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| 1 | Exosomes as mediators of neuron-glia communication in neuroinflammation显示文摘In recent years,a type of extracellular vesicles named exosomes has emerged that play an important role in intercellular communication under physiological and pathological conditions.These nanovesicles (30–150 nm) contain proteins,RNAs and lipids,and their internalization by bystander cells could alter their normal functions.This review focuses on recent knowledge about exosomes as messengers of neuron-glia communication and their participation in the physiological and pathological functions in the central nervous system.Special emphasis is placed on the role of exosomes under toxic or pathological stimuli within the brain,in which the glial exosomes containing inflammatory molecules are able to communicate with neurons and contribute to the pathogenesis of neuroinflammation and neurodegenerative disorders.Given the small size and characteristics of exosomes,they can cross the blood-brain barrier and be used as biomarkers and diagnosis for brain disorders and neuropathologies.Finally,although the application potential of exosome is still limited,current studies indicate that exosomes represent a promising strategy to gain pathogenic information to identify therapeutically targets and biomarkers for neurological disorders and neuroinflammation. | María Pascual Francesc Ibánez Consuelo Guerri | 2020 | Neural Regeneration Research2020，15，5： | 14 |
| 2 | Next-generation sequencing:toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure显示文摘A large proportion of patients with idiopathic spermatogenic failure(SPGF;oligozoospermia or nonobstructive azoospermia[NOA])do not receive a diagnosis despite an extensive diagnostic workup.Recent evidence has shown that the etiology remains undefined in up to 75%of these patients.A number of genes involved in germ-cell proliferation,spermatocyte meiotic divisions,and spermatid development have been called into play in the pathogenesis of idiopathic oligozoospermia or NOA.However,this evidence mainly comes from case reports.Therefore,this study was undertaken to identify the molecular causes of SPGF.To accomplish this,15 genes(USP9Y,NR5A1,KLHL10,ZMYND15,PLK4,TEX15,TEX11,MEIOB,SOHLH1,HSF2,SYCP3,TAF4B,NANOS1,SYCE1,and RHOXF2)involved in idiopathic SPGF were simultaneously analyzed in a cohort of 25 patients with idiopathic oligozoospermia or NOA,accurately selected after a thorough diagnostic workup.After next-generation sequencing(NGS)analysis,we identified the presence of rare variants in the NR5A1 and TEX11 genes with a pathogenic role in 3/25(12.0%)patients.Seventeen other different variants were identified,and among them,13 have never been reported before.Eleven out of 17 variants were likely pathogenic and deserve functional or segregation studies.The genes most frequently mutated were MEIOB,followed by USP9Y,KLHL10,NR5A1,and SOHLH1.No alterations were found in the SYCP3,TAF4B,NANOS1,SYCE1,or RH0XF2 genes.In conclusion,NGS technology,by screening a specific custom-made panel of genes,could help increase the diagnostic rate in patients with idiopathic oligozoospermia or NOA. | Rossella Cannarella Rosita A Condorelli Stefano Paolacci Federica Barbagallo Giulia Guerri Matteo Bertelli Sandro La Vignera Aldo E Calogero | 2021 | Asian Journal of Andrology2021，23，1： | 2 |
| 3 | Simulations of the Fluid Flow around a rotating Vertical Axis Wind Turbine显示文摘 | Guerri 0 Sakout A Bouhadef K | | 0，，3： | 1 |
| 4 | 显示文摘 | BELLA S D FRAGALA I GUERRI A | 2004 | Inorg Chim Acta2004，357，4： | 1 |
| 5 | Fluid structure interaction of wind turbine airfoils 显示文摘 | GUERRI O HAMDOUNI A SAKOUT A | 2008 | Wind Engineering2008，32，6： | 1 |
| 6 | Numerical simulation of the flow around oscillating wind turbine airfoils: part 2 free vibrating airfoil 显示文摘 | GUERRI O HAMDOUNI A SAKOUT A | 2008 | Multi- Science Publishing2008，2，4： | 1 |
| 7 | Efficient production of transgenic citrus plants expressing the coat protein gene of Citrus tristeza virus显示文摘 | Dominguez A Guerri J Cambra M | 2000 | Plant Cell Reports2000，，19： | 1 |
| 8 | The campylobacter d54 flagellin promoter is subject to environmental regulation显示文摘 | Alm R A Guerry P Trast T J | 1993 | J Bacteriol1993，175，： | 1 |
| 9 | Redox-stimuli responsive micelles from DOX-encapsulating polycaprolactone-g-chitosan oligosaccha-ride显示文摘 | Guerry A Cottaz S Fleury E | 2014 | Carbohydr Polym2014，112，2： | 1 |
| 10 | Seward LCN The scope and treatment of threats in endangered species recovery plans 显示文摘 | Lawler J J Campbell S P Guerry A D | 2002 | Ecological Applications2002，12，： | 1 |
| 11 | Differential diagnosis of bronchiolitis obliterans with organizing pneumonia and usual interstitial pneumonia:clinical,functional,and radiologic findings显示文摘 | M(U)LLER N L GUERRY FORCE M L STAPLES C A | 1987 | Radiology1987，162，1： | 1 |
| 12 | Differentiation of Citrus tristeaza closterovirus(CTV)idolates by single-strain conformation polymorphism analysis of the coat protein gene显示文摘 | RUBIO B L AYLLON M A GUERRI J | | 0，，： | 1 |
| 13 | Differentiation of citrus tristeza closterovirus isolates by single-strand conformation polymorphism analysis of the coat protein gene显示文摘 | Rubio L Ayllon M A Guerri J | 1996 | Annals of Applied Biology1996，129，： | 1 |
| 14 | Numerical simulation of the fluid flow around a roof mounted wind turbine显示文摘 | Guerri O Sakout A Hamdouni A | | 0，，05： | 1 |
| 15 | Efficient production of transgenic citrus plants expressing the coat pro-tein of citrus tristeza virus显示文摘 | DOMINGUEZ A GUERRI J CAMBRA M NAVARRO L MORENO P PENA L | 2000 | Plant Cell Rep2000，19，04： | 1 |
| 16 | Efficient production of transgenic citrus plants expressing the coat protein gene of citrus tristeza virus显示文摘 | A. Domínguez J. Guerri M. Cambra L. Navarro P. Moreno L. Pe?a | 2000 | Plant Cell Reports2000，，4： | 1 |
| 17 | Efficient production of transgenie citrus plants expressing the coat protein gene of citrus tristeza virus显示文摘 | Dominguez A Guerri J Cambra M | 2000 | Plant Cell Rep2000，19，： | 1 |
| 18 | The campylobacter d54 flagellin promoter is subject to environmental regulation 显示文摘 | Alm R A Guerry P Trast T J | 1993 | J Bacteriol1993，175，： | 1 |
| 19 | A Mobile Device Application Applied to Low Back Disorders 显示文摘 | Guerri J C Anton A B Pajares A | 2009 | Multime- dia Tools and Applications2009，42，3： | 1 |
| 20 | 查看详情显示文摘 | Soo E C Aubry A J Logan S M Guerry P Kelly J F Young N M Thibault P | | 0，，03： | 1 |
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