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| 1 | A peptide encoding a B-cell epitope from the N-terminus of the capsid protein L2 of bovine papillomavirus-4 prevents disease 显示文摘 | CAMPO MS O'NEIL BW GRINDLAY GJ | 1997 | Virology1997，234，2： | 1 |
| 2 | Towards an explanation of crop nitrogen demand based on the optimization of leaf nitrogen per unit leaf area显示文摘 | Grindlay D J C | 1997 | The Journal of Agricultural Science1997，128，： | 1 |
| 3 | L-carnitine supplementation in non-alcoholic fatty liver disease: A systematic review and meta-analysis显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)dominates the landscape of modern hepatology.Affecting 25%of the general population,there is critical unmet need to identify broadly available,safe and cost-effective treatments.Cumulative evidence in animal and human models suggests that intrahepatic and skeletal muscle fatty acid oxidation is impaired in NAFLD,such that lipid accretion is not matched by efficient utilisation.L-carnitine is a crucial mediator of fatty acid metabolism in vivo,promoting mitochondrial lipidβ-oxidation and enhancing tissue metabolic flexibility.These physiological properties have generated research interest in L-carnitine as a potentially effective adjunctive therapy in NAFLD.AIM To systematically review randomised trials reporting effects of dietary L-carnitine supplementation on liver biochemistry,liver fat and insulin sensitivity in NAFLD.METHODS Search strategies,eligibility criteria and analytic methods were specified a priori(PROSPERO reference:CRD42018107063).Ovid MEDLINE,Ovid EMBASE,PubMed,Web of Science and the Cochrane Library were searched from their inception until April 2019.Outcome measures included serum concentrations of alanine and aspartate aminotransferase(ALT and AST),liver fat and insulin sensitivity assessed by the homeostasis model of insulin resistance(HOMA-IR).A random effects meta-analysis was performed for,ALT,AST and HOMA-IR measures separately.Between-study heterogeneity was measured using I2 statistics.RESULTS Five eligible randomised trials were included in the qualitative and quantitative synthesis(n=338).All of the 5 included trials assessed the effect of L-carnitine on serum ALT,identified from Italy,South Korea and Iran.Weighted mean difference(WMD)for ALT between L-carnitine and control groups after intervention was-25.34 IU/L[95%CI:-41.74-(-8.94);P=0.002].WMD for AST between L-carnitine and control groups was-13.68 IU/L(95%CI:-28.26-0.89;P=0.066).In three studies(n=204),HOMA-IR was evaluated.WMD for HOMA-IR between L-carnitine and control groups was-0.74 units[95%CI:-1.02-(-0.46);P<0.001].Two studies using validated outcome measures reported a significant reduction in liver fat in L-carnitine vs control groups post-intervention(P<0.001).CONCLUSION Pooled results indicate that L-carnitine supplementation attenuates ALT,liver fat and insulin resistance in NAFLD cohorts,confirming a beneficial effect of Lcarnitine for a highly prevalent condition with a growing economic burden. | Prarthana Thiagarajan Jane Chalmers Lu Ban Douglas Grindlay Guruprasad P Aithal | 2020 | World Journal of Meta-Analysis2020，8，1： | 1 |
| 4 | Management of acne vul- garis: an evidence-based update显示文摘 | Ingram JR Grindlay DJC Williams HC | 2010 | Clin Experimental Dermatol2010，35，4： | 1 |
| 5 | Regulation of human myoblast differentiation by PEBP4显示文摘 | Garcia R Grindlay J Rath O | | 0，，03： | 1 |
| 6 | Whats new in acne An analysis of systematic reviews published in 2009- 2010 显示文摘 | Smith EV Grindlay D J Williams HC | 2011 | Clin Exp Dermatol2011，36，2： | 1 |
| 7 | Technique for the collection of lymph from the liver, small intestine or thoracic duct of the rat 显示文摘 | Bollman JL Cain JC Grindlay JH | 1948 | J Lab Clin Med1948，33，7： | 1 |
| 8 | Atomic spectrometrymethods for wine analysis: a critical evaluation and discussion ofrecent applications显示文摘 | GRINDLAY G MORA J GRAS L | 2011 | Analytica Chimica Acta2011，691，12： | 1 |
| 9 | Building large area CZT imaging detectors for a wide-field hard X-ray telescope ProtoXIST1显示文摘 | Hong J Allen B Grindlay J | 2009 | Nucl Instrum Methods A2009，605，： | 1 |
| 10 | The Mid- Atlantic Ridge(31-34S) : Temporal and spatial variations o{ accretionary processes 显示文摘 | Fox P J Grindlay N R Macdonald K C | 1991 | Marine Geophysical Researches1991，13，： | 1 |
| 11 | Morphology and tectonics of the Mid-Atlantic Ridge (25-2730' S) from SeaBeam andmagnetic data 显示文摘 | Grindlay N R Fox P J Vogt P R | 1992 | Journal of Geophysical Research1992，13，： | 1 |
| 12 | Toward an explanation of crop nitrogen demand based on the ptimization of leaf nitrogen per unit leaf area显示文摘 | Grindlay D J C | 1997 | Journal of Agricultural Science1997，128，： | 1 |
| 13 | Application of amicrowave-based desolvation system for multi-elemental analysis ofwine by inductively coupled plasma based techniques显示文摘 | GRINDLAY G MORA J MAESTRE S | 2008 | AnalyticaChimica Acta2008，629，12： | 1 |
| 14 | The bronchial arteries显示文摘 | Ellis FH Grindlay JH Edwards JE | | 0，，05： | 1 |
| 15 | Techniques for collection of lymph from li ver,small intestine or thoracic duct of the rat显示文摘 | Bollman J L Caim J C Grindlay J H | 1948 | J Lab Clin Med1948，33，： | 1 |
| 16 | A different pattern of ridge segmentation and mantle Bouguer gravity anomalies along the ultra-slow spreading Southwest Indian Ridge (15 30r E to 25 E) 显示文摘 | Grindlay N R Madsen J Rommevaux-Jestin J | 1998 | Earth Planetary Science Letters1998，161，： | 1 |
| 17 | Building large area CZT imaging detectors for a wide-field hard X-ray telescope-ProtoEXIST1显示文摘 | Hong J Allen B Grindlay J | 2009 | Nucl Instrum Meth Phys Res A2009，605，3： | 1 |
| 18 | What' s new in acne? An a- nalysis of systematic reviews published in 2009 - 2010 显示文摘 | Smith EV Grindlay DJ Williams HC | 2011 | Clin Exp Dermatol2011，36，2： | 1 |
| 19 | Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5 显示文摘 | von Kriegsheim A Pitt A Grindlay GJ | 2006 | Nat Cell Biol2006，8，9： | 1 |
| 20 | Development of gold contacted flip-chip detectors with IMARAD CZT 显示文摘 | NARITE T BLOSER P F GRINDLAY J E | 2000 | Proceedings of SPIE2000，4141，： | 1 |
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