|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Experimental study of a percussive process for rock fragmentation 显示文摘 | Karlsson LG Lundberg B Sundin KG | 1989 | Int J Rock Mech Min Sci & Geom1989，26，1： | 1 |
| 3 | Relationship between vitamin use,smoking,and nausea and vomiting of pregnancy显示文摘 | Lundberg G Aberg A | 2003 | Acta obstericicia et Gynecologica scandinavica2003，82，10： | 1 |
| 4 | Tungsten Long-Rod Penetration into Confined Cylinders of Boron Carbide at and above Ordnance Velocities显示文摘 | Westerling L Lundberg P Lundberg B | 2001 | Int J Impact Eng2001，25，7： | 1 |
| 5 | Fear,pain and stress hormones during childbirth显示文摘 | Alehagen S Wijma B Lundberg U | 2005 | J Psychosom Obstet Gynaecol2005，26，： | 1 |
| 6 | Fear, pain and stress hormones during childbirth显示文摘 | Alehagen S Wijrna B Lundberg U | 2005 | J Psychosom Obstet Gynaecol2005，26，3： | 1 |
| 7 | Euler Angle Dilution of Precision in GPS Attitude Determination显示文摘 | Yoon S P Lundberg J B | 2001 | IEEE2001，37，3： | 1 |
| 8 | Transition between interface defeat andpenetration for tungsten projectiles and four silicon carbide materi-als 显示文摘 | Lundberg P Lundberg B | 2005 | International Journal of Impact Engineering2005，31，7： | 1 |
| 9 | Specific binding of sterically stabilized ant-B-cell immunoliposomes and cytotoxicity of entrapped doxorubicin显示文摘 | Lundberg B B Griffiths G Hansen H J | 2000 | Int J Pharm2000，205，12： | 1 |
| 10 | Selective tissue accumulation of manganese and its effect on regional blood flow and haemodynamics after intravenous infusion of its chloride salt in the rat 显示文摘 | Gerdin B McCann E Lundberg C | 1985 | Int J Tissue React1985，7，3： | 1 |
| 11 | Impact of conical tungstenprojectiles on flat silicon carbide targets : transition from interfacedefeat to penetration 显示文摘 | Lundberg P Renstr6m R Lundberg B | 2006 | International journal of Impact Engineer-ing2006，32，11： | 1 |
| 12 | Stressful memo- ties and psychological distress in adult mechanically ventila- ted intensive care patients-a 2-month follow-up study 显示文摘 | Samuelson K A Lundberg D Fridlund B | 2007 | Acta Anaesthesiol Scand2007，51，6： | 1 |
| 13 | Non-motorized Transport and University Populations:An Analysis of Connectivity and Network Perceptions显示文摘 | LUNDBERG B WEBER J | 2014 | Journal of Transport Geography2014，，39： | 1 |
| 14 | A Split Hopkinson Bar study of energy absorption in dynamic rock fragmentation显示文摘 | LUNDBERG B A | 1976 | Int J Rock Mech Min & Geomech Abstr1976，13，： | 1 |
| 15 | Separation of advanced from mild fibrosis in diffuse liver disease using 31 P magnetic reso-nance spectroscopy显示文摘 | Noren B Dahlqvist O Lundberg P | 2008 | Eur J Radiol2008，66，2： | 1 |
| 16 | Structural relations along the margins of the offshore Taiwan accretionary wedge:implications for accretion and crustal kinematics显示文摘 | Reed D L Lundberg N Liu C S Kuo B Y | 1992 | Acta Geologica Taiwanica1992，30，： | 1 |
| 17 | Computer modeling and simulation of percussive drilling of rock显示文摘 | Lundberg B | 1993 | Comprehensive Rock Engineering1993，，： | 1 |
| 18 | In vivo photoloxicity of nonsteroidal anti-inflammatory drugs evaluated by the mouse tail technique 显示文摘 | LJUNGGREN B LUNDBERG K | 1985 | Photodermatol1985，2，6： | 1 |
| 19 | Stressful memories and psychological distress in adult mechanically ventilated intensive care patients - a 2-month follow-up study显示文摘 | Samuelson KA Lundberg D Fridlund B | 2007 | Acta Anaesthesiol Scand2007，51，6： | 1 |
| 20 | Mitigation of Satellite Orbit Errors Resulting from the Numerical Integration Across Shadow Boundaries显示文摘 | Lundberg B | 2000 | Applied Mathematics and Computation2000，，112： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员