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| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | Regulation of adiposity by dietary calcium显示文摘 | ZEMEL M B SHI H GREER B | 2000 | FASEB Journal2000，14，： | 2 |
| 4 | Lactic acid inhibition of the growth of spoilage bacteria and cold tolerant pathogens on pork 显示文摘 | GREER G G DILTS B D | 1995 | Int J Food Microb1995，25，： | 1 |
| 5 | The effect of age on clinical/pathologic features surgical morbidity and outcome in patients with endometrial cancer显示文摘 | Lachance JA Everett EN Greer B | 2006 | Gynecol Oncol2006，101，： | 1 |
| 6 | The aerobic growth of Aeromonas hydrophila and Listeria monocytogenes in broths and on pork显示文摘 | GILL C O GREER G G DILTS B D | 1997 | Int J Food Microbiol1997，35，： | 1 |
| 7 | Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes显示文摘 | GREER R M PORTELLI S L HUNG B S | 2013 | Pediatr Diabetes2013，，： | 1 |
| 8 | Gastric secretory,response to head injury显示文摘 | Greer J Eiseman B | 1970 | Arch Surg1970，101，2： | 1 |
| 9 | Regulation of adiposity by dietary calcium 显示文摘 | Zemel MB Shi H Greer B | 2000 | FASEB J2000，14，9： | 1 |
| 10 | Comparison of two methods for anteriorposterior isocenter localization in pelvic radiotherapy using electronic portal imaging显示文摘 | Greer P B Mortensen T M Jose C C | 1998 | Int J Radiat Oncol Biol Phys1998，41，： | 1 |
| 11 | Techniques for applying subatmospheric pressure dressing to wounds in difficult regions of anatomy显示文摘 | Greer SE Duthie E Cartolano B | 1999 | J Wound Ostomy Continence Nurs1999，26，5： | 1 |
| 12 | Strong responses of growth and photosynthesis of five C3 pasture species to elevated CO2 at low temperatures显示文摘 | Laing W A Greer D H Campbell B D | 2002 | Functional Plant Biology2002，29，9： | 1 |
| 13 | Tissue and cellu- lar tropism, pathology and pathogenesis of Ebola and Mar- burg viruses显示文摘 | Martines R B Ng D L Greer P W | 2015 | J Pathol2015，235，2： | 1 |
| 14 | Uterine papillary serious carcinoma:evaluation of long-term survival surgically staged patients显示文摘 | Grice J EK M Greer B | 1998 | Gynecol Oncol1998，69，1： | 1 |
| 15 | Aerosol sampling: comparison of two rotating impactors for field droplet sizingand volumetric measurements显示文摘 | Bonds J A S Greer M J Fritz B K | 2009 | Journal of the American Mosquito Control Association2009，25，4： | 1 |
| 16 | The Angelman syndrome protein Ube3A regulates synapse development by ubiquitinating arc显示文摘 | Greer P L Hanayama R Bloodgood B L | | 0，，05： | 1 |
| 17 | Regulation of adiposity by dietary calcium 显示文摘 | Zemel MB Shi H Greer B | 2000 | FASEB J2000，14，9： | 1 |
| 18 | Microbial functional potential and community composition in permafrost-affected soils of the NW Canadian Arctic显示文摘 | FRANK-FAHLE B A YERGEAU E GREER C W | 2014 | The Public Library of Science2014，9，84： | 1 |
| 19 | Predicting the growth of Escheri- chia coli on displayed pork显示文摘 | GILL C O GREER G G DILTS B D | 1998 | Food Microbiology1998，15，2： | 1 |
| 20 | Techniques for applying subatmospheric pressure dressing to wounds in difficult regions of anatomy显示文摘 | Greer SE Duthie E Cartolano B | | 0，，05： | 1 |
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