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| 1 | Spatial-temporal patterns in Mediterranean carnivore road casualties:Consequences for mitigation显示文摘 | Grilo C Bissonette JA Reis MS | | 0，，： | 1 |
| 2 | Self-criticism,low self-esteem,depressive symptoms,and over-evaluation of shape and weight in hinge eating disorder patients显示文摘 | DUNKLEY D M GRILO C M | 2007 | Behav Res Ther2007，45，： | 1 |
| 3 | Timing and sequence of the onset of overweight, dieting, and binge eating in overweight patients with binge eating disorder 显示文摘 | REAS D L GRILO C M | 2007 | Int J Eat Disord2007，40，2： | 1 |
| 4 | Do well-connected land- scapes promote road related mortality? 显示文摘 | Grilo C Ascensao F Santos-Reis M | 2011 | European Journal of Wildlife Research2011，57，： | 1 |
| 5 | Perfectionism and depressive symptoms 3 years later: negative social interactions, avoidant coping, and perceived social support as mediators显示文摘 | Dunkley D M Sanislow C A Grilo C M | 2006 | Compr Psychiatry2006，47，2： | 1 |
| 6 | DNA- protein cross-links and sister chromatid exchanges induced by dimethylarsinic acid in human fibroblasts cells 显示文摘 | Mouton S A Grilo C A Dulout F N | 2005 | Mutation Research2005，581，12： | 1 |
| 7 | MtvR is a global regulatory sRNA in Burkholderia cenocepacia显示文摘 | Ramos C G Grilo A M da Costa P J P | 2013 | J Bac- teriol2013，195，： | 1 |
| 8 | Correlates of suicide risk in adolescent inpatients who re port a history of childhood abuse显示文摘 | Grilo Carlos M Sanislow Charles A Fehon Dwain C | 1999 | Comprehensive Psychiatry1999，40，： | 1 |
| 9 | Negative weight-based attitudes in treat-ment-seeking obese monolingual Hispanic patients withand without binge eating disorder显示文摘 | Puhl R M White M A Paris M Anez L M Silva M A Grilo C M | 2011 | Compr Psychiat2011，52，： | 1 |
| 10 | An analytical model for transport layer caching in wireless sensor networks显示文摘 | Tiglao N M C Grilo A M | 2012 | Performance Evaluation2012，69，5： | 1 |
| 11 | Childhood maltreatment in extremely obese male and female bariatric surgery candidates显示文摘 | Masheb R M Brody M | 2005 | Obesity Research2005，13，1： | 1 |
| 12 | Teasing history, onset of obesity, current eating disorder psychopathology, body dissatisfaction, and psychological functioning in binge eating disorder显示文摘 | Grilo C M Masheb R M | 2000 | Obes Res2000，8，6： | 1 |
| 13 | Imaging probes for non-invasive tumoral detection and functional monitoring of cancer multidrug resistance显示文摘Aim:Several cationic radiotracers originally developed as myocardial perfusion agents have shown potential for both early detection of cancer and non-invasive monitoring of multiple drug resistance(MDR)by single photon emission computed tomography.We have introduced two cationic complexes,^(99m)Tc-DMEOP[di-methoxy-tris-pyrazolyl-^(99m)Tc-(CO)_(3)]and ^(99m)Tc-TMEOP[tri-methoxy-tris-pyrazolyl-^(99m)Tc-(CO)_(3)],which showed excellent preclinical results as cardiac imaging probes,namely a persistent heart uptake with rapid blood and liver clearance.This study aimed at the evaluation of their usefulness for tumoral detection and functional assessment of MDR.Methods:The uptake and efflux kinetics of ^(99m)Tc-DMEOP and ^(99m)Tc-TMEOP were evaluated in human prostate,lung,and breast cancer cell lines,including drug-resistant cell lines that are known to overexpress the MDR P-glycoprotein(Pgp).The effects of MDR modulators were also studied.In vivo studies were performed in xenografted tumor models,and the MDR phenotype of the tumors was confirmed by Western blot.Results:The uptake kinetics of both complexes in human cancer cell lines is comparable with the one found for ^(99m)Tc-Sestamibi,increasing over time.The uptake of ^(99m)Tc-TMEOP is greatly reduced in cells overexpressing Pgp and increased in the presence of a Pgp modulator.In nude mice,the tumor uptake of ^(99m)Tc-TMEOP was higher in the MCF-7 xenografts compared with the MCF7 Pgp tumors.Conclusion:The uptake kinetics of both complexes in human cancer cell lines is comparable with the one found for ^(99m)Tc-Sestamibi,increasing over time.The uptake of ^(99m)Tc-TMEOP is greatly reduced in cells overexpressing Pgp,and increased in the presence of a Pgp modulator.In nude mice,the tumor uptake of ^(99m)Tc-TMEOP was higher in the MCF-7 xenografts compared with the MCF7 Pgp tumors. | Filipa Mendes Lurdes Gano Jorge Grilo Susana Cunha Célia Fernandes António Paulo | 2020 | Cancer Drug Resistance2020，3，2： | 0 |
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