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| 1 | Approach to early-onset colorectal cancer:Clinicopathological,familial,molecular and immunohistochemical characteristics显示文摘AIM:To characterize clinicopathological and familial features of early-onset colorectal cancer(CRC) and compare features of tumors with and without microsatellite instability(MSI).METHODS:Forty-five patients with CRC aged 45 or younger were included in the study.Clinical information,a three-generation family history,and tumor samples were obtained.MSI status was analyzed and mismatch repair genes were examined in the MSI families.Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies.RESULTS:Early onset CRC is characterized by advanced stage at diagnosis,right colon location,low-grade of differentiation,mucin production,and presence of polyps.Hereditary forms represent at least 21% of cases.Eighty-one percent of patients who died during followup showed a lack of expression of cyclin E,which could be a marker of poor prognosis.β-catenin expression was normal in a high percentage of tumors.CONCLUSION:Early-onset CRC has an important familial component,with a high proportion of tumors showing microsatellite stable.Cyclin E might be a poor prognosis factor. | Jose Perea Edurne Alvaro Yolanda Rodríguez Cristina Gravalos Eva Sánchez-Tomé Barbara Rivera Francisco Colina Pablo Carbonell Rogelio González-Sarmiento Manuel Hidalgo Miguel Urioste | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 2 | A randomized phase II study to compare oxaliplatin plus 5-fluorouracil and leucovorin (FOLFOX4) versus oxaliplatin plus raltitrexed (TOMOX) as first-line chemotherapy for advanced colorectal cancer显示文摘 | Cristina Gravalos Antonieta Salut Carlos García-Girón Rocío García-Carbonero Ana León Isabel Sevilla Joan Maurel Beatriz Esteban Eduardo García-Rico Adolfo Murias Hernán Cortés-Funes | 2012 | Clinical and Translational Oncology2012，，8： | 2 |
| 3 | A randomized phaseⅡstudy to compare oxaliplatin plus 5-fluorouracil and leucovorin(FOLFOX4)versus oxaliplatin plus raltitrexed(TOMOX)as first-line chemotherapy for advanced colorectal cancer显示文摘 | GRAVALOS C SALUT A GARCA-GIRN C | 2012 | Clin Transl Oncol2012，14，8： | 1 |
| 4 | Adjuvant chemotherapy for stages Ⅱ , Ⅲ and IV of colon cancer 显示文摘 | Gravalos C Garcia-Escobar I Garcia-Alfonso P | 2009 | Clin Transl Onco12009，11，8： | 1 |
| 5 | Polyaromatic alkaloids from marine intertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by Pglycoprotein显示文摘 | Gravalos MDG | 1996 | Br J Cancer1996，74，： | 1 |
| 6 | HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target 显示文摘 | Gravalos C Jimeno A | 2008 | Ann Oncol2008，19，9： | 1 |
| 7 | HER2/neu in gastric cancer a new prognostic factor and a novel therapeutic target显示文摘 | Gravalos C Jimeno A | 2008 | Ann Oncol2008，19，9： | 1 |
| 8 | HER2in gastric cancer:a new prognostic factor and a novel therapeutic target显示文摘 | Gravalos C Jimeno A | 2008 | Ann Oncol2008，19，9： | 1 |
| 9 | Halitulin, a new cytotoxic alkaloid from the marine sponge Haliclona tulearensis 显示文摘 | KASHMAN Y KOREN-GOLDSHLAGER G GRAVALOS M D G | 1999 | Tetrahedron Lett1999，40，： | 1 |
| 10 | Phase Ⅱ study of trastuzumab and cisplatin as first-line therapy in patients with HER2-positive advanced gastric or gastro-esophageal junction cancer 显示文摘 | Gravalos C Gomez-Martin C Rivera F | 2011 | Clin Transl Oncol2011，113，3： | 1 |
| 11 | HER2 in Gastric Cancer: a New Prognostic Factor and a Novel Therapeutic Target 显示文摘 | Gravalos C Jimeno A | 2008 | Ann Oncol2008，19，： | 1 |
| 12 | HER2 in gastric cancer:a new prognostic factor and a novel therapeutic target显示文摘 | Gravalos C Jimeno A | 2008 | Ann Oncol2008，19，9： | 1 |
| 13 | HELL2 in gastric cancer: a new prog- nostic factor and a novel therapeutic target显示文摘 | Gravalos C Jimeno A | 2008 | Ann Oncol2008，19，9： | 1 |
| 14 | Her-2 in gastric cancer:a new prognositic factor and a novel therapeutic target显示文摘 | Gravalos C Jimeno A | | 0，，09： | 1 |
| 15 | HER-2 in gastric cancer:a new prognostic factor and a novel therapeutic target显示文摘 | Gravalos C Jimeno A | 2008 | Ann of Oncol2008，19，19： | 1 |
| 16 | In situ eompatibilization of polyurethane with poly (ethylene terephthalate) 显示文摘 | SAMIOS C K GRAVALOS K G KALFOGLOU N K | 2000 | European Polymer Journal2000，，36： | 1 |
| 17 | HER2 in gastric cancer:a new prognostic factor and a nover therapeutic target显示文摘 | Gravalos C Jimeno A | 2008 | Ann Oncol2008，19，9： | 1 |
| 18 | Adjuvantchemotherapy for stages H,ID and IV of colon cancer显示文摘 | Gravalos C Garcia-Escobar I Garcia-Alfonso P | 2009 | ClinTransl Oncol2009，11，8： | 1 |
| 19 | HER2 in gastric cancer:a new prognostic factorand a novel therapeutic target显示文摘 | Gravalos C Jimeno A | 2008 | Ann Oncol2008，19，： | 1 |
| 20 | Integration of panitumumab into the treatment of colorectal cancer显示文摘 | Cristina Gravalos Javier Cassinello Pilar García-Alfonso Antonio Jimeno | 2009 | Critical Reviews in Oncology and Hematology2009，，1： | 1 |
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