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| 1 | Exosomes as mediators of neuron-glia communication in neuroinflammation显示文摘In recent years,a type of extracellular vesicles named exosomes has emerged that play an important role in intercellular communication under physiological and pathological conditions.These nanovesicles (30–150 nm) contain proteins,RNAs and lipids,and their internalization by bystander cells could alter their normal functions.This review focuses on recent knowledge about exosomes as messengers of neuron-glia communication and their participation in the physiological and pathological functions in the central nervous system.Special emphasis is placed on the role of exosomes under toxic or pathological stimuli within the brain,in which the glial exosomes containing inflammatory molecules are able to communicate with neurons and contribute to the pathogenesis of neuroinflammation and neurodegenerative disorders.Given the small size and characteristics of exosomes,they can cross the blood-brain barrier and be used as biomarkers and diagnosis for brain disorders and neuropathologies.Finally,although the application potential of exosome is still limited,current studies indicate that exosomes represent a promising strategy to gain pathogenic information to identify therapeutically targets and biomarkers for neurological disorders and neuroinflammation. | María Pascual Francesc Ibánez Consuelo Guerri | 2020 | Neural Regeneration Research2020，15，5： | 14 |
| 2 | Next-generation sequencing:toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure显示文摘A large proportion of patients with idiopathic spermatogenic failure(SPGF;oligozoospermia or nonobstructive azoospermia[NOA])do not receive a diagnosis despite an extensive diagnostic workup.Recent evidence has shown that the etiology remains undefined in up to 75%of these patients.A number of genes involved in germ-cell proliferation,spermatocyte meiotic divisions,and spermatid development have been called into play in the pathogenesis of idiopathic oligozoospermia or NOA.However,this evidence mainly comes from case reports.Therefore,this study was undertaken to identify the molecular causes of SPGF.To accomplish this,15 genes(USP9Y,NR5A1,KLHL10,ZMYND15,PLK4,TEX15,TEX11,MEIOB,SOHLH1,HSF2,SYCP3,TAF4B,NANOS1,SYCE1,and RHOXF2)involved in idiopathic SPGF were simultaneously analyzed in a cohort of 25 patients with idiopathic oligozoospermia or NOA,accurately selected after a thorough diagnostic workup.After next-generation sequencing(NGS)analysis,we identified the presence of rare variants in the NR5A1 and TEX11 genes with a pathogenic role in 3/25(12.0%)patients.Seventeen other different variants were identified,and among them,13 have never been reported before.Eleven out of 17 variants were likely pathogenic and deserve functional or segregation studies.The genes most frequently mutated were MEIOB,followed by USP9Y,KLHL10,NR5A1,and SOHLH1.No alterations were found in the SYCP3,TAF4B,NANOS1,SYCE1,or RH0XF2 genes.In conclusion,NGS technology,by screening a specific custom-made panel of genes,could help increase the diagnostic rate in patients with idiopathic oligozoospermia or NOA. | Rossella Cannarella Rosita A Condorelli Stefano Paolacci Federica Barbagallo Giulia Guerri Matteo Bertelli Sandro La Vignera Aldo E Calogero | 2021 | Asian Journal of Andrology2021，23，1： | 2 |
| 3 | A real-time RT-PCR assay for detection and absolute quantitation of Citrus tristeza virus in different plant tissues显示文摘 | Susana Ruiz-Ruiz Pedro Moreno José Guerri Silvia Ambrós | 2007 | Journal of Virological Methods2007，，2： | 2 |
| 4 | Deteetion and identification of species of the genus Fabavirus by RT- PCR with a single pair of primers显示文摘 | Ferrer R M Luis Arteaga M Guerri J | 2007 | Journal Of VirologicalMethods2007，144，： | 1 |
| 5 | An observational cohort study of Chlamydia trachomatis treatment in pregnancy显示文摘 | Rahangdate L Guerry S Bauer HM | 2006 | Sex Transm Dis2006，33，2： | 1 |
| 6 | Simulations of the Fluid Flow around a rotating Vertical Axis Wind Turbine显示文摘 | Guerri 0 Sakout A Bouhadef K | | 0，，3： | 1 |
| 7 | Critical role of TLR4 response in the activation of microgiia induced by etha- nol显示文摘 | Fernandez-Lizarbe S Pascual M Guerri C | 2009 | J Immunol2009，183，： | 1 |
| 8 | 显示文摘 | BELLA S D FRAGALA I GUERRI A | 2004 | Inorg Chim Acta2004，357，4： | 1 |
| 9 | Discrimination between mild virus and severe Citrus tristeza transcriptionpolymerase isolates with a rapid and highly specific real-time reverse chain reaction method using Taqman LNA probes显示文摘 | RUIZ-RUIZ S MORENO P GUERRI J AMBROS S | 2009 | Phytopathology2009，99，3： | 1 |
| 10 | CheY - mediated modulation of Campylobacter jejuni virulence 显示文摘 | Yao R Burr DH Guerry P | 1997 | Mol Microbiol1997，23，5： | 1 |
| 11 | Bifurcation analysis for a nonlinear system of integro-differendalequadons modelling tumor-immune cells competition显示文摘 | Bellomo N Firmani B Guerri L | 1999 | Applied Mathematics Letters1999，12，2： | 1 |
| 12 | Fluid structure interaction of wind turbine airfoils 显示文摘 | GUERRI O HAMDOUNI A SAKOUT A | 2008 | Wind Engineering2008，32，6： | 1 |
| 13 | Numerical simulation of the flow around oscillating wind turbine airfoils: part 2 free vibrating airfoil 显示文摘 | GUERRI O HAMDOUNI A SAKOUT A | 2008 | Multi- Science Publishing2008，2，4： | 1 |
| 14 | Molecular and behavioral as pects of the actions of alcohol on the adult and developing brain显示文摘 | Alfonso-Loeches S Guerri C | 2011 | Crit Rev Clin Lab Sci2011，48，： | 1 |
| 15 | Recommendations for the use of rituximab in antineutrophil cytoplasm antibody-associated vasculitis显示文摘 | Guerry M J Brogan P Bruce IN | 2012 | Rheumatology (Oxford)2012，51，4： | 1 |
| 16 | Pathogenesis of Campylobacter显示文摘 | Poly F Guerry P | 2008 | Curr Opin Gastroenterol2008，24，1： | 1 |
| 17 | RhoE stimulates neurite-like outgrowth in PC12 cells through inhibition of the RhoA/ROCK-I signalling显示文摘 | Talens-Visconti R Peris B Guerri C Guasch R M | 2010 | J Neurochem2010，112，4： | 1 |
| 18 | Alcohol exposure alters the expression pattern of neural cell adhesion molecules during brain development 显示文摘 | Minana R Climent E Guerri C | 2000 | Neurochem2000，75，3： | 1 |
| 19 | Efficient production of transgenic citrus plants expressing the coat protein gene of Citrus tristeza virus显示文摘 | Dominguez A Guerri J Cambra M | 2000 | Plant Cell Reports2000，，19： | 1 |
| 20 | The campylobacter d54 flagellin promoter is subject to environmental regulation显示文摘 | Alm R A Guerry P Trast T J | 1993 | J Bacteriol1993，175，： | 1 |
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