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| 1 | Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis显示文摘天门冬素(Asn/N ) 连接了 glycans 为蛋白质合拢, trafficking,和 endoplasmic 是重要的在优核质的联系蜂窝胃的降级。glycoproteins 的成熟包含在 Golgi 由另外的糖分子的 mannosidases 和三分支的 N-glycans 的增加整修 mannosyl 残余。然而,调停 Golgi 的甘露糖整修的生物重要性充分没被理解。这里,我们显示出二机能上地冗余的 mannosidases, MNS1 和 MNS2 的那废除,为在 A 和工厂 N-glycans 的 C 分支上整修的 -1,2-mannose 负责在 Arabidopsis 在盐压力条件下面导致严重的根生长抑制。相反,有在 oligosaccharide 先锋的生合成的缺点的异种当甘露糖整修不在时显示了提高的盐忍耐。然而,在 EBS3 的变化,为分叉的 N-glycan 先锋的形成被要求,压制了 mns1 mns2 的盐敏感的显型两倍异种。有趣地,我们观察了那 ? 纤维素生合成在高咸度下面在 mns1 mns2 根被损害。一致地, ? 许多膜抛锚了 endo -- 在纤维素生合成起一个关键作用的 1,4-endoglucanase (RSW2/KOR ) 和它的变异的变体 rsw2-1 ? 被调制由 ? 在盐应力下面整修的 -1,2-mannose。RSW2 的 Overexpression 能部分救 mns1 mns2 的盐敏感的显型。一起拿,这些结果建议 N-glycans 整修的那 MNS1/2-mediated 甘露糖在 modulating glycoprotein 丰富是关键的在植物承受盐应力。 | Chuanfa Liu Guanting Niu Huchen Zhang Yafei Sun Shubin Sun Fugen Yu Shan Lu Yonghua Yang Jianming Li Zhi Hong | 2018 | Molecular Plant2018，11，5： | 3 |
| 2 | A H9N2 Human Case and Surveillance of Avian Influenza Viruses in Live Poultry Markets-Huizhou City,Guangdong Province,China,2021显示文摘Summary What is already known about this topic?An increasing number of human infected avian influenza A(H9N2)cases have been reported.In 2021,11 human infections with influenza A virus subtype H9N2(A/H9N2)have been reported in China.What is added by this report?A new case of H9N2 that occurred in April 2021 in Huizhou City,Guangdong Province,China,was reported in this study.Epidemiological and laboratory information of the case and routine influenza surveillance data of avian influenza A were presented in this report.What are the implications for public health practice?The emergence of a human infected with Avian Influenza Virus H9N2 demonstrates that there is an urgent need to strengthen the surveillance of influenza-like illness and live poultry market. | Guanting Zhang Liqin Xu Jian Zhang Qiaoyun Fang Jianjun Zeng Yan Liu Changwen Ke | 2022 | China CDC weekly2022，4，1： | 2 |
| 3 | Application of fusion PCR to the amplification of full-length ORF sequences of different splicing variants of NuMA 1 from HeLa cells显示文摘 | Jin WU Guanting Lu Jianwei Wu Hua Yang Zhicao Yu Shijie Mu Hongmei Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 0 |
| 4 | A Dugdale-Barenblatt model for elliptical orifice problem with asymmetric cracks in one-dimensional orthorhombic quasicrystals显示文摘By means of Muskhelishvili’s method and the technique of generalized conformal mapping,the physical plane problems are transformed into regular mathematical problems in quasicrystals(QCs).The analytical solution to an elliptical orifice problem with asymmetric cracks in one-dimensional(1D)orthorhombic QCs is obtained.By using the Dugdale-Barenblatt model,the plastic simulation at the crack tip of the elliptical orifice with asymmetric cracks in 1D orthorhombic QCs is performed.Finally,the size of the atomic cohesive force zone is determined precisely,and the size of the atomic cohesive force zone around the crack tip of an elliptical orifice with a single crack or two symmetric cracks is obtained. | Jing ZHANG Guanting LIU | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，9： | 0 |
| 5 | Fine-tuning the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies via branched aliphatic functionalization显示文摘Small-molecule prodrug nanoassemblies have emerged as efficient antitumor drug delivery systems.However,in the case of camptothecins-based prodrug nanoassemblies,linear aliphatic side chain modification often results in rod-shaped or irregularly shaped nanoassemblies,which are highly unfavorable for sterilization through filtration,and may cause capillary blockage upon intravenous injection.The rational design of camptothecins-based prodrug nanoassemblies remains a challenge.Herein,we propose that branched aliphatic alcohol(BAA)functionalization could fine-tune the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies.Correspondingly,four SN38-BAA prodrugs were synthesized by conjugating 7-ethyl-10-hydroxycamptothecin(SN38)with BAAs of varying lengths via a tumor redox-responsive disulfide bond,which self-assemble into uniform spherical nanoparticles.The length of BAA was found to significant impact the multiple drug delivery process,including colloidal stability,drug release profiles and pharmacokinetics.Overall,SN38-C21 NPs(SN38-11-heneicosanol nanoparticles),featuring the longest BAA,showcased multiple therapeutic advantages,ultimately culminating the optimal antitumor efficacy and tolerance.The findings underscore the potential of BAA functionalization in strengthening the therapeutic outcomes of prodrug nanoassemblies,and provide valuable insights for developing translational camptothecins-based nanomedicines. | Guanting Li Fengli Xia Hongying Xiao Shunzhe Zheng Shuwen Fu Han Qiao Qianhui Jin Xuanbo Zhang Dun Zhou Chutong Tian Jin Sun Zhonggui He Bingjun Sun | 2024 | Nano Research2024，17，4： | 0 |
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