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| 1 | Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis显示文摘AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative colitis.METHODS: The ADAPT study was a prospective, openlabel, multicenter study in pediatric patients with moderate, active ulcerative colitis with pediatric ulcerative colitis activity index(PUCAI) of 35-64. Patients received one weekly apheresis with Adacolumn granulocyte, monocyte/macrophage adsorptive(GMA) apheresis over 5 consecutive weeks, optionally followed by up to 3 additional apheresis treatments over 3 consecutive weeks. The primary endpoint was the change in mean PUCAI between baseline and week 12; the secondary endpoint was improvement in PUCAI categorized as(Significant Improvement, PUCAI decrease of ≥ 35), Moderate Improvement(PUCAI decrease of 20 < 35), Small Improvement(PUCAI decrease of 10 < 20) or No change(PUCAI decrease of < 10). RESULTS: Twenty-five patients(mean age 13.5 years; mean weight 47.7 kg) were enrolled. In the intention-to-treat set(ITT), the mean value for PUCAI improvement was 22.3 [95%CI: 12.9-31.6; n = 21]. In the per-protocol(PP) set, the mean improvement was 36.3 [95%CI: 31.4-41.1; n = 8]. Significant Improvement was recorded for 9 out of 20 patients(45%); 5 out of 20 patients(25%) had Moderate Improvement and one patient(5%) had No Change in PUCAI score at week 12. In the PP set, six out of eight patients(75%) showed Significant Improvement; and in two out of eight patients(25%) Moderate Improvement was recorded. The endoscopic activity index(EAI) decreased by 3 points on average. Seven(7) out of 21(33%) patients in ITT and 4 out of 8(50%) patients in PP have used steroids during the clinical investigation. The mean steroid dosage for these patients in the ITT set decreased from a mean 12.4 mg to 10 mg daily on average from Baseline to week 12.CONCLUSION: Adacolumn; GMA apheresis treatment was effective in pediatric patients with moderate active Ulcerative Colitis. No new safety signals were reported. The present data contribute to considering GMA apheresis as a therapeutic option in pediatric patients having failed first line therapy. | Tarja Ruuska Peter Küster Lena Grahnquist Fredrik Lindgren Anne Vibeke Wewer | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 2 | Increasing Incidence of Paediatric Inflammatory Bowel Disease in Northern Stockholm County, 2002–2007显示文摘 | Petter Malmborg Lena Grahnquist Johan Lindholm Scott Montgomery Hans Hildebrand | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，1： | 2 |
| 3 | Early development of human gastric H,K-adenosine triphosphatase显示文摘 | Grahnquist L Ruuska T Finkel Y | 2000 | J Pediatr Gast roenterol Nutr2000，30，5： | 1 |
| 4 | Early development of human gastric H, K-adenosine triphosphatase 显示文摘 | Grahnquist L Ruuska T Finkel Y | 2000 | J Pediatr Gastroenterol Nutr2000，30，5： | 1 |
| 5 | Changing pattern of paediatric inflammatory bowel disease in northern Stockhom 1990-2001 显示文摘 | Hildebrand H Finkel Y Grahnquist L | 2003 | Gut2003，52，： | 1 |
| 6 | Neonatal Proteus meningoet eephalitis ease report显示文摘 | GRAHNQUIST L LUNDBERG B TULLUS K | 1992 | APMIS1992，100，8： | 1 |
| 7 | Cesarean section and the risk of pediatric C rohn' s disease显示文摘 | Malmborg P Bahmanyar S Grahnquist L | 2012 | Inflamm Bowel Dis2012，18，4： | 1 |
| 8 | Cesarean section and the risk of pediatric Crohn' s disease显示文摘 | Malmborg P Bahmanyar S Grahnquist L | | 0，，04： | 1 |
| 9 | Regulation of K^+ transport in the rat distal colon via angiotensin Ⅱ subtype receptors and K^+-pathways显示文摘 | Grahnquist L Chen M Gerasev A | 2001 | Acta Physiol Scand2001，171，2： | 1 |
| 10 | Changing pattern of paediatric inflammatory bowel disease in northern Stockbom 1990-2001 显示文摘 | Hildebrand H Finkel Y Grahnquist L | 2003 | Gut2003，52，10： | 1 |
| 11 | Cesarean section and the risk of pediatrie Crohn's disease显示文摘 | Malmborg P Bahmanyar S Grahnquist L | 2012 | Inflamm Bowel Dis2012，18，4： | 1 |
| 12 | Early development of human gastric H, K-adenosine triphosphatase 显示文摘 | Grahnquist L Ruuska T Finkel Y | 2000 | Journal of Pediatric Gastroenterology and Nutrition2000，30，5： | 1 |
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