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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | Sterol changes during germination of Nicotiana tabacum seeds 显示文摘 | BUSH P B GRUNWALD C | 1972 | Plant Physiology1972，50，1： | 1 |
| 4 | Duvatrienediol, alkanes, and fatty acids in cuticular wax of tobacco leaf of various physiological maturity显示文摘 | Chang S Y Grunwald C | 1976 | Phytochemistry1976，，15： | 1 |
| 5 | Targeting vascular endothelial growth factor (VEGF)-recep- tor-signaling in renal cell carcinoma 显示文摘 | Reuter C W Morgan M A Grunwald V | 2007 | World J Urol2007，25，1： | 1 |
| 6 | Determination of phenolic hydroxyl group content of milled wood lignins ( MWL' s) from different botanical origins usiog selective aminolysis, FTIR,1HNMR and UV spectroscopy显示文摘 | Faix O Grunwald C Beinhoff O | 1992 | Holzforsehung1992，46，： | 1 |
| 7 | Plant sterols显示文摘 | Grunwald C | 1975 | Annual Review of Plant Biology1975，26，： | 1 |
| 8 | Redifferentiation therapyinduced radioiodine uptake in thyroid cancer显示文摘 | Grunwald F Menzel C Bender H | 1998 | J Nucl Med1998，39，11： | 1 |
| 9 | Ductoscopy-based descriptors of intraductal lesions and their histopathologic correlates显示文摘 | Rose C Bojahr B Grunwald S | 2010 | Onkologie2010，33，6： | 1 |
| 10 | Duvatrienediols in cuticular wax of Burley tobacco leaves 显示文摘 | Chang S Y Grunwald C | 1976 | J Lipid Res1976，17，1： | 1 |
| 11 | Duvatrienediol,alkanes,and fatty acids in cuticular wax of tobacco leaf of various physio- logical maturity 显示文摘 | CHANG S Y GRUNWALD C | 1976 | Phytochemistry1976，15，： | 1 |
| 12 | Population ge- netics of shortnose sturgeon Acipenser brevirostrum based on mitochondrial DNA control region sequences显示文摘 | Grunwald C Stabile J Waldman J R | 2002 | Mol Ecol2002，11，10： | 1 |
| 13 | GIS:based hydrologic modeling in the Sandusky watershed using SWAT显示文摘 | QI C GRUNWALD S | 2005 | Trans ASAE2005，48，1： | 1 |
| 14 | Efficacy of sunitinib re- exposure after failure of an roTOR inhibitor in patients with meta- static RCC显示文摘 | Grunwald V Weikert S Seidel C | 2011 | Onkologie2011，34，6： | 1 |
| 15 | Dynamics of bacterial population in relation to carbon availability in a residue amended soil显示文摘 | HU S J VAN BRUGGEN A H C GRUNWALD N J | 1999 | Applied Soil Ecology1999，13，： | 1 |
| 16 | Comparative study of topological and geometrical parameters in estimating normal boiling points and octanol water partition coefficient显示文摘 | BASAK A C GUTE B D GRUNWALD G D | 1996 | J Chem Inf Comput Sci1996，36，： | 1 |
| 17 | Redifferentiation therapy-induced radioiodine uptake in thyroid cancer 显示文摘 | Grunwald F Menzel C Bender H | 1998 | J Nucl Med1998，39，： | 1 |
| 18 | Nonlinear denoising of transient signals with application to event-related potentials显示文摘 | Effern A Lehnertz K Schreiber T Grunwald T David P Elger C E | 2000 | Physica D2000，140，： | 1 |
| 19 | Induction and clearance of cytochrome P4501AmRNA in Atlan- tic tomcod caged in bleached kraft mill effluent in the Miramichi River 显示文摘 | Courtenay S Grunwald C kreamer G | 1993 | Aquatic Toxicology1993，27，： | 1 |
| 20 | Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity显示文摘 | Grunwald I C Korte M Wolfer D | 2001 | Neuron2001，32，6： | 1 |
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