strategies for CC. | Yumeng Wang Guiling Li | 2019 | Frontiers of Medicine2019，13，4： | 17 |
| 2 | Research on Formation Mechanisms of Hot Dry Rock Resources in China显示文摘As an important geothermal resource, hot dry rock(HDR) reserves have been studied in many countries. HDR resources in China have huge capacity and have become one of the most important resources for the potential replacement of fossil fuels. However, HDR resources are difficult to develop and utilise. Technologies for use with HDR, such as high–temperature drilling, reservoir characterisation, reservoir fracturing, microseismic monitoring and high–temperature power stations, originate from the field of oil and drilling. Addressing how to take advantage of these developed technologies is a key factor in the development of HDR reserves. Based on the thermal crustal structure in China, HDR resources can be divided into four types: high radioactive heat production, sedimentary basin, modern volcano and the inner–plate active tectonic belt. The prospective regions of HDR resources are located in South Tibet, West Yunnan, the southeast coast of China, Bohai Rim, Songliao Basin and Guanzhong Basin. The related essential technologies are relatively mature, and the prospect of HDR power generation is promising. Therefore, analysing the formation mechanisms of HDR resources and promoting the transformation of technological achievements, large–scale development and the utilisation of HDR resources can be achieved in China. | WANG Guiling LIN Wenjing ZHANG Wei LU Chuan MA Feng GAN Haonan | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 14 |
| 3 | Fault plane parameters of Sanhe-Pinggu M8 earthquake in 1679 determined using present-day small earthquakes显示文摘The great Sanhe-Pinggu M8 earthquake occurred in 1679 was the largest surface rupture event recorded in history in the northern part of North China plain. This study determines the fault geometry of this earthquake by inverting seismological data of present-day moderate-small earthquakes in the focal area. We relocated those earthquakes with the double-difference method.Based on the assumption that clustered small earthquakes often occur in the vicinity of fault plane of large earthquake, and referring to the morphology of the long axis of the isoseismal line obtained by the predecessors, we selected a strip-shaped zone from the relocated earthquake catalog in the period from 1980 to 2009 to invert fault plane parameters of this earthquake. The inversion results are as follows: the strike is 38.23°, the dip angle is 82.54°,the slip angle is-156.08°, the fault length is about 80 km,the lower-boundary depth is about 23 km and the buried depth of upper boundary is about 3 km. This shows that the seismogenic fault is a NNE-trending normal dip-slip fault,southeast wall downward and northwest wall uplift, with the right-lateral strike-slip component. Moreover, the surface rupture zone, intensity distribution of the earthquake and seismic-wave velocity profile in the focal area all verified our study result. | Xiaoshan Wang Xiangdong Feng Xiwei Xu Guiling Diao Yongge Wan Libin Wang Guangqing Ma | 2014 | Earthquake Science2014，27，6： | 9 |
| 4 | Clinical study of paclitaxel plus cisplatin in the treatment of recurrent cervical cancer显示文摘Objective: To observe the efficacy and toxicities of paclitaxel plus cisplatin in the treatment of recurrent cervical cancer. Methods: Twenty-three patients with a diagnosis of recurrent cervical cancer were eligible. Three-weekly chemo- therapy regimen consisted of paclitaxel 135–150 mg/m2 infusion for 3 h on day 1, cisplatin 25 mg/m2 infusion on day 1 to 3. All patients received at least two cycles treatment. Results: The response rates was 47.8%, including CR 2 cases (8.7%), PR 9 cases (39.1%). The major toxicity included neutropenia, nausea vomiting, arthralgia, myalgia and alopecia. Conclusion: Paclitaxel combined with cisplatin is an effective therapy with acceptable adverse reactions for recurrent cervical cancer. | Yingqiu Song Guiling Li Fang Zhu Fangzheng Zhou Sheng Zhang Jing Wang Zhongyuan Ying | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 9 |
| 5 | How Does the Partitioning of Evapotranspiration and Runoff between Different Processes Affect the Variability and Predictability of Soil Moisture and Precipitation?显示文摘Water stored as part of the land surface is lost to evapotranspiration and runoff on different time scales,and the partitioning between these time scales is important for modeling soil water in a climate model.Different time scales are imposed on evapotranspiration primarily because it is derived from differentreservoirs with different storage capacities, from the very rapid evaporation of canopy stores to the slowremoval by transpiration of rooting zone soil moisture. Runoff likewise ranges in time scale from rapidsurface terms to the slower base-flow. The longest time scale losses of water determine the slow variationof soil moisture and hence the longer time scale effects of soil moisture on precipitation. This paper showswith a simple analysis how shifting the partitioning of evapotranspiration between the different reservoirsaffects the variability of soil moisture and precipitation. In particular, it is concluded that a shift toshorter time scale reservoirs shifts the variance of precipitation from that which is potentially predictableto unpredictable. | Robert E.Dickinson Guiling WANG Xubin Zeng 曾庆存 | 2003 | Advances in Atmospheric Sciences2003，20，3： | 9 |
| 6 | Isolation of Tyl-copia-like Retrotransposon Sequences from the Apple Genome by Chromosome Walking Based on Modified SiteFinding-polymerase Chain Reaction显示文摘长终端重复(LTR ) retrotransposons 是为学习基因生物多样性,染色体进化,基因变化,克隆的基因和基因表达的强大的工具。缺乏 ofretrotransposon 顺序信息限制在在场的更高的 plants.Inthe 的研究学习的这些的发展, Ty1-copia-like retrotransposons 的 31 逆[转]录酶( RT )基因被放大编码区域使用的 RT 从苹果染色体识别 degenerateprimers.Nineteen RT 基因以碎片尺寸显示出极端异质,基础对作文和开的读框架完全。从一 266 bp 发源克隆 RT 基因, 1966 bpTy1-copia-like retrotransposon (命名 Tcrm1 )包括 RT-ribonuclease H-LTR 领域序列,被染色体在基因结构和 Tcrml 是包括在揭示的 applegenome.Dot 污点分析的一个 LTR 领域的第一 Ty1-copia-like retrotransposon 的顺序相同 hows 基于在 Tcrml 和另外的 LTR retrotransposons 之间的修改SiteFinding聚合酶链 reaction.Thecomparison 走完成在苹果的那个 Tcrm1 拷贝数字每 haploid 是近似 1x10 ~ 3copies 染色体。 | Guiling ZHAO Zhihong ZHANG Haiyue SUN He LI Hongyan DAI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 8 |
| 7 | Genomic insights into the fast growth of paulownias and the formation of Paulownia witches' broom显示文摘Paulownias are among the fastest growing trees in the world,but they often suffer tremendous loss of wood production due to infection by Paulownia witches'broom(PaWB)phytoplasmas.In this study,we have sequenced and assembled a high-quality nuclear genome of Paulownia fortunei,a commonly cultivated paulownia species.The assembled genome of P.fortunei is 511.6 Mb in size,with 93.2%of its sequences anchored to 20 pseudo-chromosomes,and it contains 31985 protein-coding genes.Phylogenomic analyses show that the family Paulowniaceae is sister to a clade composed of Phrymaceae and Orobanchaceae.Higher photosynthetic efficiency is achieved by integrating C3 photosynthesis and the crassulacean acid metabolism pathway,which may contribute to the extremely fast growth habit of paulownia trees.Comparative transcriptome analyses reveal modules related to cambial growth and development,photosynthesis,and defense responses.Additional genome sequencing of PaWB phytoplasma,combined with functional analyses,indicates that the effector PaWB-SAP54 interacts directly with Paulownia PfSPLa,which in turn causes the degradation of PfSPLa by the ubiquitin-mediated pathway and leads to the formation of witches'broom.Taken together,these results provide significant insights into the biology of paulownias and the regulatory mechanism for the formation of PaWB. | Yabing Cao Guiling Sun Xiaoqiao Zhai Pingluo Xu Liming Ma Minjie Deng Zhenli Zhao Haibo Yang Yanpeng Dong Zhonghai Shang Yujie Lv Lijun Yan Haifang Liu Xibing Cao Bingbing Li Zhe Wang Xiaogai Zhao Haiyan Yu Fan Wang Wen Ma Jinling Huang Guoqiang Fan | 2021 | Molecular Plant2021，14，10： | 7 |
| 8 | Fault plane parameters of Tancheng M81/2 earthquake on the basis of present-day seismological data显示文摘The great Tancheng earthquake of M81/2 occurred in 1668 was the largest seismic event ever recorded in history in eastern China.This study determines the fault geometry of this earthquake by inverting seismological data of present-day moderate-small earthquakes in the focal area.We relocated those earthquakes with the double-difference method and found focal mechanism solutions using gird test method.The inversion results are as follows:the strike is 21.6°,the dip angle is 89.5°,the slip angle is 170°,the fault length is about 160 km,the lower-boundary depth is about 32 km and the buried depth of upper boundary is about 4 km.This shows that the seismic fault is a NNE-trending upright right-lateral strike-slip fault and has cut through the crust.Moreover,the surface seismic fault,intensity distribution of the earthquake,earthquake-depth distribution and seismic-wave velocity profile in the focal area all verified our study result. | Cuiying Zhou Guiling Diao Jie Geng Yonghong Li Ping Xu Xinliang Hu Xiangdong Feng | 2010 | Earthquake Science2010，23，6： | 7 |
| 9 | Nitrogen and Phosphorus Dual-Doped Multilayer Graphene as Universal Anode for Full Carbon-Based Lithium and Potassium Ion Capacitors显示文摘Lithium/potassium ion capacitors(LICs/PICs) have been proposed to bridge the performance gap between high-energy batteries and high-power capacitors.However,their development is hindered by the choice,electrochemical performance,and preparation technique of the battery-type anode materials.Herein,a nitrogen and phosphorus dual-doped multilayer graphene(NPG) material is designed and synthesized through an arc discharge process,using low-cost graphite and solid nitrogen and phosphorus sources.When employed as the anode material,NPG exhibits high capacity,remarkable rate capability,and stable cycling performance in both lithium and potassium ion batteries.This excellent electrochemical performance is ascribed to the synergistic effect of nitrogen and phosphorus doping,which enhances the electrochemical conductivity,provides a higher number of ion storage sites,and leads to increased interlayer spacing.Full carbon-based NPG‖LiPF6‖active carbon(AC) LICs and NPG‖KPF6‖AC PICs are assembled and show excellent electrochemical performance,with competitive energy and power densities.This work provides a route for the large-scale production of dual-doped graphene as a universal anode material for high-performance alkali ion batteries and capacitors. | Yuting Luan Rong Hu Yongzheng Fang Kai Zhu Kui Cheng Jun Yan Ke Ye Guiling Wang Dianxue Cao | 2019 | Nano-Micro Letters2019，11，2： | 6 |
| 10 | Electrostatic self-assembly of MXene and edge-rich CoAl layered double hydroxide on molecular-scale with superhigh volumetric performances显示文摘It is highly desirable to design and synthesize two-dimensional nanostructured electrode materials with high electrical conductivity,large electrolyte-accessible surface area and more exposed active sites for energy storage applications.Herein,MXene/Co Al-LDH heterostructure has been prepared through electrostatic ordered hetero-assembly of monolayer MXene and edge-rich Co Al-LDH nanosheets in a faceto-face manner on molecular-scale for supercapacitor applications.Benefiting from the unique structure,strong interfacial interaction and synergistic effects between MXene and Co Al-LDH nanosheets,the electrical conductivity and exposed electrolyte-accessible active sites are significantly enhanced.The asprepared MXene/Co Al-LDH-80%(ML-80)film exhibits high volumetric capacity of 2472 C cm-3 in 3 M KOH electrolyte with high rate capability of 70.6%at 20 A g-1.Notably,to the best of our knowledge,the high volumetric capacity is the highest among other previously reported values for supercapacitors in aqueous electrolytes.Furthermore,our asymmetric supercapacitor device fabricated with ML-80 and MXene/graphene composite as cathode and anode,respectively,exhibits impressive volumetric energy density of 85.4 Wh L-1 with impressive cycling stability of 94.4%retention ratio after 30,000 continuous charge/discharge cycles. | Hao Niu Xue Yang Qian Wang Xiaoyan Jing Kui Cheng Kai Zhu Ke Ye Guiling Wang Dianxue Cao Jun Yan | 2020 | Journal of Energy Chemistry2020，29，7： | 6 |
| 11 | Progress in electrochemical lithium ion pumping for lithium recovery显示文摘Accelerating the development of lithium resources has attracted a great deal of attention with the explosive growth of new energy vehicles.As a new technology,electrochemical lithium ion pumping(ELIP)is featured by environment-friendly,low energy consumption and high efficiency.This review summarizes the research progress in ELIP,and focuses on the evaluation methods,electrode materials and electrochemical systems of ELIP.It can be concluded that ELIP is expected to achieve an industrial application and has a promising prospect.In addition,challenges and perspective of electrochemical lithium extraction are also highlighted. | Guolang Zhou Linlin Chen Yanhong Chao Xiaowei Li Guiling Luo Wenshuai Zhu | 2021 | Journal of Energy Chemistry2021，30，8： | 6 |
| 12 | Ultrahigh energy density battery-type asymmetric supercapacitors: NiMoO4 nanorod-decorated graphene and graphene/Fe2O3 quantum dots显示文摘 | Jiao Yang Wei Liu Hao Niu Kui Cheng Ke Ye Kai Zhu Guiling Wang Dianxue Cao Jun Yan | 2018 | Nano Research2018，11，9： | 5 |
| 13 | Fracture Characteristics and Heat Accumulation of Jixianian Carbonate Reservoirs in the Rongcheng Geothermal Field, Xiong'an New Area显示文摘Geothermal energy plays an important role in urban construction of the Xiong’an New Area. Geothermal reservoir fracture distribution of the Mesoproterozoic Jixianian Wumishan Formation(Fm.) carbonate reservoir in the Rongcheng geothermal field are evaluated based on FMI log from Wells D19 and D21. The results show carbonate reservoir fracture density of Well D19 is 15.2/100 m, greater than that of Well D21 with a value of 9.2/100 m. Reservoir porosity and permeability of Well D19 are better than that of Well D21, and the water saturation is bimodally distributed. The movable fluid volume ratio(BVM) of Well D19 is 2% to 8% with some zones exceeding 20%, while the value of Well D21 is less than 4%. Therefore, reservoir fractures in Well D19 are more conducive to fluid flow. Reservoir fractures have a similar occurrence to normal faults, indicating that the tensile stress field controlled the formation of such fractures. Developed reservoir fractures provide a good channel for groundwater convection. The circulation of regional groundwater and the heat exchange between water and rock and the multiple heat accumulation patterns form a stable and high potential heat reservoir in the Rongcheng geothermal field. | WANG Yingjin MA Feng XIE Heping WANG Guiling WANG Zhihe | 2021 | Acta Geologica Sinica(English Edition)2021，95，6： | 5 |
| 14 | Uniformly grown PtCo-modified C03O4 nanosheets as a highly efficient catalyst for sodium borohydride electrooxidation显示文摘 | Congying Song Dongming Zhang Bin Wang Zhuang Cai Peng Yan Yang Sun Ke Ye Dianxue Cao Kui Cheng Guiling Wang | 2016 | Nano Research2016，9，11： | 5 |
| 15 | Heat Aggregation Mechanisms of Hot Dry Rocks Resources in the Gonghe Basin, Northeastern Tibetan Plateau显示文摘Hot dry rock(HDR) is an important geothermal resource and clean energy source that may play an increasingly important role in future energy management. High-temperature HDR resources were recently detected in deep regions of the Gonghe Basin on the northeastern edge of the Tibetan Plateau, which led to a significant breakthrough in HDR resource exploration in China. This research analyzes the deep temperature distribution, radiogenic heat production, heat flow, and crustal thermal structure in the Qiaboqia Valley, Guide Plain, and Zhacanggou area of the Gonghe Basin based on geothermal exploration borehole logging data, rock thermophysical properties, and regional geophysical exploration data. The results are applied to discuss the heat accumulation mechanism of the HDR resources in the Gonghe Basin. The findings suggest that a low-velocity layer in the thickened crust of the Tibetan Plateau provides the most important source of constant intracrustal heat for the formation of HDR resources in the Gonghe Basin, whereas crustal thickening redistributes the concentrated layer of radioactive elements, which compensates for the relatively low heat production of the basal granite and serves as an important supplement to the heat of the HDR resources. The negative effect is that the downward curvature of the lithospheric upper mantle caused by crustal thickening leads to a small mantle heat flow component. As a result, the heat flows in the Qiaboqia Valley and Guide Plain of the Gonghe Basin are 106.2 and 77.6 m W/m2, respectively, in which the crust-mantle heat flow ratio of the former is 3.12:1, indicating a notably anomalous intracrustal thermal structure. In contrast, the crust-mantle heat flow ratio in the Guide Plain is 1.84:1, which reflects a typical hot crust-cold mantle thermal structure. The Guide Plain and Zhacanggou area show the same increasing temperature trend with depth, which reflects that their geothermal backgrounds and deep high-temperature environments are similar. These results provide important insight on the heat source mechanism of HDR resource formation in the Tibetan Plateau and useful guidance for future HDR resource exploration projects and target sites selection in similar areas. | LIN Wenjing WANG Guiling ZHANG Shengsheng ZHAO Zhen XING Linxiao GAN Haonan TAN Xianfeng | 2021 | Acta Geologica Sinica(English Edition)2021，95，6： | 5 |
| 16 | Quantifying the Preferential Flow by Dye Tracer in the North China Plain显示文摘The preferential flow plays a vital role on the infiltration of irrigation or rainfall. The objective of this study was to quantify preferential flow in the processing of irrigation infiltration in the field scale. Tests of different initial soil water contents and irrigation intensities were conducted using Brilliant Blue FCF(C.I.42090) dye tracer in Luancheng County of the North China Plain. The results showed that the percentages of infiltration by the preferential flow for irrigation depth of 25, 50, and 75 mm were 16.67%, 43.67%, and 34.17%, with 19.72%, 61.42%, 66.64% of dyed areas in the soil profile, respectively, which indicated that preferential flow was enhanced with increasing irrigation intensity, but reduced when the irrigation intensity was over 50 mm. The percentages of preferential flow for 75 and 180 mm previous irrigation producing different initial soil water contents were 23.26% and 18.97%, with 53.23% and 39.94% of dyed areas in the soil profile, respectively. Compared with the 75 mm without previous irrigation, the results indicated that higher initial soil water contents restrained the preferential flow in the field. Therefore, intermittent irrigation and low irrigation intensity patterns, and larger depth of plowing would be suggested to reduce the preferential flow which would increase the soil water utilization efficiency and reduce pollution risk of pesticide and fertilizer to groundwater. | Qinghua Wu Chunlei Liu Wenjing Lin Meng Zhang Guiling Wang Fawang Zhang | 2015 | Journal of Earth Science2015，26，3： | 4 |
| 17 | A New Method with High Confidence for Validation of Computer Simulation Models of Flight Systems显示文摘Computer simulation models may by used to gain further information about missile performance variability. Model validation is an important aspect of the test program for a missile system. Validation provides a basis for confidence in the model’s results and is a necessary step if the model is to be used to draw inference about the behavior of the real missile. This paper is a review of methods useful for validation of computer simulation models of missile systems and provides a new method with high degree of confidence for validation of computer simulation models of missile systems. Some examples of the use of the new method in validating computer simulation models are given. | Zhou XianminShanghai Research & Development Centre, 412 Guil in Road, Shanghai 200233, P.R.China | 1993 | Journal of Systems Engineering and Electronics1993，4，4： | 4 |
| 18 | FE Analysis of Longitudinal Dynamic Response of Subgrade in Bridge-Subgrade Transition of Heavy Haul Railway显示文摘 | Shengchuan Liu Guiling Ding Lianjun Wang Jianguo Chen | 2010 | Journal of Civil Engineering and Architecture2010，4，5： | 4 |
| 19 | Cycling of phosphorus in the Jiaozhou Bay显示文摘Dissolved inorganic phosphorus (DIP ),dissolved organic phosphorus (DOP ),particulate inorganic phosphorus (P IP ) and particulate organic phosphorus (P OP ) in the Jiaozhou Bay (JZB) and its adjacent major rivers were analyzed during 2001–2003.DIP was the major form of dissolved phosphorus in JZB,representing 62%–83% of the total dissolved phosphorus (T DP ),and the P IP concentration generally exceeded the P OP concentration.The concentrations of phosphorus were higher in the north than in the south of the bay,which were related to the fluvial input and water exchange rate.The dissolved phosphorus concentrations were higher in the autumn and spring than in the summer,while the seasonal variation of particulate phosphorus showed opposite pattern.The distribution of phosphorus is mainly affected by the growth of phytoplankton,desorption/adsorption of DIP from and to particulates,and anthropogenic activities.A preliminary phosphorus budget was established.In JZB,riverine input and water exchange flow between JZB and the Huanghai (Yellow) Sea are the major sources of phosphorus,followed by industrial and domestic waste transport,and then atmospheric deposition.Phosphorus burial efficiency is estimated to be 91%.About 52.2 × 10 6 mol/a of phosphorus were assimilated by phytoplankton,of which about 68% was recycled in the water column and sediment. | Q1 Xiaohong LIU Sumei ZHANG Jing REN Jingling ZHANG Guiling | 2011 | Acta Oceanologica Sinica2011，30，2： | 4 |
| 20 | Genome-wide identification of agronomically important genes in outcrossing crops using OutcrossSeq显示文摘Many important crops(e.g.,tuber,root,and tree crops)are cross-pollinating.For these crops,no inbred lines are available for genetic study and breeding because they are self-incompatible,clonally propagated,or have a long generation time,making the identification of agronomically important genes difficult,particularly in crops with a complex autopolyploid genome.In this study,we developed a method,OutcrossSeq,for mapping agronomically important loci in outcrossing crops based on whole-genome low-coverage resequencing of a large genetic population,and designed three computation algorithms in OutcrossSeq for different types of outcrossing populations.We applied OutcrossSeq to a tuberous root crop(sweet potato,autopolyploid),a tree crop(walnut tree,highly heterozygous diploid),and hybrid crops(double-cross populations)to generate high-density genotype maps for the outcrossing populations,which enable precise identification of genomic loci underlying important agronomic traits.Candidate causative genes at these loci were detected based on functional clues.Taken together,our results indicate that OutcrossSeq is a robust and powerful method for identifying agronomically important genes in heterozygous species,including polyploids,in a cost-efficient way.The OutcrossSeq software and its instruction manual are available for downloading at www.xhhuanglab.cn/tool/OutcrossSeq.html. | Mengjiao Chen Weijuan Fan Feiyang Ji Hua Hua Jie Liu Mengxiao Yan Qingguo Ma Jiongjiong Fan Qin Wang Shufeng Zhang Guiling Liu Zhe Sun Changgeng Tian Fengling Zhao Jianli Zheng Qi Zhang Jiaxin Chen Jie Qiu Xin Wei Ziru Chen Peng Zhang Dong Pei Jun Yang Xuehui Huang | 2021 | Molecular Plant2021，14，4： | 4 |
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