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| 1 | Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes显示文摘AIM To detect human papilloma virus(HPV) presence and to characterize cellular immune response in breast cancer patients. METHODS A total of 74 women were included, of which 48 samples were from patients diagnosed with breast cancer and 26 patients with benign pathology of the breast. Molecular subtype classification was performed based on the immunohistochemical reports of the tumor piece. HPV genome detection and genotyping from fresh breast biopsies was performed using the INNO-LIPA HPV Genotyping Extra test(Innogenetics, Ghent, Belgium). CD3+, CD4+, CD8+ and natural killer(NK)+ cells levels from peripheral blood samples from patients with breast cancer and benign pathology were measured by flow cytometry. RESULTS Luminal A was the most frequent breast cancer molecular subtype(33.33%). HPV was detected in 25% of the breast cancer patients, and genotype 18 was the most frequent in the studied population. The mean of CD3+, CD4+ and CD8+ subpopulations were decreased in patients with breast cancer, in relation to those with benign pathology, with a statistically significant difference in CD8+ values(P = 0.048). The mean of NK+ cells was increased in the benign pathology group. The average level of CD3+, CD4+, CD8+ and NK+ cells decreased as the disease progressed. HER2+ and Luminal B HER2+ tumors had the lowest counts of cell subsets. HPV breast cancer patients had elevated counts of cellular subsets. CONCLUSION Determining level changes in cellular subsets in breast cancer patients is a useful tool to evaluate treatment response. | Andreína Fernandes Adriana Pesci-Feltri Isabel García-Fleury Marco López Vincent Guida Marisol De Macedo María Correnti | 2018 | World Journal of Clinical Oncology2018，9，7： | 5 |
| 2 | Nasal nitric oxide concentration in suspected chronic rhinosinusitis显示文摘 | Bommarito L Guida G Hef tier E | 2008 | Ann Allergy Asthma Immunol2008，101，4： | 1 |
| 3 | Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor显示文摘 | Wu Y Sun H Basta-Pljakic J Cardoso L Kennedy OD Jasper H Domene H Karabatas L Guida C Schaffler MB Rosen CJ Yakar S | | 0，，： | 1 |
| 4 | Laparoscopic or open hemicolectomy for elderly patients with right colon cancer A retrospective analysis显示文摘 | Guida F Clemente M Valvano L | 2015 | G Chir2015，36，5： | 1 |
| 5 | Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis显示文摘 | MAGNONE M BRUZZONE S GUIDA L | 2009 | J Biol Chem2009，284，17： | 1 |
| 6 | Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants 显示文摘 | Guida T Anaganti S Provitera L | 2007 | Clin Cancer Res2007，13，： | 1 |
| 7 | Nasal nitric oxide concentration in suspected chronic rhinosinusitis 显示文摘 | Bommarito L Guida G Heftier E | 2008 | Ann Allergy Asthma Immunol2008，101，4： | 1 |
| 8 | Acetylsalicylic acid inhibits proliferation of human bone marrow stromal cells and matrix mineralization 显示文摘 | Guida L Annunziata M Passaro I | 2008 | lnt J lmmunopathol Pharmacol2008，21，4： | 1 |
| 9 | In vitro and in vivo effects of cefodizime and ceftriaxone on oxygen-dependent killing of neutrophils of elderly patients with exacerbation of chronic bronchitis显示文摘 | Papa L Guida G Morano CM | 1996 | Infez Med1996，4，4： | 1 |
| 10 | Increased exhaled nitric oxide in obstructive sleep apnoea 显示文摘 | Culla B Guida G Brussino L | 2010 | Respir Med2010，104，： | 1 |
| 11 | Newly characterised 5' and 3' regions of CACNA1A gone harbour mutations associated with familial hemiplegic migraine and episodic ataxia 显示文摘 | Veneziano L Guida S Mantnano E | 2009 | J Neurol Sci2009，276，12： | 1 |
| 12 | LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells显示文摘 | Sturla L Fresia C Guida L | 2009 | The Journal of Biological Chemis- try2009，284，28： | 1 |
| 13 | RET is a heat shock protein 90 (HSP90) client protein and is knocked down upon HSP90 pharmacological block显示文摘 | Alfano L Guida T Provitera L | 2010 | J Clin Endocrinol Metab2010，95，7： | 1 |
| 14 | Reliability of DHPLC in mutational screening of b-globin (HBB) alleles显示文摘 | COLOSIMO A GUIDA V DE L A et ol | 2002 | Human Mutation2002，19，： | 1 |
| 15 | RET is a heat shock protein 90 (HSP90) chient protein and is knocked down upon HSP90 pharma- cological block显示文摘 | A|fano L Guida T Provitera L et a/ | 2010 | J Clin Endocrinol Metub2010，95，4： | 1 |
| 16 | Perfor- mance of polymerase chain reaction analysis of the amni- otic fluid of pregnant women for diagnosis of congenital toxoplasmosis:A systematic review and Meta-analysis显示文摘 | Oliveira Azevedo CT Brasil PE Guida L | 2016 | PLoS One2016，11，4： | 1 |
| 17 | Cryptosporidium parvum:PCR-RFLP anslysis of the TRAP-C1(Thrombospondium-Related Adhensive Protein of Cryptosporidium-C1) gene discriminates between two alleles differentically associated with parasite isolates of animal and human origin显示文摘 | Spano F Putignani L Guida S | 1998 | Exp Parasitol1998，90，2： | 1 |
| 18 | LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells显示文摘 | STURLA L FRESIA C GUIDA L | 2009 | Journal of Biological Chemistry2009，284，28： | 1 |
| 19 | Cryptosporidium parvum:PCR-RFLP analysis of the TRAP-C1 (thrombospondin-related adhesive protein of Cryptosporidiurn-1) gene discriminates between two alleles differentially associated with parasite isolates of animal and human origin显示文摘 | Spano F Putignani L Guida S et at | 1988 | Exp Parasitol1988，90，： | 1 |
| 20 | Human gingival fibro- blast functions are stimulated by oxidized nano-structnred titanium surfaces显示文摘 | Guida L Oliva A Basile MA | 2013 | J Dent2013，41，10： | 1 |
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