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| 1 | MicroRNA Expression Profiles and MiR-10a Target in Anti-benzo[a] pyrene-7,8-diol-9,10-epoxide-transformed Human 16HBE Cells显示文摘<正>Objective To screen miRNA profiles of malignantly transformed human bronchial epithelial cells,16HBE-T,induced by anti-benzo[a]pyrene-trans-7,8-diol-9,10-epoxide(anti-BPDE),and to analyze putative miR-10a targets in 16HBE-T.Methods A hovel microarray platform was employed to screen miRNA profiles of 16HBE-T cells transformed by anti-BPDE.Microarray data for miR-10a and miR-320 were validated using quantitative real time polymerase chain reaction(QRT-PCR).The expression of a putative target for miR-10a,HOXA1,was analyzed by reverse transcription polymerase chain reaction(RT-PCR) and QRT-PCR.Results In comparison with the vehicle-treated cells(16HBE-N),16HBE-T exhibited difierential expression of 54 miRNAs,in which,45 were over-expressed and 9 were down-regulated.The five most highly expressed miRNAs were miR-494,miR-320,miR-498,miR-129,and miR-106a.The lowest expressed miRNAs were miR-10a,miR-493-5p,and miR-363~*.Three members of miR-17-92 cluster,miR-17-5p,miR-20a,and miR-92,showed significantly higher abundance in 16BHE-T as miR-21,miR-141,miR-27a,miR-27b,miR-16 and miRNAs of the let-7 family.The putative target for miR-10a, HOXA1 mRNAwas up-regulated 3-9-foldin 16HBE-T,as compared with 16HBE-N.Conclusion Thefindings of the study provide information on differentially expressed miRNA in malignant 16HBE-T,and also suggest a potential role of these miRNAs in cell transformation induced by anti-BPDE.HOXA1 is similarly up-regulated,suggesting that miR-10a is associated with the process of HOXA1-mediated | YUE-LAN SHEN YI-Guo JIANG ANNE R. GREENLEE LAN-LAN ZHOU LIN-HUA LIU | 2009 | Biomedical and Environmental Sciences2009，22，1： | 26 |
| 2 | Basic science of water: Challenges and current status towards a molecular picture显示文摘在指向水相关的问题的基本科学和现代技术的快速的开发包括我们的行星和环境的物理性质,生活,经由切开的水的精力生产,和水纯化的起源,为水的分子水平的理解的所有调用。这调用无情的努力推进我们水的基本科学的理解。完成水的古怪性质和行为的一幅分子的图画的当前的挑战此处被讨论,与体积和表面水的结构和动力学的一个特别焦点,弄湿并且切开的水的分子的机制,关于水净化和脱盐的面向申请的研究,并且为在 nanoscale 探查水的互补技术的发展。 | Sheng Meng Lauren F. Greenlee Yuen Ron Shen Enge Wang | 2015 | Nano Research2015，8，10： | 3 |
| 3 | Cancer statistics, 2000显示文摘 | Greenlee RT Murray T Bolden S | 2000 | CA CancerJ Clin2000，50，1： | 3 |
| 4 | Reverse osmosis desalination: Water sources, technology, and today’s challenges显示文摘 | Lauren F. Greenlee Desmond F. Lawler Benny D. Freeman Benoit Marrot Philippe Moulin | 2009 | Water Research2009，，9： | 3 |
| 5 | Long-term results of side-to-side pancreaticojejunostomy显示文摘 | Herbert B. Greenlee M.D. Richard A. Prinz M.D. Gerard V. Aranha M.D | 1990 | World Journal of Surgery1990，，1： | 3 |
| 6 | Cancer statistics, ,2000显示文摘 | Greenlee RT Murray T Bolden S Wingo PA | | 0，，： | 2 |
| 7 | Kinetics and inhibition of lipid exchange catalyzed by plasma cholesteryl ester transfer protein (lipid transfer protein) 显示文摘 | Epps DE Greenlee KA Harris JS | 1995 | Biochemistry1995，34，12： | 2 |
| 8 | Reverse osmosis desalination;Water sources,technology,and today's challenges显示文摘 | GREENLEE L F LAWLER D F FREEMAN B D et aI | 2009 | Water Research2009，43，： | 1 |
| 9 | Cancer statistics显示文摘 | GREENLEE R T MURRAY T BOLDEN S | 2000 | CA Cancer J Clin2000，50，： | 1 |
| 10 | Effect of seiencing of HER2/neu gene in anti-BPDE-transformed cells 显示文摘 | Jiang Y Fu J Greenlee A R Shen YoDuan H Chen X | 2009 | Toxicol In Vitro2009，23，： | 1 |
| 11 | Cancer statistics ,2000 显示文摘 | Greenlee RT Murray Bolden S Wingo PA | 2000 | CA Cancer J Clin2000，50，： | 1 |
| 12 | Cholecystectomy in cirrhotic patients : a formidable operation显示文摘 | Aranha GV Sontag SJ Greenlee HB | 1982 | Am J Surg1982，143，1： | 1 |
| 13 | Cancer statisties, 200l 显示文摘 | Greenlee RT Murray T Bolden S | 2001 | CA Cancer J Clin2001，51，： | 1 |
| 14 | Cancer statistics 显示文摘 | Greenlee RT Murray T Bolden S | 2000 | CA Cancer J Clin2000，50，1： | 1 |
| 15 | Double-blind, prospective, randomized study of warmed, humidified carbon dioxide for patients undergoing laparoscopic cholecystectomy 显示文摘 | Farley DR Greenlee SM Larson DR | 2004 | Arch Surg2004，139，7： | 1 |
| 16 | Retaining Teachers in Challenging School显示文摘 | Greenlee B Brown J J Jr | 2009 | Education2009，130，1： | 1 |
| 17 | Aryl hydrocarbon receptor regulates cell cycle progression in human breast cancer cells via a functional interaction with cyclin-dependent kinase 4 显示文摘 | Barhoover MA Hall JM Greenlee WF | 2010 | Mol Pharmacol2010，77，2： | 1 |
| 18 | Cancer statistics, 2001 显示文摘 | Greenlee RT Hill-Harmon MB Murray T | 2001 | CA Cancer J Clin2001，51，1： | 1 |
| 19 | Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against streptococcus pneumoniae 显示文摘 | Hong J S Greenlee K J Pitchumani R | 2011 | J Immunol2011，186，11： | 1 |
| 20 | Cancer statistics, 2001 显示文摘 | Greenlee RT Hill-Harmon MB Murray T | 2001 | CA Cancer J Clin2001，51，1： | 1 |
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