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| 1 | Osteoporosis and obesity: Role of Wnt pathway in human and murine models显示文摘Studies concerning the pathophysiological connection between obesity and osteoporosis are currently an intriguing area of research.Although the onset of these two diseases can occur in a different way,recent studies have shown that obesity and osteoporosis share common genetic and environmental factors.Despite being a risk factor for health,obesity has traditionally been considered positive to bone because of beneficial effect of mechanical loading,exerted by high body mass,on bone formation.However,contrasting studies have not achieved a clear consensus,suggesting instead that excessive fat mass derived from obesity condition may not protect against osteoporosis or,even worse,could be rather detrimental to bone.On the other hand,it is hitherto better established that,since adipocytes and osteoblasts are derived from a common mesenchymal stem cell precursor,molecules that lead to osteoblastogenesis inhibit adipogenesis and vice versa.Here we will discuss the role of the key molecules regulating adipocytes and osteoblasts differentiation,which are peroxisome proliferators activated receptor-γand Wnts,respectively.In particular,wewill focus on the role of both canonical and non-canonical Wnt signalling,involved in mesenchymal cell fate regulation.Moreover,at present there are no experimental data that relate any influence of the Wnt inhibitor Sclerostin to adipogenesis,although it is well known its role on bone metabolism.In addition,the most common pathological condition in which there is a simultaneous increase of adiposity and decrease of bone mass is menopause.Given that postmenopausal women have high Sclerostin level inversely associated with circulating estradiol level and since the sex hormone replacement therapy has proved to be effective in attenuating bone loss and reversing menopause-related obesity,we hypothesize that Sclerostin contribution in adipogenesis could be an active focus of research in the coming years. | Graziana Colaianni Giacomina Brunetti Maria Felicia Faienza Silvia Colucci Maria Grano | 2014 | World Journal of Orthopedics2014，5，3： | 19 |
| 2 | Mechanisms of altered bone remodeling in children with type 1 diabetes显示文摘Bone loss associated with type 1 diabetes mellitus(T1DM)begins at the onset of the disease,already in childhood,determining a lower bone mass peak and hence a greater risk of osteoporosis and fractures later in life.The mechanisms underlying diabetic bone fragility are not yet completely understood.Hyperglycemia and insulin deficiency can affect the bone cells functions,as well as the bone marrow fat,thus impairing the bone strength,geometry,and microarchitecture.Several factors,like insulin and growth hormone/insulin-like growth factor 1,can control bone marrow mesenchymal stem cell commitment,and the receptor activator of nuclear factor-κB ligand/osteoprotegerin and Wnt-b catenin pathways can impair bone turnover.Some myokines may have a key role in regulating metabolic control and improving bone mass in T1DM subjects.The aim of this review is to provide an overview of the current knowledge of the mechanisms underlying altered bone remodeling in children affected by T1DM. | Giacomina Brunetti Gabriele D'Amato Stefania De Santis Maria Grano Maria Felicia Faienza | 2021 | World Journal of Diabetes2021，12，7： | 3 |
| 3 | Control of grinding conditions in the flotation of galena and its separation from pyrite显示文摘 | Y Peng S Grano D Fomasiero | 2003 | International Journal of Mineral Processing2003，70，14： | 1 |
| 4 | Galvanic interaction of grinding media with pyrite and its effect on floatation显示文摘 | Huang G Grano S | 2005 | Minerals Engineering2005，18，2： | 1 |
| 5 | Control of grinding conditions in the flotation of chalcopyrite and its separation from pyrite 显示文摘 | Y Peng S Grano D Fomasiero | 2003 | International Journal Mineral Processing2003，69，14： | 1 |
| 6 | The effect of high intensity conditioning on the flotation of a nickel,part 2:mechanisms显示文摘 | Chen G Grano S Sobieraj S | 1999 | Minerals Engineering1999，12，11： | 1 |
| 7 | Localization and possible role of two different alpha v bern 3 integrin conformations in resting and resorbing osteoclasts显示文摘 | Faccio R Grano M Colucci S | 2002 | J Cell Sci2002，115，14： | 1 |
| 8 | Prepmation of atarch betainate: a novd cationic atarch derivative 显示文摘 | Grano H Yli - Kauhahxmm J Suomi T | 2000 | Carbohydrate Polymers2000，41，3： | 1 |
| 9 | Flotation behavior of fine particles with respect to contact angle显示文摘 | Chipfunhu D Zanin M Grano S | 2012 | Chemical Engineering Research and Design2012，90，1： | 1 |
| 10 | Recovery mechanisims for pentlandite and MgO-bearing gangue minerals in nickel ores from western australia 显示文摘 | PIETROBON M C GRANO S R SOBIERAJ S RALSTON J | 1997 | Minerals Engineering1997，10，8： | 1 |
| 11 | Mechanism for the recovery of silicate gangue minerals in the flotation of ultrafine sphalerite显示文摘 | DUARTE A C P GRANO S R | 2007 | Minerals Engineering2007，20，8： | 1 |
| 12 | Preparation of starch betainate: a novel cationic starch derivative 显示文摘 | Grano H Yli-Kauhaluoma J Suortti T | 2000 | Carbohydrate Polymers2000，41，3： | 1 |
| 13 | Long-term disease-specific quality of life in adult anorectal malformationpatients显示文摘 | Grano C Aminoff D Lucidi F | | 0，，04： | 1 |
| 14 | Mechanism for the recovery of silicate gangueminerals in the flotation of ultrafine sphalerite显示文摘 | Duarte A C P Grano S R | 2007 | Minerals Engineering2007，20，4： | 1 |
| 15 | Social- cognitive deter- minants of physical activity attendance in older adults显示文摘 | Lucidi F Grano C Barbaranelli C | 2006 | J Ag- ing Phys Act2006，14，3： | 1 |
| 16 | Recovery mechanisms for pentlandite and MgO-bearing gangue min- erals in nickel ores from Western Australia显示文摘 | Pietrobon MC Grano SR Sobieraj S Ralston J | 1997 | Minerals Engineering1997，10，8： | 1 |
| 17 | Neridronate and human osteoblasts in normal, osteoporotic and osteoarthritic subjects显示文摘 | Corrado A Cantatore FP Grano M | 2005 | Clin Rheumatol2005，24，5： | 1 |
| 18 | Control of grinding conditions in the flotation of galena and its separation from pyrite显示文摘 | Peng Y Grano S Fornasiero D at el | 2003 | International Journal of Mineral Processing2003，70，14： | 1 |
| 19 | Immunocy to chemical distribution of extracellular matrix receptors in human osteoclasts:a beta 3 integyin is colocalized with vonculin and talin in the podosomes of oste o clasto ma giant cells显示文摘 | Zambonin -Zallone A Teti A Grano M | 1989 | Exp Cell Res1989，182，2： | 1 |
| 20 | Neridronate and human os- teoblasts in normal, osteoporotic and osteoarthritic subjects 显示文摘 | Corrado A Cantatore FP Grano M | 2005 | Clin Rheumatol2005，24，5： | 1 |
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