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| 1 | Perinatal and early life risk factors for inflammatory bowel disease显示文摘AIM:To investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.METHODS:Record linked abstracts of birth registrations,maternity,day case and inpatient admissions in a defined population of southern England.Investigation of 20 perinatal factors relating to the maternity or the birth:maternal age,Crohn's disease (CD) or ulcerative colitis (UC) in the mother,maternal social class,marital status,smoking in pregnancy,ABO blood group and rhesus status,pre-eclampsia,parity,the infant's presentation at birth,caesarean delivery,forceps delivery,sex,number of babies delivered,gestational age,birthweight,head circumference,breastfeeding and Apgar scores at one and five minutes.RESULTS:Maternity records were present for 180 children who subsequently developed IBD.Univariate analysis showed increased risks of CD among children of mothers with CD (P=0.011,based on two cases of CD in both mother and child) and children of mothers who smoked during pregnancy.Multivariate analysis confirmed increased risks of CD among children of mothers who smoked (odds ratio=2.04,95% CI=1.06-3.92) and for older mothers aged 35+ years (4.81,2.32-9.98).Multivariate analysis showed that there were no significant associations between CD and 17 other perinatal risk factors investigated.It also showed that,for UC,there were no significant associations with the perinatal factors studied.CONCLUSION:This study shows an association between CD in mother and child;and elevated risks of CD in children of older mothers and of mothers who smoked. | Stephen E Roberts Clare J Wotton John G Williams Myfanwy Griffith Michael J Goldacre | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 2 | Microorganisms and heavy metal toxicity 显示文摘 | Gadd G M Griffiths A J | 1978 | Microb Ecol1978，4，： | 1 |
| 3 | Rapid method for coextraction of DNA and RNA from natural environments for analysis of ribosomal DNA- and rRNA-based microbial community composition 显示文摘 | Griffiths R I Whiteley A S O'Donnell A G | 2000 | Appl Environ Microb2000，66，12： | 1 |
| 4 | RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast显示文摘 | Kleer C G Griffith K A Sabel M S | 2005 | Breast Cancer Res Treat2005，93，2： | 1 |
| 5 | Tissue engineering-current challenges and expanding opportunities显示文摘 | Griffith LG Naughton G | 2002 | Science2002，295，5557： | 1 |
| 6 | Tracking fish by airborne radar - fishermen could be the winner显示文摘 | GRIFFITHS F B LYNE V D HARRIS G P et el | 1989 | Australian Fisheries1989，48，： | 1 |
| 7 | Isoniazid prophylaxis for tuberculosis in HIV infection:a meta analysis of randomized controlled trials显示文摘 | Bucher H C Griffith L Guyatt G | 1999 | AIDS1999，13，： | 1 |
| 8 | Conjugation of an anti-B-cell lymphoma monoclonal antibody, LL2, to long- circulating drug-carrier lipid emulsions 显示文摘 | Lundberg BB Griffiths G Hansen HJ | 1999 | J Pharm Pharmacol1999，51，10： | 1 |
| 9 | Making antibodies by phage display technology 显示文摘 | Winter G Griffiths AD Hawkins RE | 1994 | Annu Rev Immunol1994，12，： | 1 |
| 10 | A framework for biological criteria for Florida streams using benthic macroinvertebrates 显示文摘 | BARBOUR M T GERRITSEN J GRIFFITH G E | 1996 | Journal of the North American Benthological Society1996，15，2： | 1 |
| 11 | A framework for biological criteria for Florida streams using benthic macroinvertebrates显示文摘 | Barbour M T Gerritsen J Griffith G E | 1996 | Journal of the North American Benthological Society1996，15，： | 1 |
| 12 | Functional gene polymorphisms in aggressive and chronic periodontitis 显示文摘 | BRETT P M ZYGOGIANNI P GRIFFITHS G S | 2005 | J Dent Res2005，84，12： | 1 |
| 13 | Disturbed memory amnesia related to intensive care显示文摘 | JONES C GRIFFITHS R D HUMPHRIS G | 2000 | Memory2000，8，2： | 1 |
| 14 | Evolution of quasiparticle charge in the fractional quantum hall regime 显示文摘 | Griffiths T G Comforti E Heiblum M | 2000 | Phvs Rev Lett2000，85，18： | 1 |
| 15 | Compar- ison of the quality of protection on elicited by toxoid and peptide liposomal vaccine formulations against riein as as- sessed by markers of inflammation 显示文摘 | GRIFFITHS G D PHILLIPS G J BAILEY S C | 1999 | Vaccine1999，17，： | 1 |
| 16 | Cortical activation during perception of a rotating wide-field acoustic stimulus显示文摘 | GRIFFITHS T D GREEN G G | 1999 | Neuroimage1999，10，： | 1 |
| 17 | E-valuation of bupivacaine - induced muscle regeneration in the treat-ment of ptosis in patients with chronic progressive external ophthal-moplegia and Kearns - Sayre syndrome 显示文摘 | ANDREWS R M GRIFFITHS P G CHINNERY P F | 1999 | Eye ( Lond)1999，13，6： | 1 |
| 18 | Pitfalls of immunogold labeling; analysis by light microscopy,transmission electron microscopy,and photoelectron microscopy显示文摘 | Birrell G B Hedberg K K Griffith P H | 1987 | Journal of Histochemistry and Cytochemistry1987，35，： | 1 |
| 19 | Iterative Closest Geometric Objects Registration 显示文摘 | Li Q Griffiths J G | 2000 | Computers and Mathematics with Applications2000，40，10： | 1 |
| 20 | Effect of pulsed electric filed on the inactivation of micro organisms in grape juices with and without antimicrobials 显示文摘 | Wu Y Mittal G S Griffiths M W | 2005 | Biosystems Engineering2005，90，1： | 1 |
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