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| 1 | Cd3(C3N3S3)2 coordination polymer/graphene nanoarchitectures for enhanced photocatalytic H2O2 production under visible light显示文摘For a long time, there has been global concern over the environment and energy problems. Recently, the problems, which have brought about serious effect on the global living condition, have been in the ‘‘spotlight' and given impetus to the universal's efforts to head for the same direction: stem the worst warming and strive for the renewable energy source. Hydrogen peroxide(H_2O_2) is undoubtedly a good choice,which holds the promise as a clean, efficient, safe and transferrable energy carrier. Octahedral coordination polymer, Cd_3(C_3N_3S_3)_2, was found to be a robust photocatalyst for H_2O_2 generation under visible light irradiation. To further improve the H_2O_2 generation efficiency, adhering the octahedron to reduced graphene(rGO) was applied as the strategy herein. The study shows that by adhering Cd_3(C_3N_3S_3)_2to rGO, the formation of H_2O_2 is 2.5-fold enhanced and its deformation is concurrently suppressed. This work not only demonstrates the effectiveness of adhering Cd_3(C_3N_3S_3)_2polymer to rGO for the improvement of the polymer's photocatalytic performance, but also proposes a general way for the fabrication of graphene/coordination compound hybrids for maximizing their synergy. | Jie Xu Zhenye Chen Hongwen Zhang Guibin Lin Huaxiang Lin Xuxu Wang Jinlin Long | 2017 | Science Bulletin2017，62，9： | 4 |
| 2 | An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing显示文摘Moderately regulating vascularization and immune microenvironment of wound site is necessary to achieve scarless wound healing of the skin.Herein,we have prepared an angiogenesis-promoting and scar-preventing band-aid with a core-shell structure,that consists of MXene-loaded nanofibers(MNFs)as the core and dopamine-hyaluronic acid hydrogel(H)as the shell(MNFs@V-H@DA)to encapsulate a growth factor(vascular endothelial growth factor,VEGF,abbreviated as V)and H2S donor(diallyl trisulfide,DATS,abbreviated as DA).The continuous release of DA from this system produced H2S,which would successfully induce macrophages to polarize into M2-lile phenotype,regulating the immune microenvironment and inhibiting an excessive inflammatory response at the wound sites.It is conducive to the proliferation of skin cells,facilitating the wound healing.In addition,an appropriate amount of VEGF can be released from the MXene nanofibrous skeleton by adjusting the time of near-infrared(NIR)light exposure,preventing excessive neovascularization and extracellular matrix deposition at the wound sites.Collectively,this NIR photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue. | Lin Jin Xiaoqing Guo Di Gao Yan Liu Jiahua Ni Zhiming Zhang Yiqiao Huang Guibin Xu Zhe Yang Xingcai Zhang Xianhan Jiang | 2022 | Bioactive Materials2022，7，10： | 4 |
| 3 | Salivary microbiota may predict the presence of esophageal squamous cell carcinoma显示文摘The aim is to explore the predictive value of salivary bacteria for the presence of esophageal squamous cell carcinoma (ESCC). Saliva samples were obtained from 178 patients with ESCC and 101 healthy controls, and allocated to screening and verification cohorts, respectively. In the screening phase, after saliva DNA was extracted, 16S rRNA V4 regions of salivary bacteria were amplified by polymerase chain reaction (PCR) with high-throughput sequencing. Highly expressed target bacteria were screened by Operational Taxonomic Units clustering, species annotation and microbial diversity assessment. In the verification phase, the expression levels of target bacteria identified in the screening phase were verified by absolute quantitative PCR (Q-PCR). Receiver operating characteristic (ROC) curves were plotted to investigate the predictive value of target salivary bacteria. LEfSe analysis revealed higher proportions of Fusobacterium, Streptococcus and Porphyromonas, and Q-PCR assay showed significantly higher numbers of Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in patients with ESCC, when compared with healthy controls (all P < 0.05). The areas under the ROC curves for Streptococcus salivarius, Fusobacterium nucleatum, Porphyromonas gingivalis and the combination of the three bacteria for predicting patients with ESCC were 69%, 56.5%, 61.8% and 76.4%, respectively. The sensitivities corresponding to cutoff value were 69.3%, 22.7%, 35.2% and 86.4%, respectively, and the matched specificity were 78.4%, 96.1%, 90.2% and 58.8%, respectively. These highly expressed Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in the saliva, alone or in combination, indicate their predictive value for ESCC. | Junmin Wei Ruifeng Li Yanxian Lu Fan Meng Bohong Xian Xiaorong Lai Xiayi Lin Yu Deng Dongyang Yang Huabin Zhang Liangfang Li Xiaosong Ben Guibin Qiao Wanwei Liu Zijun Li | 2022 | Genes & Diseases2022，9，4： | 2 |
| 4 | Mechanism of gold nanoparticle induced simultaneously increased PCR efficiency and specificity显示文摘Gold nanoparticles(AuNPs)have been reported to induce faster heat transfer of polymerase chain reaction(PCR)solution to enhance PCR efficiency.AuNPs can also increase the specificity of PCR by functioning analogously to single-stranded DNA binding protein(SSB).However,the simple structure of AuNPs makes it difficult to determine how AuNPs affect PCR efficiency and specificity.This study aimed to elucidate the effect of AuNPs on PCR efficiency by altering the denaturation times and annealing temperatures.In addition,comparative study of the effect of AuNPs on PCR inhibition caused by two competitive primers allowed investigation of the mechanisms of AuNP-enhanced PCR accuracy.Finally,heat-treated salmon sperm DNA was used to evaluate whether AuNPs could eliminate the inhibitory PCR effect caused by DNA impurities.This study demonstrated that enhanced thermal conductivity by AuNPs was the main mechanism for increased PCR efficiency and specificity.AuNPs promoted efficient double-stranded DNA template unwinding and dissociation between mismatched primers,DNA fragments and template,and enhanced PCR efficiency and specificity simultaneously.Thus,this significant finding suggests the future use of AuNP-assisted PCR in different fields,especially in rapid clinical diagnosis and screening by PCR. | LIN Yan LI Jia YAO Jing LIANG Yong ZHANG Jie ZHOU QunFang JIANG GuiBin | 2013 | Chinese Science Bulletin2013，58，36： | 2 |
| 5 | Decreasing mercury levels in consumer fish over the three decades of increasing mercury emissions in China显示文摘Fish consumption is the primary dietary route of human exposure to methylmercury.It has been well documented that elevated mercury concentration in fish in North America and Europe is linked to anthropogenic mercury emissions.China is the world’s largest producer,consumer,and emitter of mercury,as well as the world’s largest commercial fish producer and consumer.Although mercury pollution in fish in China is currently receiving much attention worldwide,its status remains largely unknown.Here,we conducted a meta-analysis on total mercury concentrations in marine and freshwater fish samples,covering 35,464 samples collected in China over the past 30 years.It is found that,opposite to the increasing emission and documented mercury contamination events,mercury levels in fish have gradually decreased in China over the past 30 years.The results were in sharp contrast to those found in North America and Europe.The mercury concentrations in fish were significantly anticorrelated with the fish catch and fish aquaculture and were inverse to trophic levels.Overfishing and the short lifecycle of aquaculture fish,both reducing the trophic level and the duration of mercury accumulation,were the most likely causes leading to the decline of mercury concentrations found in fish in China. | Hua Zhang Wenxiong Wang Chejen Lin Xinbin Feng Jianbo Shi Guibin Jiang Thorjørn Larssen | 2022 | Eco-Environment & Health2022，1，1： | 2 |
| 6 | Modeling of contact temperatures and their influence on the tribological performance of PEEK and PTFE in a dual-pin-ondisk tribometer显示文摘The direct blending of polyether ether ketone(PEEK)with a solid lubricant such as polytetrafluoroethylene(PTFE)improves its tribological performance,but compromises its outstanding mechanical properties and processability.While these negative effects might be circumvented via the hybrid wear method,the influence of the contact temperature between multiple sliding components acting together is not fully understood.Herein,an analytical temperature model considering the influence of both micro-and macro-thermal behavior is extended to predict the contact temperature of a dual-pin-on-disk hybrid wear system.The interactions between several heat sources are investigated and experimentally verified.The analytical results show that the nominal temperature rise of the shared wear track is determined by the combined effect of the heat generated by both pin components,while the rise in flash temperature at the region in contact with each pin component is dependent upon its individual characteristics and working conditions.Hence,while different temperature peaks can coexist in the shared wear track,the maximum value dominates the performance of the system.For the experimentally investigated PEEK–PTFE–steel hybrid wear system,the formation of tribofilms is blocked,and the hybrid wear system fails,when the peak temperature exceeds the glass transition temperature of both pins due to an increase in applied load. | Zhibin LIN Ting QU Ke ZHANG Qingbin ZHANG Shengdao WANG Guibin WANG Bingzhao GAO Guowei FAN | 2023 | Friction2023，11，4： | 0 |
| 7 | Flower development and sexual dimorphism in Vernicia montana显示文摘The mu oil tree(Vernicia montana Lour.) is a dioecious species, but the genetic mechanisms underlying its phenotypic sexual dimorphism are unclear. In this study, we determined two pivotal phases of sex differentiation of mu oil tree via morphological and histological analyses of unisexual flowers:(Ⅰ) differentiation of male or female primordia to produce staminate flowers(SFs) or transient hermaphrodite flowers(HFs),and(Ⅱ) complete abortion of stamens in transient HFs to generate pistillate flowers(PFs). A total of 1621 sex-biased genes were identified by comparative transcriptome analysis which exhibited elevated rates of protein evolution than unbiased genes. The female-biased genes were enriched in the production of defense compounds while male-biased genes were focused on the production of viable pollens. Transcriptomebased analysis revealed that the differentially expressed genes(DEGs) between PFs and SFs in phase Ⅰ involved in abscisic acid(ABA), auxin(AUX), cytokinin(CK), ethylene(ET), and gibberellin(GA) biosynthesis and signaling showed higher expression levels in males than in females in general, whereas the DEGs involved in jasmonic acid(JA) and salicylic acid(SA) pathways displayed opposite expression patterns. Moreover,differentially expressed endogenous ABA, AUX, GAs, JA, and SA exhibited consistent biased expression patterns with the DEGs by UPLC-MSbased analysis. Exogenous application of an anti-ethylene plant growth regulator could promote the development of stamens in PFs and generated HFs. Comparative transcriptomic and hormonal analyses of PFs and SFs in phase Ⅱ indicated an increase in ET concentration when abortion of stamens in PFs occurred. This study suggested that phytohormones play key roles in sex dimorphism and ET may determine the development of stamens in PFs of mu oil tree, which provides an insight into plant sex differentiation mechanisms. | Wenying Li Jingzhen Chen Xiang Dong Meilan Liu Guibin Wang Lin Zhang | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 8 | Systemic delivery of gemcitabine analogue and STAT3 siRNA promotes antitumor immunity against melanoma显示文摘Immunosuppressive myeloid cells in the tumor microenvironment(TME)inhibit T-cell-mediated immune response and promote tumor progression.Therapeutically targeting both tumor cells and myeloid cells such as myeloid-derived suppressor cells(MDSCs),is expected to promote antitumor immunity.Gemcitabine(Gem)can serve as a chemotherapeutic drug and a MDSCdepleting agent.Aberrant activation of STAT3 promotes tumor cell growth and orchestrates the immunosuppressive activity of tumor-associated myeloid cells.Here we describe a strategy to kill tumor cells as well as inhibit the expansion and suppressive function of myeloid cells through the systemic delivery of gemcitabine monophosphate(GMP)and STAT3 siRNA(siSTAT3).To enhance their in vivo delivery efficiency,we formulate GMP and siSTAT3 into a lipid-coated calcium phosphate(LCP)nanoparticle and a liposome-protamine-hyaluronic acid(LPH)nanoparticle,respectively.Compared to the control and monotherapy groups,combined GMP and siSTAT3 nanoparticles effectively induced tumor cell death,downregulated a wide range of pro-tumor signaling pathways and immunosuppressive mediators,eliminated MDSCs,enhanced T cell effector functions in tumors and lymphoid compartments,and led to superior therapeutic efficacy in a syngeneic mouse melanoma model.Additionally,these nanoparticles can serve as adjuvant treatment to improve the therapeutic response of anti-PD-1-based immune checkpoint blockade therapy.Thus,the combination of gemcitabine chemotherapy and STAT3 inhibition through nanotechnology could effectively kill tumor cells,alleviate the immunosuppressive TME,and enhance endogenous antitumor immunity. | Huan Yan Zhanyan Liu Guibin Lin Fei Gu Yan Liu Yuxiao Xu Xueli Kuang Yuan Zhang | 2022 | Nano Research2022，15，10： | 0 |
| 9 | Application of an amphipathic molecule at the NiO_(x)/perovskite interface for improving the efficiency and long-term stability of the inverted perovskite solar cells显示文摘The presence of defects and detrimental reactions at NiO_(x)/perovskite interface extremely limit the efficiency performance and long-term stability of the perovskite solar cells(PSCs) based on NiO_(x).Herein,an amphipathic molecule Triton X100(Triton) is modified on the NiO_(x)surface.The hydrophilic chain of Triton as a Lewis base additive can coordinate with the Ni3+on the NiO_(x)surface which can passivate the interfacial defects and hinder the detrimental reactions at the NiO_(x)/perovskite interface.Additionally,the hydrophobic chain of Triton protrudes from the NiO_(x)surface to prevent moisture from penetrating into the NiO_(x)/perovskite interface.Consequently,the NiO_(x)/Triton-based devices(MAPbI3as absorbing layer) show superior moisture and thermal stability,retaining 88.4% and 64.3% of the initial power conversion efficiency after storage in air(40%-50% relative humidity(RH)) at 25 ℃ for 1070 h and in N2at 85℃ for 800 h,respectively.Moreover,the efficiency increases from 17.59% to 19.89% because of the passivation defect and enhanced hole-extraction capability.Besides,the NiO_(x)/Triton-based PSCs with Cs_(0.05)(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))3perovskite as the light-absorbing layer also exhibits better moisture and thermal stability compared to the control devices,indicating the viability of our strategies.Of particular note,a champion PCE of 22.35% and 20.46% was achieved for small-area(0.1 cm^(2)) and large-area(1.2 cm^(2)) NiO_(x)/Triton-based devices,respectively. | Guibin Shen Hongye Dong Fan Yang Xin Ren Ng Xin Li Fen Lin Cheng Mu | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 10 | Induced temperature-dependent DNA degradation by C_(60) without photoactivation显示文摘This study shows that C_(60) can degrade pBR322 plasmid DNA at room temperature without photoactivation. The degradation was enhanced by increasing incubation temperature, reaction time or C_(60) concentration. We also found that superoxide radical anions (O 2 · ) were formed in the C_(60) solution. Superoxide dismutase significantly inhibited DNA cleavage and O 2 · generation induced by C_(60) . These results suggest that DNA cleavage was caused by the formation of reactive oxygen species induced by C_(60) at room temperature. Furthermore, we demonstrate that the DNA degradation was significantly inhibited by acid amide chemicals such as formamide, and by increased ionic strength of the reaction solution. These results indicate that the DNA conformation stability and the surface properties of C_(60) are important factors regulating DNA degradation. We propose that C_(60) can bind DNA, decrease DNA conformation stability, and induce the formation of reactive oxygen species and DNA cleavage at room temperature. Our results provide a possible explanation for the genotoxicity of C_(60) , which should be considered in future use of this particular nano-material. | WANG Chang LIN Yan WANG Ying LIANG Yong MENG LingZhi ZHANG Jie ZHOU QunFang JIANG GuiBin | 2011 | Chinese Science Bulletin2011，56，28： | 0 |
| 11 | High-Pressure Behavior of Ferromagnesite(Mg_(0.81)Fe_(0.19))CO_(3)by Synchrotron X-Ray Diffraction and Raman Spectroscopy up to 53 GPa显示文摘Ferromagnesite(Mg,Fe)CO_(3)with 20 mol%iron is a potential host mineral for carbon transport and storage in the Earth mantle.The high-pressure behavior of synthetic ferromagnesite(Mg_(0.81)Fe_(0.19))CO_(3)up to 53 GPa was investigated by synchrotron X-ray diffraction(XRD)and Raman spectroscopy.The iron bearing carbonate underwent spin transition at around 44–46 GPa accompanied by a volume collapse of 1.8%,which also demonstrated a variation in the dνi/dP slope of the Raman modes.The pressure-volume data was fitted by a third-order Birch-Murnaghan equation of state(BM-EoS)for the high spin phase.The best-fit K_(0)=108(1)GPa and K_(0)'=4.2(1).Combining the dνi/dP and the K_(0),the mode Grüneisen parameters of each vibrational mode(T,L,ν4 andν1)were calculated.The effects of iron concentration on the Mg_(1−x)Fe_(x)CO_(3)system related to high-pressure compressibility and vibrational properties are discussed.These results expand the knowledge of the physical properties of carbonates and provide insights to the potential deep carbon host. | Lin Liang Guibin Zhang Shengxuan Huang Jingjing Niu Dongzhou Zhang Jingui Xu Wen Liang Shan Qin | 2024 | Journal of Earth Science2024，35，2： | 0 |
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