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| 1 | Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis显示文摘天门冬素(Asn/N ) 连接了 glycans 为蛋白质合拢, trafficking,和 endoplasmic 是重要的在优核质的联系蜂窝胃的降级。glycoproteins 的成熟包含在 Golgi 由另外的糖分子的 mannosidases 和三分支的 N-glycans 的增加整修 mannosyl 残余。然而,调停 Golgi 的甘露糖整修的生物重要性充分没被理解。这里,我们显示出二机能上地冗余的 mannosidases, MNS1 和 MNS2 的那废除,为在 A 和工厂 N-glycans 的 C 分支上整修的 -1,2-mannose 负责在 Arabidopsis 在盐压力条件下面导致严重的根生长抑制。相反,有在 oligosaccharide 先锋的生合成的缺点的异种当甘露糖整修不在时显示了提高的盐忍耐。然而,在 EBS3 的变化,为分叉的 N-glycan 先锋的形成被要求,压制了 mns1 mns2 的盐敏感的显型两倍异种。有趣地,我们观察了那 ? 纤维素生合成在高咸度下面在 mns1 mns2 根被损害。一致地, ? 许多膜抛锚了 endo -- 在纤维素生合成起一个关键作用的 1,4-endoglucanase (RSW2/KOR ) 和它的变异的变体 rsw2-1 ? 被调制由 ? 在盐应力下面整修的 -1,2-mannose。RSW2 的 Overexpression 能部分救 mns1 mns2 的盐敏感的显型。一起拿,这些结果建议 N-glycans 整修的那 MNS1/2-mediated 甘露糖在 modulating glycoprotein 丰富是关键的在植物承受盐应力。 | Chuanfa Liu Guanting Niu Huchen Zhang Yafei Sun Shubin Sun Fugen Yu Shan Lu Yonghua Yang Jianming Li Zhi Hong | 2018 | Molecular Plant2018，11，5： | 3 |
| 2 | Universal triple I fuzzy reasoning algorithm of function model based on quotient space显示文摘Aiming at the deficiencies of analysis capacity from different levels and fuzzy treating method in product function modeling of conceptual design,the theory of quotient space and universal triple I fuzzy reasoning method are introduced,and then the function modeling algorithm based on the universal triple I fuzzy reasoning method is proposed.Firstly,the product function granular model based on the quotient space theory is built,with its function granular representation and computing rules defined at the same time.Secondly,in order to quickly achieve function granular model from function requirement,the function modeling method based on universal triple I fuzzy reasoning is put forward.Within the fuzzy reasoning of universal triple I method,the small-distance-activating method is proposed as the kernel of fuzzy reasoning;how to change function requirements to fuzzy ones,fuzzy computing methods,and strategy of fuzzy reasoning are respectively investigated as well;the function modeling algorithm based on the universal triple I fuzzy reasoning method is achieved.Lastly,the validity of the function granular model and function modeling algorithm is validated.Through our method,the reasonable function granular model can be quickly achieved from function requirements,and the fuzzy character of conceptual design can be well handled,which greatly improves conceptual design. | Lu Qiang Shen Guanting and Liu Xiaoping | 2012 | Computer Aided Drafting,Design and Manufacturing2012，22，1： | 1 |
| 3 | A Long Type of TBCK Is a Novel Cytoplasmic and Mitotic Apparatus-Associated Protein Likely Suppressing Cell Proliferation显示文摘Autoantibodies from patients with various connective tissue diseases have been shown to be specific probes that can detect cellular structures,including centrosome,centromere/kinetochore,spliceosome,Golgi complex and the rough endoplasmic reticulum(Louvard et al.,1982;Rattner et al.,1998;Monneaux and Muller,2001;Hamaguchi,2010).Previously,we identified three cell cycle-dependent proteins,ICF45,CDCA4,and TCC52,by cDNA library screening using auto- | Jin Wu Qianyi Li Yan Li Jing Lin Dong Yang Guixin Zhu Limin Wang Dacheng He Guanting Lu Changqing Zeng | 2014 | Journal of Genetics and Genomics2014，41，2： | 0 |
| 4 | Application of fusion PCR to the amplification of full-length ORF sequences of different splicing variants of NuMA 1 from HeLa cells显示文摘 | Jin WU Guanting Lu Jianwei Wu Hua Yang Zhicao Yu Shijie Mu Hongmei Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 0 |
| 5 | GAAD: A Gene and Autoimmiune Disease Association Database显示文摘Autoimmune diseases(ADs) arise from an abnormal immune response of the body against substances and tissues normally present in the body. More than a hundred of ADs have been described in the literature so far. Although their etiology remains largely unclear, various types of ADs tend to share more associated genes with other types of ADs than with non-AD types. Here we present GAAD, a gene and AD association database. In GAAD, we collected 44,762 associations between 49 ADs and 4249 genes from public databases and MEDLINE documents. We manually verified the associations to ensure the quality and credibility. We reconstructed and recapitulated the relationships among ADs using their shared genes, which further validated the quality of our data. We also provided a list of significantly co-occurring gene pairs among ADs;with embedded tools, users can query gene co-occurrences and construct customized cooccurrence network with genes of interest. To make GAAD more straightforward to experimental biologists and medical scientists, we extracted additional information describing the associations through text mining, including the putative diagnostic value of the associations, type and position of gene polymorphisms, expression changes of implicated genes, as well as the phenotypical consequences, and grouped the associations accordingly. GAAD is freely available at http://gffzze0e9e6a21d9d4985h00b5p9vckpu065fo.ffgz.tsg.suse.edu.cn. | Guanting Lu Xiaowen Hao Wei-Hua Chen Shijie Mu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 0 |
| 6 | Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes显示文摘The unique characteristics of the tumor microenvironment(TME)could be exploited to develop antitumor nanomedicine strategies.However,in many cases,the actual therapeutic effect is far from reaching our expectations due to the notable tumor heterogeneity.Given the amplified characteristics of TME regulated by vascular disrupting agents(VDAs),nanomedicines may achieve unexpected improved efficacy.Herein,we fabricate platelet membrane-fusogenic liposomes(PML/DP&PPa),namely“platesomes”,which actively load the hypoxia-activated pro-prodrug DMG-PR104A(DP)and physically encapsulate the photosensitizer pyropheophorbide a(PPa).Considering the different stages of tumor vascular collapse and shutdown induced by a VDA combretastatin-A4 phosphate(CA4P),PML/DP&PPa is injected 3 h after intraperitoneal administration of CA4P.First,CA4P-mediated tumor hemorrhage amplifies the enhanced permeation and retention(EPR)effect,and the platesome-biological targeting further promotes the tumor accumulation of PML/DP&PPa.Besides,CA4P-induced vascular occlusion inhibits oxygen supply,followed by photodynamic therapy-caused acute tumor hypoxia.This prolonged extreme hypoxia contributes to the complete activation of DP and then high inhibitory effect on tumor growth and metastasis.Thus,such a combining strategy of artificially-regulated TME and bio-inspired platesomes pronouncedly improves tumor drug delivery and boosts tumor hypoxia-selective activation,and provides a preferable solution to high-efficiency cancer therapy. | Wenhui Tao Dongyang Zhao Guanting Li Lingxiao Li Songhao Li Hao Ye Chutong Tian Yutong Lu Shuying Li Yinghua Sun Zhonggui He Jin Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 0 |
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